Rabbit Anti-GRM7 Polyclonal Antibody – Cat# MBS645141

GRM7 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the GRM7 antibody detected the GRM7 protein (arrow).

GRM7 Antibody – Rabbit Polyclonal

Name: GRM7 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS645141
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS645141

L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be… More details

$895 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GRM7, Polyclonal Antibody

Full Product Name

GRM7, NT (GRM7, GPRC1G, MGLUR7, Metabotropic glutamate receptor 7)

Product Gene Name

anti-GRM7 antibody

Product Synonym Names

Anti -GRM7, NT (GRM7, GPRC1G, MGLUR7, Metabotropic glutamate receptor 7)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Human

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

102,251 Da

Chromosome Location

Chromosome: 3; NC_000003.11 (6902802..7783218). Location: 3p26.1-p25.1

OMIM

604101

3D Structure

ModBase 3D Structure for Q14831

Immunogen

GRM7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 239-269 amino acids from the N-terminal region of human GRM7.

Product Categories/Family for anti-GRM7 antibody

Antibodies; Abs to G Protein Receptors

Applications Tested/Suitable for anti-GRM7 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-GRM7 antibody

Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Other Notes

Small volumes of anti-GRM7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GRM7 purchase

MBS645141 is an antibody targeting GRM7. Also known as GRM7, NT (GRM7, GPRC1G, MGLUR7, Metabotropic glutamate receptor 7). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GRM7. It may not necessarily be applicable to this product.

NCBI GI #

223460486

NCBI GeneID

2917

NCBI Accession #

AAI36460.1

UniProt Primary Accession #

Q14831

UniProt Secondary Accession #

Q8NFS2; Q8NFS3; Q8NFS4

UniProt Related Accession #

Q14831

NCBI Official Full Name

GRM7 protein

NCBI Official Synonym Full Names

glutamate receptor, metabotropic 7

NCBI Official Symbol

GRM7

NCBI Official Synonym Symbols

GLUR7; MGLU7; GPRC1G; MGLUR7

UniProt Protein Name

Metabotropic glutamate receptor 7

Protein Family

Metabotropic glutamate receptor

UniProt Gene Name

GRM7

UniProt Synonym Gene Names

GPRC1G; MGLUR7; mGluR7

UniProt Entry Name

GRM7_HUMAN

NCBI Protein Information

metabotropic glutamate receptor 7

UniProt Comments for GRM7

mGluR7: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. Belongs to the G-protein coupled receptor 3 family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 3; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3p26.1-p25.1

Cellular Component: asymmetric synapse; presynaptic membrane; postsynaptic membrane; axon; integral to plasma membrane; dendrite; integral to membrane; presynaptic active zone; plasma membrane; dendritic shaft; cell cortex; receptor complex

Molecular Function: voltage-gated calcium channel activity; group III metabotropic glutamate receptor activity; glutamate binding; calcium channel regulator activity; calcium ion binding; glutamate receptor activity; PDZ domain binding

Biological Process: regulation of synaptic transmission, glutamatergic; behavioral fear response; negative regulation of glutamate secretion; short-term memory; sensory perception of smell; negative regulation of adenylate cyclase activity; regulation of cyclase activity; transmission of nerve impulse; synaptic transmission; negative regulation of cAMP biosynthetic process; sensory perception of sound; adult behavior; conditioned taste aversion; metabotropic glutamate receptor, adenylate cyclase inhibiting pathway

Research Articles on GRM7

1. These results provide preliminary evidence of an association between the GRM7 rs37952452 polymorphism and selective attention deficit and anxiety found within the Korean ADHD population

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GRM7 antibody

Reference Product	PubMed Publications
GRIK1 antibody	>1 publications with GRM7 and GRIK1
GRIP1 antibody	>1 publications with GRM7 and GRIP1
GRM8 antibody	>1 publications with GRM7 and GRM8
GRM4 antibody	>1 publications with GRM7 and GRM4
GRM1 antibody	>1 publications with GRM7 and GRM1

Pathways associated with anti-GRM7 antibody

Products by Pathway	Pathway Diagram
Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway antibodies	Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
GPCRs, Class C Metabotropic Glutamate, Pheromone Pathway antibodies	GPCRs, Class C Metabotropic Glutamate, Pheromone Pathway Diagram
Glutamatergic Synapse Pathway antibodies	Glutamatergic Synapse Pathway Diagram
Glutamatergic Synapse Pathway antibodies	Glutamatergic Synapse Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram

Diseases associated with anti-GRM7 antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>6 publications with GRM7 and Nervous System Diseases
Anxiety Disorders Antibodies	>4 publications with GRM7 and Anxiety Disorders
Attention Deficit Disorder with Hyperactivity Antibodies	>4 publications with GRM7 and Attention Deficit Disorder with Hyperactivity
Depressive Disorder Antibodies	>3 publications with GRM7 and Depressive Disorder
Central Nervous System Diseases Antibodies	>2 publications with GRM7 and Central Nervous System Diseases
Substance-Related Disorders Antibodies	>2 publications with GRM7 and Substance-Related Disorders
Brain Diseases Antibodies	>1 publications with GRM7 and Brain Diseases
Nerve Degeneration Antibodies	>1 publications with GRM7 and Nerve Degeneration
Developmental Disabilities Antibodies	>1 publications with GRM7 and Developmental Disabilities
Necrosis Antibodies	>1 publications with GRM7 and Necrosis

Organs/Tissues associated with anti-GRM7 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>8 publications with GRM7 and Brain