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PARL Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS645069

Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals By similarity. Promotes… More details

$935 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
PARL, Polyclonal Antibody
Full Product Name
PARL, NT (Presenilins-associated Rhomboid-like Protein, Mitochondrial, Mitochondrial Intramembrane Cleaving Protease PARL, PSARL, PRO2207)
Product Gene Name
anti-PARL antibody
Product Synonym Names
Anti -PARL, NT (Presenilins-associated Rhomboid-like Protein, Mitochondrial, Mitochondrial Intramembrane Cleaving Protease PARL, PSARL, PRO2207)
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.02% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human PARL. Species sequence homology: Mouse, rat.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
42,190 Da
Chromosome Location
Chromosome: 3; NC_000003.11 (183543522..183602693, complement). Location: 3q27.1
OMIM
607858
3D Structure
ModBase 3D Structure for Q9H300
Immunogen
Synthetic peptide corresponding to aa15 in human PARL at N-terminal conjugated to KLH.

Product Categories/Family for anti-PARL antibody

Antibodies; Abs to Mitochondrial Proteins
Applications Tested/Suitable for anti-PARL antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-PARL antibody
Suitable for use in Western Blot and Immunohistochemistry.
Dilution: Western Blot: 1-2ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml

Immunohistochemistry (IHC) of anti-PARL antibody

Human Pancreas: Formalin- Fixed, Paraffin-Embedded (FFPE)
Rabbit Anti-PARL Polyclonal Antibody – Cat# MBS645069

Western Blot (WB) of anti-PARL antibody

Western blot analysis of PARL in 3T3 cell lysate with PARL antibody at (A) 1 and (B) 2ug/ml.
Rabbit Anti-PARL Polyclonal Antibody, Western Blot (WB) – Cat# MBS645069

Other Notes

Small volumes of anti-PARL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PARL purchase

MBS645069 is an antibody targeting PARL. Also known as PARL, NT (Presenilins-associated Rhomboid-like Protein, Mitochondrial, Mitochondrial Intramembrane Cleaving Protease PARL, PSARL, PRO2207). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PARL. It may not necessarily be applicable to this product.

NCBI GI #
20127652
NCBI GeneID
55486
NCBI Accession #
NP_061092.3
UniProt Primary Accession #
Q9H300
UniProt Secondary Accession #
Q96CQ4; Q9BTJ6; Q9P1E3
UniProt Related Accession #
Q9H300
GenBank Nucleotide #
NM_018622.5
NCBI Official Full Name
presenilins-associated rhomboid-like protein, mitochondrial isoform 1 preproprotein
NCBI Official Synonym Full Names
presenilin associated, rhomboid-like
NCBI Official Symbol
PARL
NCBI Official Synonym Symbols
PSARL; PSARL1; RHBDS1; PRO2207; PSENIP2
UniProt Protein Name
Presenilins-associated rhomboid-like protein, mitochondrial
UniProt Synonym Protein Names
Mitochondrial intramembrane cleaving protease PARL
Protein Family
Presenilins-associated rhomboid-like protein
UniProt Gene Name
PARL
UniProt Synonym Gene Names
PSARL; Pbeta
UniProt Entry Name
PARL_HUMAN
NCBI Protein Information
presenilins-associated rhomboid-like protein, mitochondrial; rhomboid 7 homolog 1; mitochondrial intramembrane cleaving protease PARL; mitochondrial intramembrane-cleaving protease PARL

NCBI Summary for PARL

This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
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UniProt Comments for PARL

PSARL: a mitochondrial intramembrane protease that is associated with insulin resistance and type 2 diabetes. Induced in humans by caloric restriction. Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals. Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain. Induced in humans by caloric restriction. Interacts with PSEN1 and PSEN2. Binds OPA1. Two isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Protease; Membrane protein, multi-pass; Apoptosis; EC 3.4.21.105; Mitochondrial

Chromosomal Location of Human Ortholog: 3q27.1

Cellular Component: mitochondrion; mitochondrial inner membrane; integral to membrane; nucleus

Molecular Function: protein binding; serine-type endopeptidase activity; endopeptidase activity

Biological Process: membrane protein proteolysis; proteolysis
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Research Articles on PARL

1. Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PARL antibody

 Reference Product  PubMed Publications
 HAX1 antibody  >2 publications with PARL and HAX1

Diseases associated with anti-PARL antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >58 publications with PARL and Neoplasms
 Death Antibodies  >13 publications with PARL and Death
 Nervous System Diseases Antibodies  >11 publications with PARL and Nervous System Diseases
 Disease Models, Animal Antibodies  >5 publications with PARL and Disease Models, Animal
 Kidney Diseases Antibodies  >3 publications with PARL and Kidney Diseases
 Necrosis Antibodies  >3 publications with PARL and Necrosis
 Precancerous Conditions Antibodies  >2 publications with PARL and Precancerous Conditions
 Weight Loss Antibodies  >1 publications with PARL and Weight Loss
 Anemia, Hemolytic Antibodies  >1 publications with PARL and Anemia, Hemolytic
 Hypertrophy Antibodies  >1 publications with PARL and Hypertrophy

Organs/Tissues associated with anti-PARL antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >24 publications with PARL and Blood
 Brain Antibodies  >22 publications with PARL and Brain
 Muscle Antibodies  >9 publications with PARL and Muscle
 Vascular Antibodies  >7 publications with PARL and Vascular
 Heart Antibodies  >5 publications with PARL and Heart
 Eye Antibodies  >5 publications with PARL and Eye
 Uterus Antibodies  >4 publications with PARL and Uterus
 Nerve Antibodies  >3 publications with PARL and Nerve
 Prostate Antibodies  >2 publications with PARL and Prostate
 Liver Antibodies  >2 publications with PARL and Liver
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