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SRGAP1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS644943

MBS644943 is an antibody targeting SRGAP1. Also known as SRGAP1 (SLIT-ROBO Rho GTPase-activating Protein 1, srGAP1, Rho GTPase-activating Protein 13, ARHGAP13, KIAA1304). Reactive in Human. Host: Mouse. More details

$880 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SRGAP1, Monoclonal Antibody
Full Product Name
SRGAP1 (SLIT-ROBO Rho GTPase-activating Protein 1, srGAP1, Rho GTPase-activating Protein 13, ARHGAP13, KIAA1304)
Product Gene Name
anti-SRGAP1 antibody
Product Synonym Names
Anti -SRGAP1 (SLIT-ROBO Rho GTPase-activating Protein 1, srGAP1, Rho GTPase-activating Protein 13, ARHGAP13, KIAA1304)
Immunogen Sequence
PLDPETIAQD IEETMNTALN ELRELERQST AKHAPDVVLD TLEQVKNSPT PATSTESLSP LHNVALRSSE PQIRRSTSSS SDTMSTFKPM VAPRMGVQL
Clonality
Monoclonal
Isotype
IgG2a,k
Clone Number
5D2
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human SRGAP1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
124,264 Da
Chromosome Location
Chromosome: 12; NC_000012.11 (64238276..64541643). Location: 12q14.2
OMIM
606523
3D Structure
ModBase 3D Structure for Q7Z6B7
Immunogen
Partial recombinant corresponding to aa952-1051 from human SRGAP1 (NP_065813) with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-SRGAP1 antibody

Antibodies; Abs to GTPase; Rab; Ras; Rho Proteins
Applications Tested/Suitable for anti-SRGAP1 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-SRGAP1 antibody
Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 3ug/ml

Western Blot (WB) of anti-SRGAP1 antibody

Western Blot detection against Immunogen (37kD).
Mouse Anti-SRGAP1 Monoclonal Antibody – Cat# MBS644943

Immunohistochemistry (IHC) of anti-SRGAP1 antibody

Immunoperoxidase of monoclonal antibody to SRGAP1 on formalin-fixed paraffin-embedded human salivary gland. [antibody concentration 3ug/ml].
Mouse Anti-SRGAP1 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS644943

Testing Data of anti-SRGAP1 antibody

Detection limit for recombinant GST tagged SRGAP1 is ~0.1ng/ml as a capture antibody.
Mouse Anti-SRGAP1 Monoclonal Antibody, Testing Data – Cat# MBS644943

Other Notes

Small volumes of anti-SRGAP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SRGAP1. It may not necessarily be applicable to this product.

NCBI GI #
44917604
NCBI GeneID
57522
NCBI Accession #
NP_065813.1
UniProt Primary Accession #
Q7Z6B7
UniProt Secondary Accession #
Q9H8A3; Q9P2P2
UniProt Related Accession #
Q7Z6B7
GenBank Nucleotide #
NM_020762.2
NCBI Official Full Name
SLIT-ROBO Rho GTPase-activating protein 1
NCBI Official Synonym Full Names
SLIT-ROBO Rho GTPase activating protein 1
NCBI Official Symbol
SRGAP1
NCBI Official Synonym Symbols
ARHGAP13
UniProt Protein Name
SLIT-ROBO Rho GTPase-activating protein 1
UniProt Synonym Protein Names
Rho GTPase-activating protein 13
Protein Family
SLIT-ROBO Rho GTPase-activating protein
UniProt Gene Name
SRGAP1
UniProt Synonym Gene Names
ARHGAP13; KIAA1304; srGAP1
UniProt Entry Name
SRGP1_HUMAN
NCBI Protein Information
SLIT-ROBO Rho GTPase-activating protein 1; rho GTPase-activating protein 13

UniProt Comments for SRGAP1

ARHGAP13: GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs, Rac/Rho; GAPs

Chromosomal Location of Human Ortholog: 12q14.2

Cellular Component: cytoplasm; cytosol

Molecular Function: protein binding; Rac GTPase binding

Biological Process: axon guidance; cell migration; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; negative regulation of cell migration; Rho protein signal transduction

Disease: Thyroid Carcinoma, Follicular
Show more

Research Articles on SRGAP1

1. genome-wide linkage analysis in populations in Ohio and Poland: Data suggest that missense mutations in SRGAP1 are associated with genetic predisposition to papillary thyroid carcinoma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SRGAP1 antibody

 Reference Product  PubMed Publications
 CDC42 antibody  >5 publications with SRGAP1 and CDC42
 ROBO1 antibody  >3 publications with SRGAP1 and ROBO1
 RHOA antibody  >2 publications with SRGAP1 and RHOA
 RAC1 antibody  >2 publications with SRGAP1 and RAC1
 ROBO2 antibody  >1 publications with SRGAP1 and ROBO2
 SLIT2 antibody  >1 publications with SRGAP1 and SLIT2

Pathways associated with anti-SRGAP1 antibody

 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Inactivation Of Cdc42 And Rac Pathway antibodies  Inactivation Of Cdc42 And Rac Pathway Diagram
 Inactivation Of Cdc42 And Rac Pathway antibodies  Inactivation Of Cdc42 And Rac Pathway Diagram
 Regulation Of RhoA Activity Pathway antibodies  Regulation Of RhoA Activity Pathway Diagram
 Rho GTPase Cycle Pathway antibodies  Rho GTPase Cycle Pathway Diagram

Diseases associated with anti-SRGAP1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >3 publications with SRGAP1 and Neoplasms
 Lung Diseases Antibodies  >2 publications with SRGAP1 and Lung Diseases
 Head and Neck Neoplasms Antibodies  >1 publications with SRGAP1 and Head and Neck Neoplasms
 Nervous System Diseases Antibodies  >1 publications with SRGAP1 and Nervous System Diseases
 Pneumonia Antibodies  >1 publications with SRGAP1 and Pneumonia
 Lung Neoplasms Antibodies  >1 publications with SRGAP1 and Lung Neoplasms
 Inflammation Antibodies  >1 publications with SRGAP1 and Inflammation

Organs/Tissues associated with anti-SRGAP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >3 publications with SRGAP1 and Embryonic Tissue
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