Mouse Anti-CADPS2 Monoclonal Antibody – Cat# MBS644873

Detection limit for recombinant GST tagged CAPS2 is 0.3ng/ml as a capture antibody.

CADPS2 Antibody – Mouse Monoclonal

Name: CADPS2 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS644873
Price: 880 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS644873

Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells… More details

$880 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CADPS2, Monoclonal Antibody

Full Product Name

CADPS2 (Calcium-dependent Secretion Activator 2, Calcium-dependent Activator Protein for Secretion 2, CAPS-2, CAPS2, KIAA1591)

Product Gene Name

anti-CADPS2 antibody

Product Synonym Names

Anti -CADPS2 (Calcium-dependent Secretion Activator 2, Calcium-dependent Activator Protein for Secretion 2, CAPS-2, CAPS2, KIAA1591)

Immunogen Sequence

YRKSYVRKAF MKLDFNKSGS VPIINIRKCY CAKKHSQVIS GHSTEEEIKS SFLETLKVAC SKSDEVSYGE FEDYYEGLSI GIVDDEDFVN ILRTPWGI

Clonality

Monoclonal

Isotype

IgG2b,k

Clone Number

3C6

Host

Mouse

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Recognizes human CAPS2.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

147,735 Da

Chromosome Location

Chromosome: 7; NC_000007.13 (121958478..122526813, complement). Location: 7q31.3

OMIM

609978

3D Structure

ModBase 3D Structure for Q86UW7

Immunogen

Partial recombinant corresponding to aa285-383 from human CAPS2 (NP_115995) with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-CADPS2 antibody

Antibodies; Abs to Binding Proteins

Applications Tested/Suitable for anti-CADPS2 antibody

ELISA (EL/EIA)

Application Notes for anti-CADPS2 antibody

Suitable for use in ELISA.

Other Notes

Small volumes of anti-CADPS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CADPS2 purchase

MBS644873 is an antibody targeting CADPS2. Also known as CADPS2 (Calcium-dependent Secretion Activator 2, Calcium-dependent Activator Protein for Secretion 2, CAPS-2, CAPS2, KIAA1591). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CADPS2. It may not necessarily be applicable to this product.

NCBI GI #

269308219

NCBI GeneID

93664

NCBI Accession #

NP_001161412.1

UniProt Primary Accession #

Q86UW7

UniProt Secondary Accession #

Q658Q2; Q7Z5T7; Q8IZW9; Q8N7M4; Q9H6P4; Q9HCI1; Q9NWK8; A4D0X3; B7ZM56

UniProt Related Accession #

Q86UW7

GenBank Nucleotide #

NM_001167940.1

NCBI Official Full Name

calcium-dependent secretion activator 2 isoform c

NCBI Official Synonym Full Names

Ca++-dependent secretion activator 2

NCBI Official Symbol

CADPS2

UniProt Protein Name

Calcium-dependent secretion activator 2

UniProt Synonym Protein Names

Calcium-dependent activator protein for secretion 2

Protein Family

Calcium-dependent secretion activator

UniProt Gene Name

CADPS2

UniProt Synonym Gene Names

CAPS2; KIAA1591; CAPS-2

UniProt Entry Name

CAPS2_HUMAN

NCBI Protein Information

calcium-dependent secretion activator 2; CAPS-2; Ca2+-dependent activator protein for secretion 2; calcium-dependent activator protein for secretion 2

NCBI Summary for CADPS2

This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Mutations in this gene may contribute to autism susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]

UniProt Comments for CADPS2

CADPS2: Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)- dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 7q31.3

Cellular Component: presynaptic membrane; postsynaptic membrane; cytoplasmic vesicle membrane; cell junction

Molecular Function: metal ion binding; lipid binding

Biological Process: protein transport; cellular response to starvation; synaptic vesicle priming; positive regulation of exocytosis

Research Articles on CADPS2

1. This study suggested that CADPS2DeltaExon3 affects intelligence and memory in the non-clinical population.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-CADPS2 antibody

Disease Name	Pubmed Publications
Autistic Disorder Antibodies	>8 publications with CADPS2 and Autistic Disorder
Disease Models, Animal Antibodies	>3 publications with CADPS2 and Disease Models, Animal
Nervous System Diseases Antibodies	>3 publications with CADPS2 and Nervous System Diseases
Cognition Disorders Antibodies	>2 publications with CADPS2 and Cognition Disorders
Congenital Abnormalities Antibodies	>1 publications with CADPS2 and Congenital Abnormalities
Inflammation Antibodies	>1 publications with CADPS2 and Inflammation

Organs/Tissues associated with anti-CADPS2 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>14 publications with CADPS2 and Brain
Nerve Antibodies	>8 publications with CADPS2 and Nerve
Thyroid Antibodies	>1 publications with CADPS2 and Thyroid
Thymus Antibodies	>1 publications with CADPS2 and Thymus
Salivary Gland Antibodies	>1 publications with CADPS2 and Salivary Gland
Spleen Antibodies	>1 publications with CADPS2 and Spleen
Kidney Antibodies	>1 publications with CADPS2 and Kidney
Stomach Antibodies	>1 publications with CADPS2 and Stomach