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CTNNA2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS645161

May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during… More details

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Product Overview

Online Datasheet in PDF
Product Name
CTNNA2, Polyclonal Antibody
Full Product Name
CTNNA2 (Catenin alpha-2, Alpha N-catenin, Alpha-catenin-related Protein, CAPR)
Product Gene Name
anti-CTNNA2 antibody
Product Synonym Names
Anti -CTNNA2 (Catenin alpha-2, Alpha N-catenin, Alpha-catenin-related Protein, CAPR)
Immunogen Sequence
MTSATSPIIL KWDPKSLEIR TLTVERLLEP LVTQVTTLVN TSNKGPSGKK KGRSKKAHVL AASVEQATQN FLEKGEQIAK ESQDLKEELV AAVEDVRKQG ETMRIASSEF ADDPCSSVKR GTMVRAARAL LSAVTRLLIL ADMADVMRLL SHLKIVEEAL EAVKNATNEQ DLANRFKEFG KEMVKLNYVA ARRQQELKDP HCRDEMAAAR GALKKNATML YTASQAFLRH PDVAATRANR DYVFKQVQEA IAGISNAAQA TSPTDEAKGH TGIGELAAAL NEFDNKIILD PMTFSEARFR PSLEERLESI ISGAALMADS SCTRDDRRER IVAECNAVRQ ALQDLLSEYM NNTGRKEKGD PLNIAIDKMT KKTRDLRRQL RKAVMDHISD SFLETNVPLL VLIEAAKSGN EKEVKEYAQV FREHANKLVE VANLACSISN NEEGVKLVRM AATQIDSLCP QVINAALTLA ARPQSKVAQD NMDVFKDQWE KQVRVLTEAV DDITSVDDFL SVSENHILED VNKCVIALQE GDVDTLDRTA GAIRGRAARV IHIINAEMEN YEAGVYTEKV LEATKLLSET VMPRFAEQVE VAIEALSANV PQPFEENEFI DASRLVYDGV RDIRKAVLMI RTPEELEDDS DFEQEDYDVR SRTSVQTEDD QLIAGQSARA IMAQLPQEEK AKIAEQVEIF HQEKSKLDAE VAKWDDSGND IIVLAKQMCM IMMEMTDFTR GKGPLKNTSD VINAAKKIAE AGSRMDKLAR AVADQCPDSA CKQDLLAYLQ RIALYCHQLN ICSKVKAEVQ NLGGELIVSG LDSATSLIQA AKNLMNAVVL TVKASYVAST KYQKVYGTAA VNSPVVSWKM KAPEKKPLVK REKPEEFQTR VRRGSQKKHI SPVQALSEFK AMDSF
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human CTNNA2.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
105,313 Da
Chromosome Location
Chromosome: 2; NC_000002.11 (79740060..80875993). Location: 2p12-p11.1
OMIM
114025
3D Structure
ModBase 3D Structure for P26232
Immunogen
Full length human CTNNA2, aa1-905 (NP_004380.2).

Product Categories/Family for anti-CTNNA2 antibody

Antibodies; Abs to Catenin
Applications Tested/Suitable for anti-CTNNA2 antibody
Western Blot (WB)
Application Notes for anti-CTNNA2 antibody
Suitable for use in Western Blot.

Western Blot (WB) of anti-CTNNA2 antibody

Western Blot analysis of CTNNA2 expression in transfected 293T cell line by CTNNA2 polyclonal antibody. Lane 1: CTNNA2 transfected lysate (100.4kD). Lane 2: Non-transfected lysate.
Rabbit Anti-CTNNA2 Polyclonal Antibody – Cat# MBS645161

Other Notes

Small volumes of anti-CTNNA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CTNNA2 purchase

MBS645161 is an antibody targeting CTNNA2. Also known as CTNNA2 (Catenin alpha-2, Alpha N-catenin, Alpha-catenin-related Protein, CAPR). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CTNNA2. It may not necessarily be applicable to this product.

NCBI GI #
543583735
NCBI GeneID
1496
NCBI Accession #
NP_001269529.1
UniProt Primary Accession #
P26232
UniProt Secondary Accession #
Q4ZFW1; Q53R26; Q53R33; Q53T67; Q53T71; Q53TM8; Q7Z3L1; B3KXE5; B7Z2W7; B7Z352; B7Z898
UniProt Related Accession #
P26232
GenBank Nucleotide #
NM_001282600.1
NCBI Official Full Name
catenin alpha-2 isoform 6
NCBI Official Synonym Full Names
catenin (cadherin-associated protein), alpha 2
NCBI Official Symbol
CTNNA2
NCBI Official Synonym Symbols
CAPR; CTNR; CAP-R; CT114
UniProt Protein Name
Catenin alpha-2
UniProt Synonym Protein Names
Alpha N-catenin; Alpha-catenin-related protein
Protein Family
Catenin
UniProt Gene Name
CTNNA2
UniProt Synonym Gene Names
CAPR
UniProt Entry Name
CTNA2_HUMAN
NCBI Protein Information
catenin alpha-2; alpha N-catenin; alpha-N-catenin; cancer/testis antigen 114; alpha-catenin-related protein; cadherin-associated protein, related

UniProt Comments for CTNNA2

CTNNA2: May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation. Interacts with ZNF639. Belongs to the vinculin/alpha-catenin family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Cancer Testis Antigen (CTA); Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2p12-p11.1

Cellular Component: adherens junction; cell-cell adherens junction; basolateral plasma membrane; axon; lamellipodium; cytoplasm; cytosol; actin cytoskeleton

Molecular Function: actin filament binding; protein binding; structural constituent of cytoskeleton; cadherin binding

Biological Process: cell-cell adhesion; muscle cell differentiation; prepulse inhibition; axonogenesis; radial glia guided migration of Purkinje cell; dendrite morphogenesis; brain morphogenesis; positive regulation of muscle cell differentiation; regulation of synapse structural plasticity
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Research Articles on CTNNA2

1. Common variants in CTNNA2 are associated with excitement-seeking and risk-taking.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CTNNA2 antibody

 Products by Pathway  Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 CDO In Myogenesis Pathway antibodies  CDO In Myogenesis Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Endometrial Cancer Pathway antibodies  Endometrial Cancer Pathway Diagram

Diseases associated with anti-CTNNA2 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >5 publications with CTNNA2 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >2 publications with CTNNA2 and Cardiovascular Diseases
 Abnormalities, Multiple Antibodies  >1 publications with CTNNA2 and Abnormalities, Multiple
 Stroke Antibodies  >1 publications with CTNNA2 and Stroke
 Neoplasms Antibodies  >1 publications with CTNNA2 and Neoplasms

Organs/Tissues associated with anti-CTNNA2 antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >17 publications with CTNNA2 and Nerve
 Brain Antibodies  >12 publications with CTNNA2 and Brain
 Embryonic Tissue Antibodies  >3 publications with CTNNA2 and Embryonic Tissue
 Muscle Antibodies  >2 publications with CTNNA2 and Muscle
 Eye Antibodies  >2 publications with CTNNA2 and Eye
 Testis Antibodies  >1 publications with CTNNA2 and Testis
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