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SH2B1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS644802

MBS644802 is an antibody targeting SH2B1. Also known as SH2B1 (SH2B Adapter Protein 1, SH2B, KIAA1299, Pro-rich, PH and SH2 Domain-containing Signaling Mediator, PSM, SH2 Domain-containing Protein 1B). Reactive in Human. Host: Rabbit. More details

$970 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SH2B1, Polyclonal Antibody
Full Product Name
SH2B1 (SH2B Adapter Protein 1, SH2B, KIAA1299, Pro-rich, PH and SH2 Domain-containing Signaling Mediator, PSM, SH2 Domain-containing Protein 1B)
Product Gene Name
Product Synonym Names
Anti -SH2B1 (SH2B Adapter Protein 1, SH2B, KIAA1299, Pro-rich, PH and SH2 Domain-containing Signaling Mediator, PSM, SH2 Domain-containing Protein 1B)
Immunogen Sequence
MVQREELLSF MGAEEAAPDP AGVGRGGGVA GPPSGGGGQP QWQKCRLLLR SEGEGGGGSR LEFFVPPKAS RPRLSIPCSS ITDVRTTTAL EMPDRENTFV VKVEGPSEYI METVDAQHVK AWVSDIQECL SPGPCPATSP RPMTLPLAPG TSFLTRENTD SLELSCLNHS ESLPSQDLLL GPSESNDRLS QGAYGGLSDR PSASISPSSA SIAASHFDSM ELLPPELPPR IPIEEGPPAG TVHPLSAPYP PLDTPETATG SFLFQGEPEG GEGDQPLSGY PWFHGMLSRL KAAQLALTGG TGSHGVFLVR QSETRRGEYV LTFNFQGKAK HLRLSLNEEG QCRVQHLWFQ SIFDMLEHFR VHPIPLESGG SSDVVLVSYV PSSQRQQGRE QAGSHAGVCE GDGCHPDASC TLMPFGASDC VTDHLP
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human SH2B1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
79,366 Da
Chromosome Location
Chromosome: 16; NC_000016.9 (28872939..28885534). Location: 16p11.2
OMIM
608937
3D Structure
ModBase 3D Structure for Q9NRF2
Immunogen
Full length human SH2B1, aa1-426 (AAH10704.1).
Applications Tested/Suitable for anti-SH2B1 antibody
Western Blot (WB)
Application Notes for anti-SH2B1 antibody
Suitable for use in Western Blot.

Western Blot (WB) of anti-SH2B1 antibody

Western Blot analysis of SH2B1 expression in transfected 293T cell line by SH2B1 polyclonal antibody. Lane 1: SH2B1 transfected lysate (45.4kD). Lane 2: Non-transfected lysate.
Rabbit Anti-SH2B1 Polyclonal Antibody – Cat# MBS644802

Other Notes

Small volumes of anti-SH2B1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SH2B1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
SH2B adapter protein 1 isoform 3
NCBI Official Synonym Full Names
SH2B adaptor protein 1
NCBI Official Symbol
SH2B1
NCBI Official Synonym Symbols
PSM; SH2B
UniProt Protein Name
SH2B adapter protein 1
UniProt Synonym Protein Names
Pro-rich, PH and SH2 domain-containing signaling mediator; PSM; SH2 domain-containing protein 1B
Protein Family
UniProt Gene Name
SH2B1
UniProt Synonym Gene Names
KIAA1299; SH2B; PSM
UniProt Entry Name
SH2B1_HUMAN
NCBI Protein Information
SH2B adapter protein 1; SH2-B signaling protein; SH2 domain-containing protein 1B; SH2 domain-containing putative adapter SH2-B; pro-rich, PH and SH2 domain-containing signaling mediator

NCBI Summary for SH2B1

This gene encodes a member of the SH2-domain containing mediators family. The encoded protein mediates activation of various kinases and may function in cytokine and growth factor receptor signaling and cellular transformation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]
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UniProt Comments for SH2B1

SH2-B-beta: an adaptor protein that specifically activates JAK2 and serve as adapter proteins for JAK1, -2 and -3. YXXL motifs in SH2-Bbeta are phosphorylated by JAK2, JAK1, and platelet-derived growth factor receptor and are required for membrane ruffling.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: membrane; nucleus; cytosol

Molecular Function: signal transducer activity; protein binding

Biological Process: lamellipodium biogenesis; positive regulation of mitosis; blood coagulation
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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