Rabbit Anti-RNLS Polyclonal Antibody – Cat# MBS645037

Western Blot analysis of C10orf59 expression in transfected 293T cell line by C10orf59 polyclonal antibody. Lane 1: C10orf59 transfected lysate (37.8kD). Lane 2: Non-transfected lysate.

RNLS Antibody – Rabbit Polyclonal

Name: RNLS Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS645037
Price: 970 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS645037

Probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. Degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. Lowers blood pressure in vivo… More details

$970 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

RNLS, Polyclonal Antibody

Full Product Name

RNLS (Renalase, Monoamine Oxidase-C, MAO-C, C10orf59, FLJ11218)

Product Gene Name

anti-RNLS antibody

Product Synonym Names

Anti -RNLS (Renalase, Monoamine Oxidase-C, MAO-C, C10orf59, FLJ11218)

Immunogen Sequence

MAQVLIVGAG MTGSLCAALL RRQTSGPLYL AVWDKADDSG GRMTTACSPH NPQCTADLGA QYITCTPHYA KKHQRFYDEL LAYGVLRPLS SPIEGMVMKE GDCNFVAPQG ISSIIKHYLK ESGAEVYFRH RVTQINLRDD KWEVSKQTGS PEQFDLIVLT MPVPEILQLQ GDITTLISEC QRQQLEAVSY SSRYALGLFY EAGTKIDVPW AGQYITSNPC IRFVSIDNKK RNIESSEIGP SLVIHTTVPF GVTYLEHSIE DVQELVFQQL ENILPGLPQP IATKCQKWRH SQVTNAAANC PGQMTLHHKP FLACGGDGFT QSNFDGCITS ALCVLEALKN YI

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Recognizes human C10orf59.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

37,847 Da

Chromosome Location

Chromosome: 10; NC_000010.10 (90033621..90343611, complement). Location: 10q23.31

OMIM

609360

3D Structure

ModBase 3D Structure for Q5VYX0

Immunogen

Full length human C10orf59, aa1-342 (NP_001026879.1).

Product Categories/Family for anti-RNLS antibody

Antibodies; Abs to Enzymes

Applications Tested/Suitable for anti-RNLS antibody

Western Blot (WB)

Application Notes for anti-RNLS antibody

Suitable for use in Western Blot.

Other Notes

Small volumes of anti-RNLS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RNLS purchase

MBS645037 is an antibody targeting RNLS. Also known as RNLS (Renalase, Monoamine Oxidase-C, MAO-C, C10orf59, FLJ11218). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for RNLS. It may not necessarily be applicable to this product.

NCBI GI #

237649117

NCBI GeneID

55328

NCBI Accession #

NP_001026879.2

UniProt Primary Accession #

Q5VYX0

UniProt Secondary Accession #

Q9BS33; Q9NUP8

UniProt Related Accession #

Q5VYX0

GenBank Nucleotide #

NM_001031709.2

NCBI Official Full Name

renalase isoform 1

NCBI Official Synonym Full Names

renalase, FAD-dependent amine oxidase

NCBI Official Symbol

RNLS

NCBI Official Synonym Symbols

C10orf59; RENALASE

UniProt Protein Name

Renalase

UniProt Synonym Protein Names

Monoamine oxidase-C

UniProt Gene Name

RNLS

UniProt Synonym Gene Names

C10orf59; MAO-C

UniProt Entry Name

RNLS_HUMAN

NCBI Protein Information

renalase; MAO-C; monoamine oxidase-C

NCBI Summary for RNLS

Renalase is a flavin adenine dinucleotide-dependent amine oxidase that is secreted into the blood from the kidney (Xu et al., 2005 [PubMed 15841207]).[supplied by OMIM, Mar 2008]

UniProt Comments for RNLS

RENALASE: Probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. Degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis. According to PubMed:17385068, is unlikely that renalase has physiologically relevant catecholamine-oxidizing activity. Belongs to the renalase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; EC 1.6.3.5; Oxidoreductase; Secreted

Chromosomal Location of Human Ortholog: 10q23.31

Cellular Component: extracellular space

Molecular Function: oxidoreductase activity

Biological Process: heart contraction; regulation of systemic arterial blood pressure; epinephrine metabolic process; phosphate ion homeostasis; norepinephrine metabolic process; dopamine metabolic process

Research Articles on RNLS

1. Renalase is elevated among heart transplant recipients and is predominantly dependent on renal function

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-RNLS antibody

Products by Pathway	Pathway Diagram
Noradrenaline And Adrenaline Degradation Pathway antibodies	Noradrenaline And Adrenaline Degradation Pathway Diagram

Diseases associated with anti-RNLS antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>3 publications with RNLS and Neoplasms
Neoplasm Metastasis Antibodies	>2 publications with RNLS and Neoplasm Metastasis
Breast Neoplasms Antibodies	>2 publications with RNLS and Breast Neoplasms
Inflammation Antibodies	>2 publications with RNLS and Inflammation
Hypertension Antibodies	>1 publications with RNLS and Hypertension
Cardiovascular Diseases Antibodies	>1 publications with RNLS and Cardiovascular Diseases

Organs/Tissues associated with anti-RNLS antibody

Organ/Tissue Name	Pubmed Publications
Eye Antibodies	>1 publications with RNLS and Eye