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Connexin 50 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS644692

GJA8 is a an integral membrane protein that belongs to the connexin family, alpha-type (group II) subfamily. One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse… More details

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Product Overview

Online Datasheet in PDF
Product Name
Connexin 50, Polyclonal Antibody
Full Product Name
Connexin 50, CT (Gap Junction alpha-8 Protein, GJA8, Connexin-50, Cx50, Lens Fiber Protein MP70)
Product Synonym Names
Anti -Connexin 50, CT (Gap Junction alpha-8 Protein, GJA8, Connexin-50, Cx50, Lens Fiber Protein MP70)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human GJA8. Species Crossreactivity: mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide selected from the C-terminal region of human GJA8 (KLH).

Product Categories/Family for anti-Connexin 50 antibody

Antibodies; Abs to Connexin; Junction Proteins
Applications Tested/Suitable for anti-Connexin 50 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-Connexin 50 antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100

Western Blot (WB) of anti-Connexin 50 antibody

Western blot analysis of mouse kidney tissue lysates (35ug/lane) using MBS644692. GJA8 (arrow) was detected using MBS644692.
Rabbit Anti-Connexin 50 Polyclonal Antibody – Cat# MBS644692

Immunohistochemistry (IHC) of anti-Connexin 50 antibody

Immunohistochemistry analysis in formalin-fixed and paraffin-embedded human cancer tissue using MBS644692, followed by secondary antibody DAB staining. This data demonstrates the use of MBS644692 for immunohistochemistry.
Rabbit Anti-Connexin 50 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS644692

Other Notes

Small volumes of anti-Connexin 50 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Connexin 50 purchase

MBS644692 is an antibody targeting Connexin 50. Also known as Connexin 50, CT (Gap Junction alpha-8 Protein, GJA8, Connexin-50, Cx50, Lens Fiber Protein MP70). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Connexin 50. It may not necessarily be applicable to this product.

NCBI GI #
151413345
NCBI Accession #
ABS11172.1
NCBI Official Full Name
connexin 50

NCBI Summary for Connexin 50

This gene encodes a transmembrane connexin protein that is necessary for lens growth and maturation of lens fiber cells. The encoded protein is a component of gap junction channels and functions in a calcium and pH-dependent manner. Mutations in this gene have been associated with zonular pulverulent cataracts, nuclear progressive cataracts, and cataract-microcornea syndrome. [provided by RefSeq, Dec 2009]
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UniProt Comments for Connexin 50

GJA8: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. A connexon is composed of a hexamer of connexins. This particular connexin only forms junctional channels. Eye lens. Belongs to the connexin family. Alpha-type (group II) subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, misc.

Chromosomal Location of Human Ortholog: 1q21.1

Cellular Component: connexon complex; integral to plasma membrane

Molecular Function: channel activity; gap junction channel activity

Biological Process: lens development in camera-type eye; cell-cell signaling; visual perception; transport; transmembrane transport; protein homooligomerization

Disease: Cataract 1, Multiple Types
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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