Rabbit Anti-TAX1BP1 Polyclonal Antibody – Cat# MBS644950

TAX1BP1 Antibody (Center) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the TAX1BP1 antibody detected the TAX1BP1 protein (arrow).

TAX1BP1 Antibody – Rabbit Polyclonal

Name: TAX1BP1 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS644950
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS644950

The HTLV-1 Tax protein transcriptionally activates the HTLV-1 promoter. Tax also binds to and stimulates the expression of cellular genes, including transcription factors and other proteins (Gachon et al., 1998 [PubMed 9733879]). More details

$895 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TAX1BP1, Polyclonal Antibody

Full Product Name

TAX1BP1, ID (TAX1BP1, T6BP, Tax1-binding protein 1, TRAF6-binding protein)

Product Gene Name

anti-TAX1BP1 antibody

Product Synonym Names

Anti -TAX1BP1, ID (TAX1BP1, T6BP, Tax1-binding protein 1, TRAF6-binding protein)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Human

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

90,877 Da

Chromosome Location

Chromosome: 7; NC_000007.13 (27778992..27869386). Location: 7p15

OMIM

605326

3D Structure

ModBase 3D Structure for Q86VP1

Immunogen

TAX1BP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 399-429 amino acids from the Central region of human TAX1BP1.

Product Categories/Family for anti-TAX1BP1 antibody

Antibodies; Abs to Binding Proteins

Applications Tested/Suitable for anti-TAX1BP1 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-TAX1BP1 antibody

Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Other Notes

Small volumes of anti-TAX1BP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TAX1BP1 purchase

MBS644950 is an antibody targeting TAX1BP1. Also known as TAX1BP1, ID (TAX1BP1, T6BP, Tax1-binding protein 1, TRAF6-binding protein). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TAX1BP1. It may not necessarily be applicable to this product.

NCBI GI #

332634744

NCBI GeneID

8887

NCBI Accession #

NP_001193831.1

UniProt Primary Accession #

Q86VP1

UniProt Secondary Accession #

O60398; O95770; Q13311; Q9BQG5; Q9UI88; B4DKU7; E7ENV2

UniProt Related Accession #

Q86VP1

GenBank Nucleotide #

NM_001206902.1

NCBI Official Full Name

tax1-binding protein 1 isoform 3

NCBI Official Synonym Full Names

Tax1 (human T-cell leukemia virus type I) binding protein 1

NCBI Official Symbol

TAX1BP1

NCBI Official Synonym Symbols

T6BP; TXBP151; CALCOCO3

UniProt Protein Name

Tax1-binding protein 1

UniProt Synonym Protein Names

TRAF6-binding protein

Protein Family

Tax1-binding protein

UniProt Gene Name

TAX1BP1

UniProt Synonym Gene Names

T6BP

UniProt Entry Name

TAXB1_HUMAN

NCBI Protein Information

tax1-binding protein 1; TRAF6-binding protein

NCBI Summary for TAX1BP1

This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]

UniProt Comments for TAX1BP1

TAX1BP1: Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade. Homooligomer. Interacts with TRAF6 in a IL-1-dependent manner. Interacts with TNFAIP3. Interacts with STARD13. Interacts with the HTLV-1 protein Tax-1. Expressed in all tissues tested. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis

Chromosomal Location of Human Ortholog: 7p15

Cellular Component: cytosol

Molecular Function: protein binding; metal ion binding; kinase binding

Biological Process: inhibition of NF-kappaB transcription factor; apoptosis; innate immune response; negative regulation of interferon type I production; negative regulation of apoptosis

Research Articles on TAX1BP1

1. RNF11 functions together with TAX1BP1 to restrict antiviral signaling and IFN-beta production.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TAX1BP1 antibody

Reference Product	PubMed Publications
TRAF6 antibody	>13 publications with TAX1BP1 and TRAF6
TNFAIP3 antibody	>12 publications with TAX1BP1 and TNFAIP3
JUN antibody	>9 publications with TAX1BP1 and JUN
RNF11 antibody	>7 publications with TAX1BP1 and RNF11
TBK1 antibody	>4 publications with TAX1BP1 and TBK1
IKBKE antibody	>3 publications with TAX1BP1 and IKBKE
RIPK1 antibody	>2 publications with TAX1BP1 and RIPK1
RALBP1 antibody	>1 publications with TAX1BP1 and RALBP1

Pathways associated with anti-TAX1BP1 antibody

Products by Pathway	Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
Negative Regulators Of RIG-I/MDA5 Signaling Pathway antibodies	Negative Regulators Of RIG-I/MDA5 Signaling Pathway Diagram
RIG-I/MDA5 Mediated Induction Of IFN-alpha/beta Pathways antibodies	RIG-I/MDA5 Mediated Induction Of IFN-alpha/beta Pathways Diagram

Diseases associated with anti-TAX1BP1 antibody

Disease Name	Pubmed Publications
Necrosis Antibodies	>14 publications with TAX1BP1 and Necrosis
Inflammation Antibodies	>13 publications with TAX1BP1 and Inflammation
Neoplasms Antibodies	>8 publications with TAX1BP1 and Neoplasms
Nervous System Diseases Antibodies	>4 publications with TAX1BP1 and Nervous System Diseases
Carcinoma, Hepatocellular Antibodies	>3 publications with TAX1BP1 and Carcinoma, Hepatocellular
Fibrosis Antibodies	>2 publications with TAX1BP1 and Fibrosis
Liver Neoplasms Antibodies	>1 publications with TAX1BP1 and Liver Neoplasms
Poisoning Antibodies	>1 publications with TAX1BP1 and Poisoning
Adenocarcinoma Antibodies	>1 publications with TAX1BP1 and Adenocarcinoma
Disease Models, Animal Antibodies	>1 publications with TAX1BP1 and Disease Models, Animal

Organs/Tissues associated with anti-TAX1BP1 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>8 publications with TAX1BP1 and Blood
Liver Antibodies	>5 publications with TAX1BP1 and Liver
Eye Antibodies	>3 publications with TAX1BP1 and Eye
Muscle Antibodies	>2 publications with TAX1BP1 and Muscle
Bone Antibodies	>2 publications with TAX1BP1 and Bone
Bone Marrow Antibodies	>2 publications with TAX1BP1 and Bone Marrow
Lung Antibodies	>2 publications with TAX1BP1 and Lung
Brain Antibodies	>2 publications with TAX1BP1 and Brain
Heart Antibodies	>1 publications with TAX1BP1 and Heart
Trachea Antibodies	>1 publications with TAX1BP1 and Trachea