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SECISBP2 Antibody – Mouse Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS644789

MBS644789 is an antibody targeting SECISBP2. Also known as SECISBP2 (Selenocysteine Insertion Sequence-binding Protein 2, SECIS-binding Protein 2, SBP2). Reactive in Human. Host: Mouse. More details

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Product Overview

Online Datasheet in PDF
Product Name
SECISBP2, Polyclonal Antibody
Full Product Name
SECISBP2 (Selenocysteine Insertion Sequence-binding Protein 2, SECIS-binding Protein 2, SBP2)
Product Gene Name
anti-SECISBP2 antibody
Product Synonym Names
Anti -SECISBP2 (Selenocysteine Insertion Sequence-binding Protein 2, SECIS-binding Protein 2, SBP2)
Immunogen Sequence
MASEGPREPE SEGIKLSADV KPFVPRFAGL NVAWLESSEA CVFPSSAATY YPFVQEPPVT EQKIYTEDMA FGASTFPPQY LSSEITLHPY AYSPYTLDST QNVYSVPGSQ YLYNQPSCYR GFQTVKHRNE NTCPLPQEMK ALFKKKTYDE KKTYDQQKFD SERADGTISS EIKSARGSHH LSIYAENSLK SDGYHKRTDR KSRIIAKNVS TSKPEFEFTT LDFPELQGAE NNMSEIQKQP KWGPVHSVST DISLLREVVK PAAVLSKGEI VVKNNPNESV TANAATNSPS CTRELSWTPM GYVVRQTLST ELSAAPKNVT SMINLKTIAS SADPKNVSIP SSEALSSDPS YNKEKHIIHP TQKSKASQGS DLEQNEASRK NKKKKEKSTS KYEVLTVQEP PRIEDAEEFP NLAVASERRD RIETPKFQSK QQPQDNFKNN VKKSQLPVQL DLGGMLTALE KKQHSQHAKQ SSKPVVVSVG AVPVLSKECA SGERGRRMSQ MKTPHNPLDS SAPLMKKGKQ REIPKAKKPT SLKKIILKER QERKQRLQEN AVGPAFTSDD TQDGESGGDD QFPEQAELSG PEGMDELIST PSVEDKSEEP PGTELQRDTE ASHLAPNHTT FPKIHSRRFR DYCSQMLSKE VDACVTDLLK ELVRFQDRMY QKDPVKAKTK RRLVLGLREV LKHLKLKKLK CVIISPNCEK IQSKGGLDDT LHTIIDYACE QNIPFVFALN RKALGRSLNK AVPVSVVGIF SYDGAQDQFH KMVELTVAAR QAYKTMLENV QQELVGEPRP QAPPSLPTQG PSCPAEDGPP ALKEKEEPHY IEIWKKHLEA YSGCTLELEE SLEASTSQMM NLNL
Clonality
Polyclonal
Isotype
IgG
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human SECISBP2.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
95,462 Da
Chromosome Location
Chromosome: 9; NC_000009.11 (91933394..91974561). Location: 9q22.2
OMIM
607693
3D Structure
ModBase 3D Structure for Q96T21
Immunogen
Full length human SECISBP2, aa1-854 (AAH36109.1).

Product Categories/Family for anti-SECISBP2 antibody

Antibodies; Abs to Binding Proteins
Applications Tested/Suitable for anti-SECISBP2 antibody
Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-SECISBP2 antibody
Suitable for use in Immunofluorescence and Western Blot.
Dilution: Immunofluorescence: 10ug/ml

Western Blot (WB) of anti-SECISBP2 antibody

Western Blot analysis of SECISBP2 expression in transfected 293T cell line by SECISBP2 polyclonal antibody. Lane 1: SECISBP2 transfected lysate (93.94kD). Lane 2: Non-transfected lysate.
Mouse Anti-SECISBP2 Polyclonal Antibody – Cat# MBS644789

Immunofluorescence (IF) of anti-SECISBP2 antibody

Immunofluorescence of purified antibody to SECISBP2 on HeLa cell. [antibody concentration 10ug/ml].
Mouse Anti-SECISBP2 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS644789

Other Notes

Small volumes of anti-SECISBP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SECISBP2. It may not necessarily be applicable to this product.

