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H6PD Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS644912

H6PD is 2 forms of glucose-6-phosphate dehydrogenase. G form is X-linked and H form, encoded by this gene, is autosomally linked. This H form shows activity with other hexose-6-phosphates, especially galactose-6-phosphate, whereas the G form is specific for… More details

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Product Overview

Online Datasheet in PDF
Product Name
H6PD, Polyclonal Antibody
Full Product Name
H6PD, CT (H6PD, GDH, GDH/6PGL endoplasmic bifunctional protein, Glucose 1-dehydrogenase, Hexose-6-phosphate dehydrogenase, 6-phosphogluconolactonase)
Product Gene Name
anti-H6pd antibody
Product Synonym Names
Anti -H6PD, CT (H6PD, GDH, GDH/6PGL endoplasmic bifunctional protein, Glucose 1-dehydrogenase, Hexose-6-phosphate dehydrogenase, 6-phosphogluconolactonase)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human, mouse
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
88,928 Da
Chromosome Location
Chromosome: 4; NC_000070.6 (149979481..150009023, complement). Location: 4 E2; 4 80.65 cM
3D Structure
ModBase 3D Structure for Q8CFX1
Immunogen
H6PD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 750-780 amino acids from the C-terminal region of human H6PD.

Product Categories/Family for anti-H6pd antibody

Antibodies; Abs to Enzymes; Dehydrogenase
Applications Tested/Suitable for anti-H6pd antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-H6pd antibody
Suitable for use in Western Blot, Immunohistochemistry
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:50-100

Western Blot (WB) of anti-H6pd antibody

Western blot analysis of H6PD Antibody (C-term) in mouse lung tissue lysates (35ug/lane).H6PD (arrow) was detected using the purified Pab.
Rabbit Anti-H6PD Polyclonal Antibody – Cat# MBS644912

Immunohistochemistry (IHC) of anti-H6pd antibody

H6PD Antibody (C-term) IHC analysis in formalin fixed and paraffin embedded lung tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the H6PD Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-H6PD Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS644912

Other Notes

Small volumes of anti-H6pd antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for H6pd purchase

MBS644912 is an antibody targeting H6pd. Also known as H6PD, CT (H6PD, GDH, GDH/6PGL endoplasmic bifunctional protein, Glucose 1-dehydrogenase, Hexose-6-phosphate dehydrogenase, 6-phosphogluconolactonase). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for H6pd. It may not necessarily be applicable to this product.

NCBI GI #
27503677
NCBI GeneID
100198
NCBI Accession #
AAH42677.1
UniProt Primary Accession #
Q8CFX1
UniProt Secondary Accession #
Q8BLH1; A2A7A9; B2KGW7
UniProt Related Accession #
Q8CFX1
NCBI Official Full Name
H6pd protein
NCBI Official Synonym Full Names
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
NCBI Official Symbol
H6pd
NCBI Official Synonym Symbols
Gpd1; G6pd1; Gpd-1; AI785303
UniProt Protein Name
GDH/6PGL endoplasmic bifunctional protein
UniProt Synonym Protein Names
Hexose-6-phosphate dehydrogenase
Protein Family
GDH/6PGL endoplasmic bifunctional protein
UniProt Gene Name
H6pd
UniProt Synonym Gene Names
6PGL
UniProt Entry Name
G6PE_MOUSE
NCBI Protein Information
GDH/6PGL endoplasmic bifunctional protein; glucose 1-dehydrogenase; glucose-6-phosphate dehydrogenase 1

UniProt Comments for H6pd

H6PD: Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates. Defects in H6PD are a cause of cortisone reductase deficiency (CRD). In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS).

Protein type: EC 3.1.1.31; Oxidoreductase; Hydrolase; Carbohydrate Metabolism - pentose phosphate pathway; EC 1.1.1.47

Cellular Component: mitochondrion; intracellular membrane-bound organelle; endoplasmic reticulum; cytoplasm

Molecular Function: glucose-6-phosphate dehydrogenase activity; hydrolase activity; 6-phosphogluconolactonase activity; oxidoreductase activity; glucose 1-dehydrogenase activity; carbohydrate binding; NADP binding; catalytic activity

Biological Process: pentose-phosphate shunt; metabolic process; carbohydrate metabolic process; glucose metabolic process; NADP metabolic process
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Research Articles on H6pd

1. Findings suggest that increased hepatic H6PDH and G6PT production contribute to 11beta-HSD1 upregulation of local glucocorticoid action that may be related to the development of type 2 diabetes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-H6pd antibody

 Products by Pathway  Pathway Diagram
 Pentose Phosphate Pathway antibodies  Pentose Phosphate Pathway Diagram
 Pentose Phosphate Pathway antibodies  Pentose Phosphate Pathway Diagram
 Pentose Phosphate Pathway (Pentose Phosphate Cycle) antibodies  Pentose Phosphate Pathway (Pentose Phosphate Cycle) Diagram
 Pentose Phosphate Pathway (Pentose Phosphate Cycle) antibodies  Pentose Phosphate Pathway (Pentose Phosphate Cycle) Diagram
 Pentose Phosphate Pathway, Oxidative Phase, Glucose 6P => Ribulose 5P antibodies  Pentose Phosphate Pathway, Oxidative Phase, Glucose 6P => Ribulose 5P Diagram
 Pentose Phosphate Pathway, Oxidative Phase, Glucose 6P => Ribulose 5P antibodies  Pentose Phosphate Pathway, Oxidative Phase, Glucose 6P => Ribulose 5P Diagram
 Biosynthesis Of Corticosteroids Pathway antibodies  Biosynthesis Of Corticosteroids Pathway Diagram
 Formaldehyde Oxidation I Pathway antibodies  Formaldehyde Oxidation I Pathway Diagram
 Pentose Phosphate Pathway antibodies  Pentose Phosphate Pathway Diagram
 Pentose Phosphate Pathway (oxidative Branch) antibodies  Pentose Phosphate Pathway (oxidative Branch) Diagram

Diseases associated with anti-H6pd antibody

 Disease Name  Pubmed Publications
 Cortisone reductase deficiency Antibodies  >11 publications with H6pd and Cortisone reductase deficiency
 Neoplasms Antibodies  >7 publications with H6pd and Neoplasms
 Insulin Resistance Antibodies  >7 publications with H6pd and Insulin Resistance
 Nervous System Diseases Antibodies  >3 publications with H6pd and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >2 publications with H6pd and Cardiovascular Diseases
 Muscular Diseases Antibodies  >1 publications with H6pd and Muscular Diseases
 Hypertension Antibodies  >1 publications with H6pd and Hypertension
 Liver Diseases Antibodies  >1 publications with H6pd and Liver Diseases
 Atherosclerosis Antibodies  >1 publications with H6pd and Atherosclerosis
 Prenatal Exposure Delayed Effects Antibodies  >1 publications with H6pd and Prenatal Exposure Delayed Effects

Organs/Tissues associated with anti-H6pd antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >10 publications with H6pd and Liver
 Adipose Tissue Antibodies  >7 publications with H6pd and Adipose Tissue
 Heart Antibodies  >2 publications with H6pd and Heart
 Brain Antibodies  >2 publications with H6pd and Brain
 Eye Antibodies  >1 publications with H6pd and Eye
 Pancreas Antibodies  >1 publications with H6pd and Pancreas
 Extraembryonic Tissue Antibodies  >1 publications with H6pd and Extraembryonic Tissue
 Embryonic Tissue Antibodies  >1 publications with H6pd and Embryonic Tissue
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