Mouse Anti-SH2D3C Polyclonal Antibody – Cat# MBS644864

Western Blot analysis of SH2D3C expression in transfected 293T cell line by SH2D3C polyclonal antibody. Lane 1: SH2D3C transfected lysate (77.33KD). Lane 2: Non-transfected lysate.

SH2D3C Antibody – Mouse Polyclonal

Name: SH2D3C Antibody; Polyclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS644864
Price: 880 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS644864

Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is required to induce membrane ruffling and promote EGF-dependent cell migration. More details

$880 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SH2D3C, Polyclonal Antibody

Full Product Name

SH2D3C (SH2 Domain-Containing Protein 3C, Novel SH2-Containing Protein 3, NSP3, UNQ272/PRO309/PRO34088)

Product Gene Name

anti-SH2D3C antibody

Product Synonym Names

Anti -SH2D3C (SH2 Domain-Containing Protein 3C, Novel SH2-Containing Protein 3, NSP3, UNQ272/PRO309/PRO34088)

Immunogen Sequence

MTAVGRRCPA LGSRGAAGEP EAGSDYVKFS KEKYILDSSP EKLHKELEEE LKLSSTDLRS HAWYHGRIPR EVSETLVQRN GDFLIRDSLT SLGDYVLTCR WRNQALHFKI NKVVVKAGES YTHIQYLFEQ ESFDHVPALV RYHVGSRKAV SEQSGAIIYC PVNRTFPLRY LEASYGLGQG SSKPASPVSP SGPKGSHMKR RSVTMTDGLT ADKVTRSDGC PTSTSLPRPR DSIRSCALSM DQIPDLHSPM SPISESPSSP AYSTVTRVHA APAAPSATAL PASPVARRSS EPQLCPGSAP KTHGESDKGP HTSPSHTLGK ASPSPSLSSY SDPDSGHYCQ LQPPVRGSRE WAATETSSQQ ARSYGERLKE LSENGAPEGD WGKTFTVPIV EVTSSFNPAT FQSLLIPRDN RPLEVGLLRK VKELLAEVDA RTLARHVTKV DCLVARILGV TKEMQTLMGV RWGMELLTLP HGRQLRLDLL ERFHTMSIML AVDILGCTGS AEERAALLHK TIQLAAELRG TMGNMFSFAA VMGALDMAQI SRLEQTWVTL RQRHTEGAIL YEKKLKPFLK SLNEGKEGPP LSNTTFPHVL PLITLLECDS APPEGPEPWG STEHGVEVVL AHLEAARTVA HHGGLYHTNA EVKLQGFQAR PELLEVFSTE FQMRLLWGSQ GASSSQARRY EKFDKVLTAL SHKLEPAVRS SEL

Clonality

Polyclonal

Isotype

IgG

Host

Mouse

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Recognizes human SH2D3C.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

94,411 Da

Chromosome Location

Chromosome: 9; NC_000009.11 (130500596..130541048, complement). Location: 9q34.11

OMIM

604722

3D Structure

ModBase 3D Structure for Q8N5H7

Immunogen

Full length human SH2D3C, aa1-703 (AAH27962.1).

Product Categories/Family for anti-SH2D3C antibody

Antibodies; Abs to Proteins

Applications Tested/Suitable for anti-SH2D3C antibody

Western Blot (WB)

Application Notes for anti-SH2D3C antibody

Suitable for use in Western Blot.

Other Notes

Small volumes of anti-SH2D3C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SH2D3C purchase

MBS644864 is an antibody targeting SH2D3C. Also known as SH2D3C (SH2 Domain-Containing Protein 3C, Novel SH2-Containing Protein 3, NSP3, UNQ272/PRO309/PRO34088). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for SH2D3C. It may not necessarily be applicable to this product.

NCBI GI #

356640213

NCBI GeneID

10044

NCBI Accession #

NP_001239263.1

UniProt Primary Accession #

Q8N5H7

UniProt Secondary Accession #

Q5HYE5; Q5JU31; Q6UY42; Q8N6X3; Q9Y2X5; A8K5S8; E9PG48

UniProt Related Accession #

Q8N5H7

GenBank Nucleotide #

NM_001252334.1

NCBI Official Full Name

SH2 domain-containing protein 3C isoform f

NCBI Official Synonym Full Names

SH2 domain containing 3C

NCBI Official Symbol

SH2D3C

NCBI Official Synonym Symbols

CHAT; NSP3; SHEP1; PRO34088

UniProt Protein Name

SH2 domain-containing protein 3C

UniProt Synonym Protein Names

Novel SH2-containing protein 3; SH2 domain-containing Eph receptor-binding protein 1

Protein Family

SH2 domain-containing protein

UniProt Gene Name

SH2D3C

UniProt Synonym Gene Names

NSP3; SHEP1

UniProt Entry Name

SH2D3_HUMAN

NCBI Protein Information

SH2 domain-containing protein 3C; novel SH2-containing protein 3; SH2 domain-containing Eph receptor-binding protein 1

NCBI Summary for SH2D3C

This gene encodes an adaptor protein and member of a cytoplasmic protein family involved in cell migration. The encoded protein contains a putative Src homology 2 (SH2) domain and guanine nucleotide exchange factor-like domain which allows this signaling protein to form a complex with scaffolding protein Crk-associated substrate. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

UniProt Comments for SH2D3C

SHEP1: an adaptor protein linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway. Directly links activated, tyrosine-phosphorylated Eph receptors to small Ras superfamily GTPases. Positively regulates T cell receptor-mediated interleukin-2 production by Jurkat cells.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 9q34.11

Cellular Component: membrane; cytoplasm

Molecular Function: protein binding; SH3/SH2 adaptor activity; guanyl-nucleotide exchange factor activity

Biological Process: positive regulation of signal transduction; small GTPase mediated signal transduction; JNK cascade; positive regulation of GTPase activity

Research Articles on SH2D3C

1. The structure of the NSP3-p130Cas complex reveals that this closed conformation is instrumental for interaction of NSP proteins with a focal adhesion-targeting domain present in Cas proteins.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SH2D3C antibody

Reference Product	PubMed Publications
SRC antibody	>7 publications with SH2D3C and SRC
BCAR1 antibody	>5 publications with SH2D3C and BCAR1
EPHB2 antibody	>2 publications with SH2D3C and EPHB2
NEDD9 antibody	>1 publications with SH2D3C and NEDD9

Pathways associated with anti-SH2D3C antibody

Products by Pathway	Pathway Diagram
EGFR1 Signaling Pathway antibodies	EGFR1 Signaling Pathway Diagram

Diseases associated with anti-SH2D3C antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>4 publications with SH2D3C and Neoplasms
Skin Diseases Antibodies	>3 publications with SH2D3C and Skin Diseases
Disease Models, Animal Antibodies	>1 publications with SH2D3C and Disease Models, Animal

Organs/Tissues associated with anti-SH2D3C antibody

Organ/Tissue Name	Pubmed Publications
Nerve Antibodies	>4 publications with SH2D3C and Nerve
Blood Antibodies	>4 publications with SH2D3C and Blood
Brain Antibodies	>4 publications with SH2D3C and Brain
Embryonic Tissue Antibodies	>2 publications with SH2D3C and Embryonic Tissue
Spleen Antibodies	>2 publications with SH2D3C and Spleen
Stomach Antibodies	>1 publications with SH2D3C and Stomach
Vascular Antibodies	>1 publications with SH2D3C and Vascular
Muscle Antibodies	>1 publications with SH2D3C and Muscle
Thymus Antibodies	>1 publications with SH2D3C and Thymus