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ITGB1BP3 (NMRK2) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS645081

MBS645081 is an antibody targeting NMRK2. Also known as ITGB1BP3, ID (NMRK2, ITGB1BP3, NRK2, Nicotinamide riboside kinase 2, Integrin beta-1-binding protein 3, Muscle integrin-binding protein, Nicotinic acid riboside kinase 2, Ribosylnicotinamide kinase 2,… More details

$895 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ITGB1BP3 (NMRK2), Polyclonal Antibody
Full Product Name
ITGB1BP3, ID (NMRK2, ITGB1BP3, NRK2, Nicotinamide riboside kinase 2, Integrin beta-1-binding protein 3, Muscle integrin-binding protein, Nicotinic acid riboside kinase 2, Ribosylnicotinamide kinase 2, Ribosylnicotinic acid kinase 2)
Product Gene Name
anti-NMRK2 antibody
Product Synonym Names
Anti -ITGB1BP3, ID (NMRK2, ITGB1BP3, NRK2, Nicotinamide riboside kinase 2, Integrin beta-1-binding protein 3, Muscle integrin-binding protein, Nicotinic acid riboside kinase 2, Ribosylnicotinamide kinase 2, Ribosylnicotinic acid kinase 2)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Purified
Purified by saturated ammonium sulfate precipitation followed by dialysis against PBS.
Specificity
Human, mouse
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
26,046 Da
Chromosome Location
Chromosome: 19; NC_000019.9 (3933101..3942414). Location: 19p13.3
OMIM
608705
3D Structure
ModBase 3D Structure for Q9NPI5
Immunogen
ITGB1BP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 164-194 amino acids from the Central region of human ITGB1BP3.

Product Categories/Family for anti-NMRK2 antibody

Antibodies; Abs to Protein Kinases
Applications Tested/Suitable for anti-NMRK2 antibody
ELISA (EL/EIA), Western Blot (WB), Flow Cytometry (FC/FACS)
Application Notes for anti-NMRK2 antibody
Suitable for use in Western Blot, Flow Cytometry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:50-100
Flow Cytometry: 1:10-50

Western Blot (WB) of anti-NMRK2 antibody

Western Blot analysis in mouse testis tissue lysates (35ug/lane) using MBS645081. This demonstrates that MBS645081 detects the ITGB1BP3 protein (arrow).
Rabbit Anti-NMRK2 Polyclonal Antibody – Cat# MBS645081

Flow Cytometry (FC/FACS) of anti-NMRK2 antibody

Flow Cytometry analysis of CEM cells using MBS645081 (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-NMRK2 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS645081

Other Notes

Small volumes of anti-NMRK2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for NMRK2. It may not necessarily be applicable to this product.

NCBI GI #
219518783
NCBI GeneID
27231
NCBI Accession #
AAI43330.1
UniProt Primary Accession #
Q9NPI5
UniProt Secondary Accession #
Q52M81; Q9NZK3
UniProt Related Accession #
Q9NPI5
NCBI Official Full Name
ITGB1BP3 protein
NCBI Official Synonym Full Names
nicotinamide riboside kinase 2
NCBI Official Symbol
NMRK2
NCBI Official Synonym Symbols
MIBP; NRK2; ITGB1BP3
UniProt Protein Name
Nicotinamide riboside kinase 2
UniProt Synonym Protein Names
Integrin beta-1-binding protein 3; Muscle integrin-binding protein; MIBP; Nicotinic acid riboside kinase 2 (EC:2.7.1.173); Ribosylnicotinamide kinase 2; RNK 2; Ribosylnicotinic acid kinase 2
Protein Family
Nicotinamide riboside kinase
UniProt Gene Name
NMRK2
UniProt Synonym Gene Names
ITGB1BP3; NRK2; NRK 2; NmR-K 2; MIBP; RNK 2
UniProt Entry Name
NRK2_HUMAN
NCBI Protein Information
nicotinamide riboside kinase 2; NRK 2; RNK 2; nmR-K 2; ribosylnicotinamide kinase 2; ribosylnicotinic acid kinase 2; muscle integrin-binding protein; nicotinic acid riboside kinase 2; integrin beta 1 binding protein 3; integrin beta-1-binding protein 3; muscle-specific beta 1 integrin binding protein

UniProt Comments for NMRK2

ITGB1BP3: an enzyme that catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside to form nicotinamide mononucleotide and nicotinic acid mononucleotide. Reduces laminin matrix deposition and cell adhesion to laminin, but not to fibronectin. Interacts with ITGB1 alone or when associated with alpha-7, but not with alpha-5. Involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation. Predominantly expressed in skeletal muscle and, at a much lower level, in the heart (at protein level). No expression in brain, kidney, liver, lung, pancreas nor placenta. May play a role in the regulation of terminal myogenesis. Two alternatively spliced human isoforms have been described.

Protein type: EC 2.7.1.173; Cell development/differentiation; Kinase, other; EC 2.7.1.22; Cell adhesion

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: intracellular

Molecular Function: protein binding; ribosylnicotinamide kinase activity; metal ion binding; ATP binding

Biological Process: NAD biosynthetic process; negative regulation of myoblast differentiation; phosphorylation
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NMRK2 antibody

 Reference Product  PubMed Publications
 ST7 antibody  >1 publications with NMRK2 and ST7
 LRP12 antibody  >1 publications with NMRK2 and LRP12

Pathways associated with anti-NMRK2 antibody

 Products by Pathway  Pathway Diagram
 NAD Salvage Pathway II antibodies  NAD Salvage Pathway II Diagram
 NAD Salvage Pathway III antibodies  NAD Salvage Pathway III Diagram
 Nicotinate And Nicotinamide Metabolism Pathway antibodies  Nicotinate And Nicotinamide Metabolism Pathway Diagram
 Nicotinate And Nicotinamide Metabolism Pathway antibodies  Nicotinate And Nicotinamide Metabolism Pathway Diagram

Organs/Tissues associated with anti-NMRK2 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >2 publications with NMRK2 and Muscle
 Heart Antibodies  >2 publications with NMRK2 and Heart
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