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SNAPIN Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS644488

May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release by potentiating the interaction of synaptotagmins with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences… More details

$880 / 0.1 mg +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
SNAPAP (SNAPIN), Monoclonal Antibody
Full Product Name
SNAPAP (SNARE-associated Protein Snapin, Biogenesis of Lysosome-related Organelles Complex 1 Subunit 7, BLOC-1 Subunit 7, Synaptosomal-associated Protein 25-binding Protein, SNAP-associated Protein, BLOC1S7, SNAP25BP, SNAPIN)
Product Gene Name
anti-SNAPIN antibody
Product Synonym Names
Anti -SNAPAP (SNARE-associated Protein Snapin, Biogenesis of Lysosome-related Organelles Complex 1 Subunit 7, BLOC-1 Subunit 7, Synaptosomal-associated Protein 25-binding Protein, SNAP-associated Protein, BLOC1S7, SNAP25BP, SNAPIN)
Immunogen Sequence
DSHVHAVRES QVELREQIDN LATELCRINE DQKVALDLDP YVKKLLNARR RVVLVNNILQ NAQERLRRLN HSVAKETARR RAMLDSGIYP PGSPGK*
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
3H1
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human SNAPAP.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
14,874 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (153631130..153634328). Location: 1q21.3
OMIM
607007
3D Structure
ModBase 3D Structure for O95295
Immunogen
Partial recombinant corresponding to aa41-137 from SNAPAP (NP_036569) with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-SNAPIN antibody

Antibodies; Abs to Neuroscience
Applications Tested/Suitable for anti-SNAPIN antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-SNAPIN antibody
Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 3ug/ml

Western Blot (WB) of anti-SNAPIN antibody

Western Blot detection against Immunogen (36.67kD).
Mouse Anti-SNAPIN Monoclonal Antibody – Cat# MBS644488

Immunohistochemistry (IHC) of anti-SNAPIN antibody

Immunoperoxidase of monoclonal antibody to SNAPIN on formalin-fixed paraffin-embedded human tonsil. [antibody concentration 3ug/ml]
Mouse Anti-SNAPIN Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS644488

Testing Data of anti-SNAPIN antibody

Detection limit for recombinant GST tagged SNAPIN is 1ng/ml as a capture antibody.
Mouse Anti-SNAPIN Monoclonal Antibody, Testing Data – Cat# MBS644488

Other Notes

Small volumes of anti-SNAPIN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SNAPIN purchase

MBS644488 is an antibody targeting SNAPIN. Also known as SNAPAP (SNARE-associated Protein Snapin, Biogenesis of Lysosome-related Organelles Complex 1 Subunit 7, BLOC-1 Subunit 7, Synaptosomal-associated Protein 25-binding Protein, SNAP-associated Protein, BLOC1S7, SNAP25BP, SNAPIN). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for SNAPIN. It may not necessarily be applicable to this product.

NCBI GI #
6912674
NCBI GeneID
23557
NCBI Accession #
NP_036569.1
UniProt Primary Accession #
O95295
UniProt Secondary Accession #
Q5SXU8; D3DV56
UniProt Related Accession #
O95295
GenBank Nucleotide #
NM_012437.5
NCBI Official Full Name
SNARE-associated protein Snapin
NCBI Official Synonym Full Names
SNAP-associated protein
NCBI Official Symbol
SNAPIN
NCBI Official Synonym Symbols
BLOS7; SNAPAP; BLOC1S7
UniProt Protein Name
SNARE-associated protein Snapin
UniProt Synonym Protein Names
Biogenesis of lysosome-related organelles complex 1 subunit 7; BLOC-1 subunit 7; Synaptosomal-associated protein 25-binding protein
Protein Family
SNARE-associated protein
UniProt Gene Name
SNAPIN
UniProt Synonym Gene Names
BLOC1S7; SNAP25BP; SNAPAP; BLOC-1 subunit 7
UniProt Entry Name
SNAPN_HUMAN
NCBI Protein Information
SNARE-associated protein Snapin; BLOC-1 subunit 7; SNAP-25-binding protein; SNARE associated protein snapin; synaptosomal-associated protein 25-binding protein; biogenesis of lysosomal organelles complex-1, subunit 7; biogenesis of lysosome-related organelles complex 1 subunit 7

