Mouse Anti-FGD5 Polyclonal Antibody – Cat# MBS644517

Western Blot analysis of FGD5 expression in transfected 293T cell line by FGD5 polyclonal antibody. Lane 1: FGD5 transfected lysate (59.4kD). Lane 2: Non-transfected lysate.

FGD5 Antibody – Mouse Polyclonal

Name: FGD5 Antibody; Polyclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS644517
Price: 880 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS644517

Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation,… More details

$880 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

FGD5, Polyclonal Antibody

Full Product Name

FGD5 (FYVE, RhoGEF And PH Domain-containing Protein 5, Zinc Finger FYVE Domain-containing Protein 23, ZFYVE23, FLJ00274, FLJ39957)

Product Gene Name

anti-FGD5 antibody

Product Synonym Names

Anti -FGD5 (FYVE, RhoGEF And PH Domain-containing Protein 5, Zinc Finger FYVE Domain-containing Protein 23, ZFYVE23, FLJ00274, FLJ39957)

Immunogen Sequence

MRALDDMDHE GRDTLAREEL RQGLSELPAI HDLHQGILEE LEERLSNWES QQKVADVFLA REQGFDHHAT HILQFDRYLG LLSENCLHSP RLAAAVREFE QSVQGGSQTA KHRLLRVVQR LFQYQVLLTD YLNNLCPDSA EYDNTQGALS LISKVTDRAN DSMEQGENLQ KLVHIEHSVR GQGDLLQPGR EFLKEGTLMK VTGKNRRPRH LFLMNDVLLY TYPQKDGKYR LKNTLAVANM KVSRPVMEKV PYALKIETSE SCLMLSASSC AERDEWYGCL SRALPEDYKA QALAAFHHSV EIRERLGVSL GERPPTLVPV THVMMCMNCG CDFSLTLRRH HCHACGKIVC RNCSRNKYPL KYLKDRMAKV CDGCFGELKK RGRAVPGLMR ERPVSMSFPL SSPRFSGSAF SSVFQSINPS TFKKQKKVPS ALTEVAASGE GSAISGYLSR CKRGKRHWKK LWFVIKGKVL YTYMASEDKV ALESMPLLGF TIAPEKEEGS SEVGPIFHLY HKKTLFYSFK AEDTNSAQRW IEAMEDASVL

Clonality

Polyclonal

Isotype

IgG

Host

Mouse

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Recognizes human FGD5.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

159,891 Da

Chromosome Location

Chromosome: 3; NC_000003.11 (14852247..14976072). Location: 3p25.1

OMIM

614788

3D Structure

ModBase 3D Structure for Q6ZNL6

Immunogen

Full length human FGD5, aa1-540 (AAH35364.1).

Product Categories/Family for anti-FGD5 antibody

Antibodies; Abs to G Proteins

Applications Tested/Suitable for anti-FGD5 antibody

Western Blot (WB)

Application Notes for anti-FGD5 antibody

Suitable for use in Western Blot.

Other Notes

Small volumes of anti-FGD5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FGD5 purchase

MBS644517 is an antibody targeting FGD5. Also known as FGD5 (FYVE, RhoGEF And PH Domain-containing Protein 5, Zinc Finger FYVE Domain-containing Protein 23, ZFYVE23, FLJ00274, FLJ39957). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for FGD5. It may not necessarily be applicable to this product.

NCBI GI #

194018497

NCBI GeneID

152273

NCBI Accession #

NP_689749.3

UniProt Primary Accession #

Q6ZNL6

UniProt Secondary Accession #

Q6MZY1; Q7Z303; Q8IYP3; Q8N861; Q8N8G4; B3KVQ3

UniProt Related Accession #

Q6ZNL6

GenBank Nucleotide #

NM_152536.3

NCBI Official Full Name

FYVE, RhoGEF and PH domain-containing protein 5

NCBI Official Synonym Full Names

FYVE, RhoGEF and PH domain containing 5

NCBI Official Symbol

FGD5

NCBI Official Synonym Symbols

ZFYVE23

UniProt Protein Name

FYVE, RhoGEF and PH domain-containing protein 5

UniProt Synonym Protein Names

Zinc finger FYVE domain-containing protein 23

Protein Family

FYVE, RhoGEF and PH domain-containing protein

UniProt Gene Name

FGD5

UniProt Synonym Gene Names

ZFYVE23

UniProt Entry Name

FGD5_HUMAN

NCBI Protein Information

FYVE, RhoGEF and PH domain-containing protein 5; zinc finger FYVE domain-containing protein 23

UniProt Comments for FGD5

FGD5: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs, Rac/Rho; GEFs

Chromosomal Location of Human Ortholog: 3p25.1

Cellular Component: ruffle; Golgi apparatus; cytoskeleton; lamellipodium; endoplasmic reticulum; early endosome; cytoplasm

Molecular Function: small GTPase binding; protein binding; Rho guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity; metal ion binding

Biological Process: regulation of cell shape; filopodium formation; cytoskeleton organization and biogenesis; actin cytoskeleton organization and biogenesis; positive regulation of GTPase activity

Research Articles on FGD5

1. FGD5 regulates endothelial adhesion, survival, and angiogenesis by modulating phosphatidylinositol 3-kinase signaling.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FGD5 antibody

Reference Product	PubMed Publications
LRRC3B antibody	>2 publications with FGD5 and LRRC3B

Diseases associated with anti-FGD5 antibody

Disease Name	Pubmed Publications
Lung Diseases Antibodies	>1 publications with FGD5 and Lung Diseases
Neoplasms Antibodies	>1 publications with FGD5 and Neoplasms
Eye Diseases Antibodies	>1 publications with FGD5 and Eye Diseases
Necrosis Antibodies	>1 publications with FGD5 and Necrosis
Inflammation Antibodies	>1 publications with FGD5 and Inflammation

Organs/Tissues associated with anti-FGD5 antibody

Organ/Tissue Name	Pubmed Publications
Vascular Antibodies	>4 publications with FGD5 and Vascular
Eye Antibodies	>1 publications with FGD5 and Eye
Lung Antibodies	>1 publications with FGD5 and Lung
Muscle Antibodies	>1 publications with FGD5 and Muscle