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WARS Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS644916

MBS644916 is an antibody targeting WARS. Also known as WARS (Tryptophan--tRNA Ligase, Cytoplasmic, Interferon-induced Protein 53, IFI53, IFP53, Tryptophanyl-tRNA Synthetase, TrpRS, hWRS, WRS). Reactive in Human. Host: Mouse. More details

$880 / 0.1 mg +1 FREE 8GB USB
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
WARS, Monoclonal Antibody
Full Product Name
WARS (Tryptophan--tRNA Ligase, Cytoplasmic, Interferon-induced Protein 53, IFI53, IFP53, Tryptophanyl-tRNA Synthetase, TrpRS, hWRS, WRS)
Product Gene Name
anti-WARS antibody
Product Synonym Names
Anti -WARS (Tryptophan--tRNA Ligase, Cytoplasmic, Interferon-induced Protein 53, IFI53, IFP53, Tryptophanyl-tRNA Synthetase, TrpRS, hWRS, WRS)
Immunogen Sequence
YKAAAGEDYK ADCPPGNPAP TSNHGPDATE AEEDFVDPWT VQTSSAKGID YDKLIVRFGS SKIDKELINR IERATGQRPH HFLRRGIFFS HRDMNQVLDA
Clonality
Monoclonal
Isotype
IgG2a,k
Clone Number
3A12
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human WARS.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
53,165 Da
Chromosome Location
Chromosome: 14; NC_000014.8 (100800125..100842680, complement). Location: 14q32.31
OMIM
191050
3D Structure
ModBase 3D Structure for P23381
Immunogen
Partial recombinant corresponding to aa50-149 from WARS (NP_004175) with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-WARS antibody

Antibodies; Abs to Enzymes; Synthase
Applications Tested/Suitable for anti-WARS antibody
ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP), Immunofluorescence (IF)
Application Notes for anti-WARS antibody
Suitable for use in Immunofluorescence, ELISA, Western Blot and Immunoprecipitation.
Dilution: Immunofluorescence: 10ug/ml

Western Blot (WB) of anti-WARS antibody

WARS monoclonal antibody, Western Blot analysis of WARS expression in HeLa.
Mouse Anti-WARS Monoclonal Antibody – Cat# MBS644916

Western Blot (WB) of anti-WARS antibody

Western Blot analysis of WARS expression in transfected 293T cell line by WARS monoclonal antibody.|Lane 1: WARS transfected lysate (53.2kD).|Lane 2: Non-transfected lysate.
Mouse Anti-WARS Monoclonal Antibody, Western Blot (WB) – Cat# MBS644916

Immunofluorescence (IF) of anti-WARS antibody

Immunofluorescence of monoclonal antibody to WARS on HeLa cell. [antibody concentration 10ug/ml]
Mouse Anti-WARS Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS644916

Immunoprecipitation (IP) of anti-WARS antibody

Immunoprecipitation of WARS transfected lysate using WARS monoclonal antibody and Protein A Magnetic Bead and immunoblotted with WARS rabbit polyclonal antibody.
Mouse Anti-WARS Monoclonal Antibody, Immunoprecipitation (IP) – Cat# MBS644916

Other Notes

Small volumes of anti-WARS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for WARS. It may not necessarily be applicable to this product.

NCBI GI #
63102455
NCBI GeneID
7453
NCBI Accession #
AAH95453.1
UniProt Primary Accession #
P23381
UniProt Secondary Accession #
P78535; Q502Y0; Q53XB6; Q9UDI5; Q9UDL3; A6NGN1; A6NID3
UniProt Related Accession #
P23381
NCBI Official Full Name
WARS protein
NCBI Official Synonym Full Names
tryptophanyl-tRNA synthetase
NCBI Official Symbol
WARS
NCBI Official Synonym Symbols
IFI53; IFP53; GAMMA-2
UniProt Protein Name
Tryptophan--tRNA ligase, cytoplasmic
UniProt Synonym Protein Names
Interferon-induced protein 53; IFP53; Tryptophanyl-tRNA synthetase
Protein Family
Tryptophan--tRNA ligase
UniProt Gene Name
WARS
UniProt Synonym Gene Names
IFI53; WRS; IFP53; TrpRS; hWRS
UniProt Entry Name
SYWC_HUMAN
NCBI Protein Information
tryptophan--tRNA ligase, cytoplasmic; hWRS; trpRS; interferon-induced protein 53; tryptophan tRNA ligase 1, cytoplasmic

NCBI Summary for WARS

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for WARS

WARS: Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression. Belongs to the class-I aminoacyl-tRNA synthetase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ligase; EC 6.1.1.2; Translation; Amino Acid Metabolism - tryptophan

Chromosomal Location of Human Ortholog: 14q32.31

Cellular Component: cytoplasm; nucleus; cytosol

Molecular Function: protein binding; tryptophan-tRNA ligase activity; ATP binding

Biological Process: negative regulation of cell proliferation; tryptophanyl-tRNA aminoacylation; tRNA aminoacylation for protein translation; translation; gene expression; angiogenesis; regulation of angiogenesis
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Research Articles on WARS

1. Naturally occurring fragments of the two proteins involved in translation, TyrRS and TrpRS, have opposing activities on angiogenesis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-WARS antibody

 Reference Product  PubMed Publications
 MARS antibody  >80 publications with WARS and MARS
 SARS antibody  >74 publications with WARS and SARS
 LARS antibody  >7 publications with WARS and LARS

Pathways associated with anti-WARS antibody

 Products by Pathway  Pathway Diagram
 Aminoacyl-tRNA Biosynthesis Pathway antibodies  Aminoacyl-tRNA Biosynthesis Pathway Diagram
 Aminoacyl-tRNA Biosynthesis Pathway antibodies  Aminoacyl-tRNA Biosynthesis Pathway Diagram
 Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway antibodies  Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway Diagram
 Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway antibodies  Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway Diagram
 Cytosolic TRNA Aminoacylation Pathway antibodies  Cytosolic TRNA Aminoacylation Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Tryptophan Metabolism Pathway antibodies  Tryptophan Metabolism Pathway Diagram
 TRNA Aminoacylation Pathway antibodies  TRNA Aminoacylation Pathway Diagram

Diseases associated with anti-WARS antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >2647 publications with WARS and Neoplasms
 Cardiovascular Diseases Antibodies  >1547 publications with WARS and Cardiovascular Diseases
 Brain Diseases Antibodies  >1461 publications with WARS and Brain Diseases
 Pain Antibodies  >851 publications with WARS and Pain
 Liver Diseases Antibodies  >348 publications with WARS and Liver Diseases
 Inflammation Antibodies  >318 publications with WARS and Inflammation
 Hypertension Antibodies  >302 publications with WARS and Hypertension
 Kidney Diseases Antibodies  >251 publications with WARS and Kidney Diseases
 Breast Neoplasms Antibodies  >250 publications with WARS and Breast Neoplasms
 Memory Disorders Antibodies  >239 publications with WARS and Memory Disorders

Organs/Tissues associated with anti-WARS antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2892 publications with WARS and Blood
 Brain Antibodies  >2660 publications with WARS and Brain
 Bone Antibodies  >1183 publications with WARS and Bone
 Heart Antibodies  >932 publications with WARS and Heart
 Skin Antibodies  >914 publications with WARS and Skin
 Lung Antibodies  >860 publications with WARS and Lung
 Vascular Antibodies  >808 publications with WARS and Vascular
 Nerve Antibodies  >756 publications with WARS and Nerve
 Eye Antibodies  >717 publications with WARS and Eye
 Muscle Antibodies  >490 publications with WARS and Muscle
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