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NFS1 Antibody – Mouse Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS645175

Iron-sulfur clusters are required for the function of many cellular enzymes. The proteins encoded by this gene supply inorganic sulfur to these clusters by removing the sulfur from cysteine, creating alanine in the process. This gene uses alternate in-frame… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
NFS1, Polyclonal Antibody
Full Product Name
NFS1 (NIFS, Cysteine Desulfurase, Mitochondrial, HUSSY-08)
Product Gene Name
anti-NFS1 antibody
Product Synonym Names
Anti -NFS1 (NIFS, Cysteine Desulfurase, Mitochondrial, HUSSY-08)
Immunogen Sequence
MLLRAAWRRA AVAVTAAPGP KPAAPTRGLR LRVGDRAPQS AVPADTAAAP EVGPVLRPLY MDVQATTPLD PRVLDAMLPY LINYYGNPHS RTHAYGWESE AAMERARQQV ASLIGADPRE IIFTSGATES NNIAIKGVAR FYRSRKKHLI TTQTEHKCVL DSCRSLEAEG FQVTYLPVQK SGIIDLKELE AAIQPDTSLV SVMTVNNEIG VKQPIAEIGR ICSSRKVYFH TDAAQAVGKI PLDVNDMKID LMSISGHKIY GPKGVGAIYI RRRPRVRVEA LQSGGGQERG MRSGTVPTPL VVGLGAACEV AQQEMEYDHK RISKLSERLI QNIMKSLPDV VMNGDPKHHY PGCINLSFAY VEGESLLMAL KDVALSSGSA CTSASLEPSY VLRAIGTDED LAHSSIRFGI GRFTTEEEVD YTVEKCIQHV KRLREMSPLW EMVQDGIDLK SIKWTQH
Clonality
Polyclonal
Isotype
IgG
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human NFS1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
50,196 Da
Chromosome Location
Chromosome: 20; NC_000020.10 (34256610..34287287, complement). Location: 20q11.22
OMIM
603485
3D Structure
ModBase 3D Structure for Q9Y697
Immunogen
Full length human NFS1, aa1-457 (NP_066923.3).

Product Categories/Family for anti-NFS1 antibody

Antibodies; Abs to Mitochondrial Proteins
Applications Tested/Suitable for anti-NFS1 antibody
Western Blot (WB)
Application Notes for anti-NFS1 antibody
Suitable for use in Western Blot.

Western Blot (WB) of anti-NFS1 antibody

Western Blot analysis of NFS1 expression in transfected 293T cell line by NFS1 polyclonal antibody. Lane1:NFS1 transfected lysate (50.27kD). Lane2:Non-transfected lysate.
Mouse Anti-NFS1 Polyclonal Antibody – Cat# MBS645175

Other Notes

Small volumes of anti-NFS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NFS1 purchase

MBS645175 is an antibody targeting NFS1. Also known as NFS1 (NIFS, Cysteine Desulfurase, Mitochondrial, HUSSY-08). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for NFS1. It may not necessarily be applicable to this product.

NCBI GI #
119596578
NCBI GeneID
9054
NCBI Accession #
EAW76172.1
UniProt Primary Accession #
Q9Y697
UniProt Secondary Accession #
Q6P0L8; Q9NTZ5; Q9Y481; B3KMA5; B4DXK9; E1P5R8; F5GYK5
UniProt Related Accession #
Q9Y697
NCBI Official Full Name
NFS1 nitrogen fixation 1 (S. cerevisiae), isoform CRA_a
NCBI Official Synonym Full Names
NFS1 cysteine desulfurase
NCBI Official Symbol
NFS1
NCBI Official Synonym Symbols
IscS; NIFS; HUSSY-08
UniProt Protein Name
Cysteine desulfurase, mitochondrial
Protein Family
Cysteine desulfurase
UniProt Gene Name
NFS1
UniProt Synonym Gene Names
NIFS
UniProt Entry Name
NFS1_HUMAN
NCBI Protein Information
cysteine desulfurase, mitochondrial; NFS1 nitrogen fixation 1 homolog; nitrogen-fixing bacteria S-like protein; nitrogen fixation 1 (S. cerevisiae, homolog)

UniProt Comments for NFS1

NFS1: Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron- sulfur (Fe-S) clusters. May be involved in the biosynthesis of molybdenum cofactor. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. 2 isoforms of the human protein are produced by alternative initiation.

Protein type: Mitochondrial; Cofactor and Vitamin Metabolism - thiamine; EC 2.8.1.7; Transferase

Chromosomal Location of Human Ortholog: 20q11.22

Cellular Component: nucleoplasm; intracellular membrane-bound organelle; mitochondrion; mitochondrial matrix; cytoplasm; nucleolus; nucleus; cytosol

Molecular Function: protein binding; protein homodimerization activity; cysteine desulfurase activity; pyridoxal phosphate binding

Biological Process: cysteine metabolic process; iron incorporation into metallo-sulfur cluster; vitamin metabolic process; sulfur amino acid metabolic process; protein complex assembly; Mo-molybdopterin cofactor biosynthetic process; molybdopterin cofactor biosynthetic process; water-soluble vitamin metabolic process
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Research Articles on NFS1

1. Nfs1, the cysteine desulfurase responsible for providing sulfur for cluster formation, is required for the increased Isu stability occurring after disruption of cluster formation on or transfer from Isu

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NFS1 antibody

 Reference Product  PubMed Publications
 ISCU antibody  >11 publications with NFS1 and ISCU
 FXN antibody  >6 publications with NFS1 and FXN
 MOCS3 antibody  >2 publications with NFS1 and MOCS3
 HSCB antibody  >1 publications with NFS1 and HSCB

Pathways associated with anti-NFS1 antibody

 Products by Pathway  Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Vitamins And Cofactors Pathway antibodies  Metabolism Of Vitamins And Cofactors Pathway Diagram
 Metabolism Of Water-soluble Vitamins And Cofactors Pathway antibodies  Metabolism Of Water-soluble Vitamins And Cofactors Pathway Diagram
 Mitochondrial Iron-Sulfur Cluster Biogenesis Pathway antibodies  Mitochondrial Iron-Sulfur Cluster Biogenesis Pathway Diagram
 Molybdenum Cofactor Biosynthesis Pathway antibodies  Molybdenum Cofactor Biosynthesis Pathway Diagram
 Sulfur Relay System Pathway antibodies  Sulfur Relay System Pathway Diagram
 Sulfur Relay System Pathway antibodies  Sulfur Relay System Pathway Diagram
 Thiamine Metabolism Pathway antibodies  Thiamine Metabolism Pathway Diagram
 Thiamine Metabolism Pathway antibodies  Thiamine Metabolism Pathway Diagram
 Alanine Biosynthesis III Pathway antibodies  Alanine Biosynthesis III Pathway Diagram

Organs/Tissues associated with anti-NFS1 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >4 publications with NFS1 and Liver
 Muscle Antibodies  >3 publications with NFS1 and Muscle
 Heart Antibodies  >2 publications with NFS1 and Heart
 Spleen Antibodies  >1 publications with NFS1 and Spleen
 Blood Antibodies  >1 publications with NFS1 and Blood
 Kidney Antibodies  >1 publications with NFS1 and Kidney
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