NCBI GI #
83779010
NCBI GeneID
79048
NCBI Accession #
NP_076982.3
UniProt Primary Accession #
Q96T21
UniProt Secondary Accession #
Q5HYY1; Q8IYC0; Q9H0A1
UniProt Related Accession #
Q96T21
GenBank Nucleotide #
NM_024077.4
NCBI Official Full Name
selenocysteine insertion sequence-binding protein 2 isoform 1
NCBI Official Synonym Full Names
SECIS binding protein 2
NCBI Official Symbol
SECISBP2
NCBI Official Synonym Symbols
SBP2
UniProt Protein Name
Selenocysteine insertion sequence-binding protein 2
Protein Family
Selenocysteine insertion sequence-binding protein
UniProt Gene Name
SECISBP2
UniProt Synonym Gene Names
SBP2; SECIS-binding protein 2
UniProt Entry Name
SEBP2_HUMAN
NCBI Protein Information
selenocysteine insertion sequence-binding protein 2

NCBI Summary for SECISBP2

The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. The gene described in this record encodes a nuclear protein that functions as a SECIS binding protein. Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
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UniProt Comments for SECISBP2

SECISBP2: Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB. Defects in SECISBP2 are a cause of abnormal thyroid hormone metabolism (ATHYHM). This phenotype is associated with a reduction in type II iodothyronine deiodinase activity. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Translation

Chromosomal Location of Human Ortholog: 9q22.2

Cellular Component: nucleoplasm; mitochondrion; ribonucleoprotein complex

Molecular Function: ribonucleoprotein binding; mRNA 3'-UTR binding

Biological Process: selenocysteine incorporation

Disease: Thyroid Hormone Metabolism, Abnormal
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Research Articles on SECISBP2

1. The patient showed typical symptoms of SBP2 deficiency, and novel compound heterozygous mutations were identified in SBP2 (p.M515fsX563/p.Q79X).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SECISBP2 antibody

 Reference Product  PubMed Publications
 EEFSEC antibody  >6 publications with SECISBP2 and EEFSEC
 GPX1 antibody  >4 publications with SECISBP2 and GPX1
 SEPN1 antibody  >2 publications with SECISBP2 and SEPN1
 SELK antibody  >1 publications with SECISBP2 and SELK
 DIO2 antibody  >1 publications with SECISBP2 and DIO2

Diseases associated with anti-SECISBP2 antibody

 Disease Name  Pubmed Publications
 Thyroid Hormone Metabolism, Abnormal Antibodies  >8 publications with SECISBP2 and Thyroid Hormone Metabolism, Abnormal
 Nervous System Diseases Antibodies  >2 publications with SECISBP2 and Nervous System Diseases
 Liver Neoplasms Antibodies  >1 publications with SECISBP2 and Liver Neoplasms
 Disease Models, Animal Antibodies  >1 publications with SECISBP2 and Disease Models, Animal
 Liver Neoplasms, Experimental Antibodies  >1 publications with SECISBP2 and Liver Neoplasms, Experimental
 Hearing Loss, Sensorineural Antibodies  >1 publications with SECISBP2 and Hearing Loss, Sensorineural
 Inflammation Antibodies  >1 publications with SECISBP2 and Inflammation
 Growth Disorders Antibodies  >1 publications with SECISBP2 and Growth Disorders

Organs/Tissues associated with anti-SECISBP2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >9 publications with SECISBP2 and Blood
 Testis Antibodies  >4 publications with SECISBP2 and Testis
 Brain Antibodies  >1 publications with SECISBP2 and Brain
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