NCBI Summary for SNAPIN

The protein encoded by this gene is a coiled-coil-forming protein that associates with the SNARE (soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor) complex of proteins and the BLOC-1 (biogenesis of lysosome-related organelles) complex. Biochemical studies have identified additional binding partners. As part of the SNARE complex, it is required for vesicle docking and fusion and regulates neurotransmitter release. The BLOC-1 complex is required for the biogenesis of specialized organelles such as melanosomes and platelet dense granules. Mutations in gene products that form the BLOC-1 complex have been identified in mouse strains that are models of Hermansky-Pudlak syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
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UniProt Comments for SNAPIN

SNAPIN: a component of the SNARE complex of proteins that is required for synaptic vesicle docking and fusion. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release by potentiating the interaction of synaptotagmins with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells. Phosphorylation by PKA modulates its interaction with the SNARE complex.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 1q21.3

Cellular Component: Golgi membrane; Golgi apparatus; synaptic vesicle; transport vesicle; cytoplasmic vesicle membrane; synaptic vesicle membrane; perinuclear region of cytoplasm; nucleolus; synapse; cell junction; secretory granule

Molecular Function: protein binding; SNARE binding

Biological Process: viral reproduction; synaptic vesicle maturation; neurotransmitter secretion; synaptic vesicle transport; synaptic vesicle fusion to presynaptic membrane; intracellular protein transport; synaptic vesicle exocytosis; melanosome organization and biogenesis; regulation of protein binding; anterograde synaptic vesicle transport; endosome to lysosome transport; anterograde axon cargo transport; neurite development
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Research Articles on SNAPIN

1. Our findings reveal that Atg14L, previously considered to be solely a Beclin 1-binding autophagy protein, plays a novel role in the late stage of endocytic trafficking in conjunction with Snapin

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SNAPIN antibody

 Reference Product  PubMed Publications
 SNAP25 antibody  >18 publications with SNAPIN and SNAP25
 DTNBP1 antibody  >4 publications with SNAPIN and DTNBP1
 TMEM27 antibody  >3 publications with SNAPIN and TMEM27
 MUTED antibody  >3 publications with SNAPIN and MUTED
 BLOC1S1 antibody  >3 publications with SNAPIN and BLOC1S1
 EBAG9 antibody  >2 publications with SNAPIN and EBAG9
 PLDN antibody  >2 publications with SNAPIN and PLDN
 BLOC1S3 antibody  >1 publications with SNAPIN and BLOC1S3
 BLOC1S2 antibody  >1 publications with SNAPIN and BLOC1S2

Pathways associated with anti-SNAPIN antibody

 Products by Pathway  Pathway Diagram
 Clathrin Derived Vesicle Budding Pathway antibodies  Clathrin Derived Vesicle Budding Pathway Diagram
 Golgi Associated Vesicle Biogenesis Pathway antibodies  Golgi Associated Vesicle Biogenesis Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
 Trans-Golgi Network Vesicle Budding Pathway antibodies  Trans-Golgi Network Vesicle Budding Pathway Diagram

Diseases associated with anti-SNAPIN antibody

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >5 publications with SNAPIN and Disease Models, Animal
 Nervous System Diseases Antibodies  >3 publications with SNAPIN and Nervous System Diseases
 Death Antibodies  >3 publications with SNAPIN and Death
 Neoplasms Antibodies  >2 publications with SNAPIN and Neoplasms
 Hypertrophy Antibodies  >2 publications with SNAPIN and Hypertrophy
 Heart Diseases Antibodies  >1 publications with SNAPIN and Heart Diseases
 Liver Diseases Antibodies  >1 publications with SNAPIN and Liver Diseases
 Autoimmune Diseases Antibodies  >1 publications with SNAPIN and Autoimmune Diseases
 Learning Disorders Antibodies  >1 publications with SNAPIN and Learning Disorders
 Inflammation Antibodies  >1 publications with SNAPIN and Inflammation

Organs/Tissues associated with anti-SNAPIN antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >22 publications with SNAPIN and Brain
 Kidney Antibodies  >7 publications with SNAPIN and Kidney
 Pancreas Antibodies  >6 publications with SNAPIN and Pancreas
 Muscle Antibodies  >4 publications with SNAPIN and Muscle
 Blood Antibodies  >3 publications with SNAPIN and Blood
 Liver Antibodies  >3 publications with SNAPIN and Liver
 Heart Antibodies  >3 publications with SNAPIN and Heart
 Uncharacterized Tissue Antibodies  >2 publications with SNAPIN and Uncharacterized Tissue
 Testis Antibodies  >1 publications with SNAPIN and Testis
 Prostate Antibodies  >1 publications with SNAPIN and Prostate
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