Rabbit Anti-PITRM1 Polyclonal Antibody – Cat# MBS644599

PITRM1 Antibody (Center) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the PITRM1 antibody detected the PITRM1 protein (arrow).

PITRM1 Antibody – Rabbit Polyclonal

Name: PITRM1 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS644599
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS644599

ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Able to degrade amyloid beta A4 (APP) protein when it accumulates… More details

$895 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PITRM1, Polyclonal Antibody

Full Product Name

PITRM1, ID (PITRM1, KIAA1104, MP1, Presequence protease, mitochondrial, Pitrilysin metalloproteinase 1)

Product Gene Name

anti-PITRM1 antibody

Product Synonym Names

Anti -PITRM1, ID (PITRM1, KIAA1104, MP1, Presequence protease, mitochondrial, Pitrilysin metalloproteinase 1)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Human

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

117,413 Da

Chromosome Location

Chromosome: 10; NC_000010.10 (3179919..3215033, complement). Location: 10p15.2

3D Structure

ModBase 3D Structure for Q5JRX3

Immunogen

PITRM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 497-526 amino acids from the Central region of human PITRM1.

Product Categories/Family for anti-PITRM1 antibody

Antibodies; Abs to Mitochondrial Proteins

Applications Tested/Suitable for anti-PITRM1 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-PITRM1 antibody

Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Other Notes

Small volumes of anti-PITRM1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PITRM1 purchase

MBS644599 is an antibody targeting PITRM1. Also known as PITRM1, ID (PITRM1, KIAA1104, MP1, Presequence protease, mitochondrial, Pitrilysin metalloproteinase 1). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PITRM1. It may not necessarily be applicable to this product.

NCBI GI #

334085252

NCBI GeneID

10531

NCBI Accession #

NP_001229238.1

UniProt Primary Accession #

Q5JRX3

UniProt Secondary Accession #

O95204; Q2M2G6; Q4VBR1; Q5JRW7; Q7L5Z7; Q9BSI6; Q9BVJ5; Q9UPP8; B3KMJ6; B4E0J8; E7ES23

UniProt Related Accession #

Q5JRX3

GenBank Nucleotide #

NM_001242309.1

NCBI Official Full Name

presequence protease, mitochondrial isoform 3

NCBI Official Synonym Full Names

pitrilysin metallopeptidase 1

NCBI Official Symbol

PITRM1

NCBI Official Synonym Symbols

MP1; PreP

UniProt Protein Name

Presequence protease, mitochondrial

UniProt Synonym Protein Names

Pitrilysin metalloproteinase 1

UniProt Gene Name

PITRM1

UniProt Synonym Gene Names

KIAA1104; MP1; hPreP; Metalloprotease 1; hMP1

UniProt Entry Name

PREP_HUMAN

NCBI Protein Information

presequence protease, mitochondrial; PreP peptidasome; pitrilysin metalloproteinase 1; metalloprotease 1 (pitrilysin family)

UniProt Comments for PITRM1

PITRM1: ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference. Belongs to the peptidase M16 family. PreP subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.24.-; Activator; Mitochondrial; Protease

Chromosomal Location of Human Ortholog: 10p15.2

Cellular Component: mitochondrion; mitochondrial matrix

Molecular Function: metal ion binding; metalloendopeptidase activity; enzyme activator activity

Biological Process: positive regulation of catalytic activity; proteolysis

Research Articles on PITRM1

1. Data show that the hPreP presequence only targets GFP to the matrix of mammalian and yeast mitochondria.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-PITRM1 antibody

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>1 publications with PITRM1 and Cardiovascular Diseases
Kidney Diseases Antibodies	>1 publications with PITRM1 and Kidney Diseases
Disease Models, Animal Antibodies	>1 publications with PITRM1 and Disease Models, Animal

Organs/Tissues associated with anti-PITRM1 antibody

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>2 publications with PITRM1 and Muscle
Liver Antibodies	>2 publications with PITRM1 and Liver
Placenta Antibodies	>2 publications with PITRM1 and Placenta
Lung Antibodies	>2 publications with PITRM1 and Lung
Brain Antibodies	>2 publications with PITRM1 and Brain
Pancreas Antibodies	>1 publications with PITRM1 and Pancreas
Heart Antibodies	>1 publications with PITRM1 and Heart
Embryonic Tissue Antibodies	>1 publications with PITRM1 and Embryonic Tissue
Kidney Antibodies	>1 publications with PITRM1 and Kidney