CIITA Antibody – Rabbit Polyclonal

CIITA: a non-DNA binding transactivator that functions both in constitutive and inducible MHC Class II expression. Defects are a cause of bare lymphocyte syndrome type II (BLS II), a form of severe combined immunodeficiency disease (SCID) characterized by a profound defect in constitutive and interferon-gamma induced MHC II expression, an absence of cellular and humoral T-cell response to antigen challenge, hypogammaglobulinemia and impaired antibody production.

Protein type: EC 2.7.11.1; Transcription, coactivator/corepressor; DNA-binding

Chromosomal Location of Human Ortholog: 16p13

Cellular Component: nucleoplasm; PML body

Molecular Function: protein C-terminus binding; protein binding; transcription activator binding; DNA binding; GTP binding; transcription coactivator activity; protein complex binding; transferase activity, transferring acyl groups; kinase activity; ATP binding

Biological Process: response to antibiotic; transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; positive regulation of transcription, DNA-dependent; positive regulation of MHC class II biosynthetic process; negative regulation of collagen biosynthetic process; positive regulation of MHC class I biosynthetic process; immune response; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; phosphorylation

Disease: Rheumatoid Arthritis; Bare Lymphocyte Syndrome, Type Ii