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IFT172 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS645093

MBS645093 is an antibody targeting IFT172. Also known as IFT172, NT (IFT172, KIAA1179, Intraflagellar transport protein 172 homolog). Reactive in Human, Mouse. Host: Rabbit. More details

$895 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
IFT172, Polyclonal Antibody
Full Product Name
IFT172, NT (IFT172, KIAA1179, Intraflagellar transport protein 172 homolog)
Product Gene Name
anti-IFT172 antibody
Product Synonym Names
Anti -IFT172, NT (IFT172, KIAA1179, Intraflagellar transport protein 172 homolog)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human, mouse
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
197,576 Da
Chromosome Location
Chromosome: 2; NC_000002.11 (27667240..27712575, complement). Location: 2p23.3
OMIM
607386
3D Structure
ModBase 3D Structure for Q9UG01
Immunogen
IFT172 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 35-64 amino acids from the N-terminal region of human IFT172.

Product Categories/Family for anti-IFT172 antibody

Antibodies; Abs to Transport Proteins
Applications Tested/Suitable for anti-IFT172 antibody
ELISA (EL/EIA), Western Blot (WB), Flow Cytometry (FC/FACS)
Application Notes for anti-IFT172 antibody
Suitable for use in Western Blot, Flow Cytometry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Flow Cytometry: 1:10-50

Western Blot (WB) of anti-IFT172 antibody

IFT172 Antibody (N-term) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the IFT172 antibody detected IFT172 protein (arrow).
Rabbit Anti-IFT172 Polyclonal Antibody – Cat# MBS645093

Flow Cytometry (FC/FACS) of anti-IFT172 antibody

IFT172 Antibody (N-term) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-IFT172 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS645093

Other Notes

Small volumes of anti-IFT172 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for IFT172. It may not necessarily be applicable to this product.

NCBI GI #
148744406
NCBI GeneID
26160
NCBI Accession #
AAI42730.1
UniProt Primary Accession #
Q9UG01
UniProt Secondary Accession #
Q86X44; Q96HW4; Q9UFJ9; Q9ULP1; B2RNU5
UniProt Related Accession #
Q9UG01
NCBI Official Full Name
IFT172 protein
NCBI Official Synonym Full Names
intraflagellar transport 172 homolog (Chlamydomonas)
NCBI Official Symbol
IFT172
NCBI Official Synonym Symbols
SLB; wim; osm-1; NPHP17
UniProt Protein Name
Intraflagellar transport protein 172 homolog
Protein Family
Intraflagellar transport protein
UniProt Gene Name
IFT172
UniProt Synonym Gene Names
KIAA1179
UniProt Entry Name
IF172_HUMAN
NCBI Protein Information
intraflagellar transport protein 172 homolog; wimple homolog; selective LIM binding factor homolog

NCBI Summary for IFT172

This gene encodes a subunit of the intraflagellar transport subcomplex IFT-B. Subcomplexes IFT-A and IFT-B are necessary for ciliary assembly and maintenance. Mutations in this gene have been associated with skeletal ciliopathies, with or without polydactyly, such as such short-rib thoracic dysplasias 1, 9 or 10. [provided by RefSeq, Mar 2014]
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UniProt Comments for IFT172

IFT172: Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway. Belongs to the IFT172 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 2p23.3

Cellular Component: axoneme; vesicle; cilium

Biological Process: limb development; epidermis development; Notch signaling pathway; smoothened signaling pathway; organelle organization and biogenesis; palate development; spinal cord motor neuron differentiation; cytoplasmic microtubule organization and biogenesis; dorsal/ventral pattern formation; neural tube closure; positive regulation of smoothened signaling pathway; cilium biogenesis; protein processing; heart looping; brain development; negative regulation of epithelial cell proliferation

Disease: Short-rib Thoracic Dysplasia 10 With Or Without Polydactyly; Retinitis Pigmentosa 71
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Research Articles on IFT172

1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IFT172 antibody

 Reference Product  PubMed Publications
 IFT88 antibody  >9 publications with IFT172 and IFT88
 KIF3A antibody  >5 publications with IFT172 and KIF3A
 IFT20 antibody  >3 publications with IFT172 and IFT20
 IFT52 antibody  >3 publications with IFT172 and IFT52
 GLI3 antibody  >3 publications with IFT172 and GLI3
 IFT81 antibody  >1 publications with IFT172 and IFT81
 CREB1 antibody  >1 publications with IFT172 and CREB1
 GLI2 antibody  >1 publications with IFT172 and GLI2

Pathways associated with anti-IFT172 antibody

 Products by Pathway  Pathway Diagram
 Hedgehog Signaling Events Mediated By Gli Proteins Pathway antibodies  Hedgehog Signaling Events Mediated By Gli Proteins Pathway Diagram

Diseases associated with anti-IFT172 antibody

 Disease Name  Pubmed Publications
 Heart Defects, Congenital Antibodies  >2 publications with IFT172 and Heart Defects, Congenital
 Liver Diseases Antibodies  >1 publications with IFT172 and Liver Diseases
 Craniofacial Abnormalities Antibodies  >1 publications with IFT172 and Craniofacial Abnormalities
 Nervous System Malformations Antibodies  >1 publications with IFT172 and Nervous System Malformations
 Edema Antibodies  >1 publications with IFT172 and Edema

Organs/Tissues associated with anti-IFT172 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >3 publications with IFT172 and Kidney
 Brain Antibodies  >3 publications with IFT172 and Brain
 Eye Antibodies  >2 publications with IFT172 and Eye
 Heart Antibodies  >2 publications with IFT172 and Heart
 Embryonic Tissue Antibodies  >2 publications with IFT172 and Embryonic Tissue
 Pancreas Antibodies  >1 publications with IFT172 and Pancreas
 Intestine Antibodies  >1 publications with IFT172 and Intestine
 Esophagus Antibodies  >1 publications with IFT172 and Esophagus
 Trachea Antibodies  >1 publications with IFT172 and Trachea
 Liver Antibodies  >1 publications with IFT172 and Liver
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