Rabbit Anti-FARS2 Polyclonal Antibody – Cat# MBS6450930

Western Blot analysis of FARS2 expression in transfected 293T cell line by FARS2 MaxPab polyclonal antibody.

Lane 1: FARS2 transfected lysate(52.40 KDa).
Lane 2: Non-transfected lysate.

FARS2 Antibody – Rabbit Polyclonal

Name: FARS2 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6450930
Price: 1165 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6450930

MBS6450930 is an antibody targeting FARS2. Also known as FARS2 (Phenylalanyl-tRNA Synthetase 2, Mitochondrial, FARS1, HSPC320, PheRS, dJ520B18.2) (HRP). Reactive in Human. Host: Rabbit. More details

$1165 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

FARS2, Polyclonal Antibody

Full Product Name

FARS2 (Phenylalanyl-tRNA Synthetase 2, Mitochondrial, FARS1, HSPC320, PheRS, dJ520B18.2) (HRP)

Product Gene Name

anti-FARS2 antibody

Product Synonym Names

Phenylalanyl-tRNA Synthetase 2, mitochondrial; FARS1; HSPC320; PheRS; dJ520B18.2

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).

Purity/Purification

Purified

Specificity

Recognizes human FARS2.

Preparation and Storage

Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates.

Molecular Weight

52,357 Da

OMIM

611592

3D Structure

ModBase 3D Structure for O95363

Immunogen

FARS2 (NP_006558.1, 1aa-451aa) full-length human protein.

Immunogen Sequence

MVGSALRRGAHAYVYLVSKASHISRGHQHQAWGSRPPAAECATQRAPGSVVELLGKSYPQDDHSNLTRKVLTRVGRNLHNQQHHPLWLIKERVKEHFYKQYVGRFGTPLFSVYDNLSPVVTTWQNFDSLLIPADHPSRKKGDNYYLNRTHMLRAHTSAHQWDLLHAGLDAFLVVGDVYRRDQIDSQHYPIFHQLEAVRLFSKHELFAGIKDGESLQLFEQSSRSAHKQETHTMEAVKLVEFDLKQTLTRLMAHLFGDELEIRWVDCYFPFTHPSFEMEINFHGEWLEVLGCGVMEQQLVNSAGAQDRIGWAFGLGLERLAMILYDIPDIRLFWCEDERFLKQFCVSNINQKVKFQPLSKYPAVINDISFWLPSENYAENDFYDLVRTIGGDLVEKVDLIDKFVHPKTHKTSHCYRITYRHMERTLSQREVRHIHQALQEAAVQLLGVEGRF

Conjugate

HRP

Note

Preservative Free

Product Categories/Family for anti-FARS2 antibody

Antibodies; Enzymes; Synthetase

Applications Tested/Suitable for anti-FARS2 antibody

Western Blot (WB)

Application Notes for anti-FARS2 antibody

Applications are based on unconjugated antibody.

Other Notes

Small volumes of anti-FARS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FARS2. It may not necessarily be applicable to this product.

NCBI GI #

5729820

NCBI GeneID

10667

NCBI Accession #

NP_006558.1

UniProt Primary Accession #

O95363

UniProt Secondary Accession #

Q53F66; Q5TCS3; Q6FG29; Q9NPY7; Q9P062; B2R664

UniProt Related Accession #

O95363

GenBank Nucleotide #

NM_006567.3

NCBI Official Full Name

phenylalanine--tRNA ligase, mitochondrial

NCBI Official Synonym Full Names

phenylalanyl-tRNA synthetase 2, mitochondrial

NCBI Official Symbol

FARS2

NCBI Official Synonym Symbols

FARS1; PheRS; COXPD14; HSPC320; dJ520B18.2

UniProt Protein Name

Phenylalanine--tRNA ligase, mitochondrial

UniProt Synonym Protein Names

Phenylalanyl-tRNA synthetase; PheRS

UniProt Gene Name

FARS2

UniProt Synonym Gene Names

FARS1; PheRS

UniProt Entry Name

SYFM_HUMAN

NCBI Protein Information

phenylalanine--tRNA ligase, mitochondrial; dJ236A3.1 (phenylalanine-tRNA synthetase); dJ520B18.2 (FARS1 (phenylalanine-tRNA synthetase)); phenylalanine tRNA ligase 2, mitochondrial; phenylalanine translase; phenylalanine-tRNA synthetase 1 (mitochondrial)

NCBI Summary for FARS2

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. This gene encodes a phenylalanine-tRNA synthetase (PheRS) localized to the mitochondrion which consists of a single polypeptide chain, unlike the (alpha-beta)2 structure of the prokaryotic and eukaryotic cytoplasmic forms of PheRS. Structure analysis and catalytic properties indicate mitochondrial PheRSs may constitute a class of PheRS distinct from the enzymes found in prokaryotes and in the eukaryotic cytoplasm. [provided by RefSeq, Jul 2008]

UniProt Comments for FARS2

FARS2: Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins. Belongs to the class-II aminoacyl-tRNA synthetase family.

Protein type: EC 6.1.1.20; RNA-binding; Translation; Mitochondrial; Ligase

Chromosomal Location of Human Ortholog: 6p25.1

Cellular Component: mitochondrial matrix

Molecular Function: phenylalanine-tRNA ligase activity; magnesium ion binding; ATP binding; tRNA binding

Biological Process: tRNA aminoacylation for protein translation; tRNA processing; phenylalanyl-tRNA aminoacylation; gene expression

Disease: Combined Oxidative Phosphorylation Deficiency 14

Research Articles on FARS2

1. the three FARS2 mutations directly impair aminoacylation function and stability of mtPheRS, leading to a decrease in overall tRNA charging capacity.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FARS2 antibody

Reference Product	PubMed Publications
AARS antibody	>1 publications with FARS2 and AARS

Pathways associated with anti-FARS2 antibody

Products by Pathway	Pathway Diagram
Aminoacyl-tRNA Biosynthesis Pathway antibodies	Aminoacyl-tRNA Biosynthesis Pathway Diagram
Aminoacyl-tRNA Biosynthesis Pathway antibodies	Aminoacyl-tRNA Biosynthesis Pathway Diagram
Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway antibodies	Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway Diagram
Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway antibodies	Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Mitochondrial TRNA Aminoacylation Pathway antibodies	Mitochondrial TRNA Aminoacylation Pathway Diagram
TRNA Aminoacylation Pathway antibodies	TRNA Aminoacylation Pathway Diagram

Diseases associated with anti-FARS2 antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>5 publications with FARS2 and Nervous System Diseases
Memory Disorders Antibodies	>1 publications with FARS2 and Memory Disorders
Cognition Disorders Antibodies	>1 publications with FARS2 and Cognition Disorders

Organs/Tissues associated with anti-FARS2 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>2 publications with FARS2 and Brain
Blood Antibodies	>1 publications with FARS2 and Blood