Rabbit Anti-TUFM Polyclonal Antibody – Cat# MBS645162

Western blot analysis of TUFM (arrow) using rabbit polyclonal TUFM Antibody (C-term) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the TUFM gene.

TUFM Antibody – Rabbit Polyclonal

Name: TUFM Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS645162
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS645162

This gene encodes a protein which participates in protein translation in mitochondria. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency resulting in lactic acidosis and fatal encephalopathy. A pseudogene has been… More details

$895 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TUFM, Polyclonal Antibody

Full Product Name

TUFM, CT (TUFM, Elongation factor Tu, mitochondrial, P43)

Product Gene Name

anti-Tufm antibody

Product Synonym Names

Anti -TUFM, CT (TUFM, Elongation factor Tu, mitochondrial, P43)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Human

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

49,508 Da

Chromosome Location

Chromosome: 7; NC_000073.6 (126487355..126490731). Location: 7 F3; 7

3D Structure

ModBase 3D Structure for Q8BFR5

Immunogen

TUFM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 341-370 amino acids from the C-terminal region of human TUFM.

Product Categories/Family for anti-Tufm antibody

Antibodies; Abs to Mitochondrial Proteins

Applications Tested/Suitable for anti-Tufm antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-Tufm antibody

Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Other Notes

Small volumes of anti-Tufm antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Tufm purchase

MBS645162 is an antibody targeting Tufm. Also known as TUFM, CT (TUFM, Elongation factor Tu, mitochondrial, P43). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Tufm. It may not necessarily be applicable to this product.

NCBI GI #

38173913

NCBI GeneID

233870

NCBI Accession #

AAH60959.1

UniProt Primary Accession #

Q8BFR5

UniProt Secondary Accession #

Q497E7; Q6P919

UniProt Related Accession #

Q8BFR5

NCBI Official Full Name

Tufm protein

NCBI Official Synonym Full Names

Tu translation elongation factor, mitochondrial

NCBI Official Symbol

Tufm

NCBI Official Synonym Symbols

EFTU; C76308; C76389; EF-TuMT; 2300002G02Rik

UniProt Protein Name

Elongation factor Tu, mitochondrial

UniProt Gene Name

Tufm

UniProt Entry Name

EFTU_MOUSE

NCBI Protein Information

elongation factor Tu, mitochondrial

UniProt Comments for Tufm

EFTU: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Defects in TUFM are the cause of combined oxidative phosphorylation deficiency type 4 (COXPD4). COXPD4 is characterized by neonatal lactic acidosis, rapidly progressive encephalopathy, severely decreased mitochondrial protein synthesis, and combined deficiency of mtDNA-related mitochondrial respiratory chain complexes. Belongs to the GTP-binding elongation factor family. EF-Tu/EF-1A subfamily.

Protein type: Mitochondrial; RNA-binding; Translation elongation; Translation

Cellular Component: membrane; mitochondrion; mitochondrial inner membrane; intracellular; myelin sheath

Molecular Function: GTPase activity; GTP binding; nucleotide binding; translation elongation factor activity

Biological Process: translational elongation; translation

Research Articles on Tufm

1. By recruiting Atg5-Atg12 and NLRX1, TUFM serves as a nodal checkpoint of the RIG-I-MAVS axis. It acts similarly to NLRX1 by inhibiting RigI-like-receptor-induced IFN-I but promoting autophagy.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-Tufm antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>14 publications with Tufm and Neoplasms
Nervous System Diseases Antibodies	>4 publications with Tufm and Nervous System Diseases
Brain Diseases Antibodies	>3 publications with Tufm and Brain Diseases
Inflammation Antibodies	>3 publications with Tufm and Inflammation
Liver Neoplasms Antibodies	>2 publications with Tufm and Liver Neoplasms
Musculoskeletal Diseases Antibodies	>2 publications with Tufm and Musculoskeletal Diseases
Liver Diseases Antibodies	>1 publications with Tufm and Liver Diseases
Necrosis Antibodies	>1 publications with Tufm and Necrosis

Organs/Tissues associated with anti-Tufm antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>8 publications with Tufm and Blood
Brain Antibodies	>5 publications with Tufm and Brain
Liver Antibodies	>4 publications with Tufm and Liver
Spleen Antibodies	>2 publications with Tufm and Spleen
Eye Antibodies	>2 publications with Tufm and Eye
Lung Antibodies	>2 publications with Tufm and Lung
Stomach Antibodies	>1 publications with Tufm and Stomach
Kidney Antibodies	>1 publications with Tufm and Kidney
Pancreas Antibodies	>1 publications with Tufm and Pancreas
Skin Antibodies	>1 publications with Tufm and Skin