Rabbit Anti-CDKL5 Polyclonal Antibody – Cat# MBS644540

Mouse Cdkl5 Antibody (C-term) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the Cdkl5 antibody detected the Cdkl5 protein (arrow).

CDKL5 Antibody – Rabbit Polyclonal

Name: CDKL5 Antibody; Polyclonal; Rabbit; Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS644540
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS644540

MBS644540 is an antibody targeting CDKL5. Also known as Cdkl5, CT (Cdkl5, Cyclin-dependent kinase-like 5). Reactive in Mouse. Host: Rabbit. Cdkl5 mediates phosphorylation of MECP2 (By similarity). More details

$895 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Cdkl5, Polyclonal Antibody

Full Product Name

Cdkl5, CT (Cdkl5, Cyclin-dependent kinase-like 5)

Product Gene Name

anti-CDKL5 antibody

Product Synonym Names

Anti -Cdkl5, CT (Cdkl5, Cyclin-dependent kinase-like 5)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Mouse

Form/Format

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Mouse

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

115,538 Da

Chromosome Location

Chromosome: X; NC_000023.10 (18443725..18671749). Location: Xp22

OMIM

300203

3D Structure

ModBase 3D Structure for O76039

Immunogen

Mouse Cdkl5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 729-758 amino acids from the C-terminal region of human Mouse Cdkl5.

Product Categories/Family for anti-CDKL5 antibody

Antibodies; Abs to Protein Kinases

Applications Tested/Suitable for anti-CDKL5 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-CDKL5 antibody

Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Other Notes

Small volumes of anti-CDKL5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CDKL5. It may not necessarily be applicable to this product.

NCBI GI #

83367069

NCBI GeneID

6792

NCBI Accession #

NP_001032420.1

UniProt Primary Accession #

O76039

UniProt Secondary Accession #

Q14198; Q5H985; Q8IYC7; Q9UJL6; G9B9X4

UniProt Related Accession #

O76039

GenBank Nucleotide #

NM_001037343.1

NCBI Official Full Name

cyclin-dependent kinase-like 5

NCBI Official Synonym Full Names

cyclin-dependent kinase-like 5

NCBI Official Symbol

CDKL5

NCBI Official Synonym Symbols

ISSX; STK9; EIEE2

UniProt Protein Name

Cyclin-dependent kinase-like 5

UniProt Synonym Protein Names

Serine/threonine-protein kinase 9

Protein Family

Cyclin-dependent kinase

UniProt Gene Name

CDKL5

UniProt Synonym Gene Names

STK9

UniProt Entry Name

CDKL5_HUMAN

NCBI Protein Information

cyclin-dependent kinase-like 5; serine/threonine kinase 9; serine/threonine-protein kinase 9; cyclin dependent kinase 5 transcript

NCBI Summary for CDKL5

This gene is a member of Ser/Thr protein kinase family and encodes a phosphorylated protein with protein kinase activity. Mutations in this gene have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

UniProt Comments for CDKL5

CDKL5: a protein kinase of the CDKL family. Mutations have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). Alternate transcriptional splice variants have been characterized.

Protein type: Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); Cell cycle regulation; Kinase, protein; EC 2.7.11.22; CMGC group; CDKL family

Chromosomal Location of Human Ortholog: Xp22

Cellular Component: dendrite cytoplasm; nucleoplasm; cytoplasm; nucleus

Molecular Function: protein serine/threonine kinase activity; cyclin-dependent protein kinase activity; Rac GTPase binding; kinase activity; ATP binding; protein kinase activity

Biological Process: regulation of cell cycle; positive regulation of axon extension; protein amino acid autophosphorylation; regulation of dendrite development; neuron migration; positive regulation of dendrite morphogenesis; protein amino acid phosphorylation

Disease: Angelman Syndrome; Epileptic Encephalopathy, Early Infantile, 2

Research Articles on CDKL5

1. 3 known & 3 new (V966Im A1911V, H589H)mutations in the C-terminal domain of CDKL5 were found in Indian patients with Rett syndrome negative for MECP2.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CDKL5 antibody

Reference Product	PubMed Publications
MECP2 antibody	>64 publications with CDKL5 and MECP2
NTNG1 antibody	>3 publications with CDKL5 and NTNG1
NHS antibody	>3 publications with CDKL5 and NHS
PPEF1 antibody	>1 publications with CDKL5 and PPEF1
SCML2 antibody	>1 publications with CDKL5 and SCML2

Pathways associated with anti-CDKL5 antibody

Products by Pathway	Pathway Diagram
BDNF Signaling Pathway antibodies	BDNF Signaling Pathway Diagram

Diseases associated with anti-CDKL5 antibody

Disease Name	Pubmed Publications
Rett Syndrome Antibodies	>97 publications with CDKL5 and Rett Syndrome
Seizures Antibodies	>75 publications with CDKL5 and Seizures
Congenital Abnormalities Antibodies	>11 publications with CDKL5 and Congenital Abnormalities
Angelman Syndrome Antibodies	>6 publications with CDKL5 and Angelman Syndrome
Heart Diseases Antibodies	>3 publications with CDKL5 and Heart Diseases
Lung Diseases Antibodies	>1 publications with CDKL5 and Lung Diseases
Epileptic Encephalopathy, Early Infantile, 2 Antibodies	>1 publications with CDKL5 and Epileptic Encephalopathy, Early Infantile, 2

Organs/Tissues associated with anti-CDKL5 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>51 publications with CDKL5 and Brain
Eye Antibodies	>6 publications with CDKL5 and Eye
Muscle Antibodies	>5 publications with CDKL5 and Muscle
Blood Antibodies	>5 publications with CDKL5 and Blood
Testis Antibodies	>4 publications with CDKL5 and Testis
Mouth Antibodies	>3 publications with CDKL5 and Mouth
Lung Antibodies	>1 publications with CDKL5 and Lung