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TRAPPC2 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS645224

Prevents transcriptional repression and induction of cell death by ENO1. May play a role in vesicular transport from endoplasmic reticulum to Golgi. More details

$880 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TRAPPC2, Monoclonal Antibody
Full Product Name
TRAPPC2 (Trafficking Protein Particle Complex Subunit 2, Sedlin, SEDL)
Product Gene Name
anti-TRAPPC2 antibody
Product Synonym Names
Anti -TRAPPC2 (Trafficking Protein Particle Complex Subunit 2, Sedlin, SEDL)
Immunogen Sequence
MSGSFYFVIV GHHDNPVFEM EFLPAGKAES KDDHRHLNQF IAHAALDLVD ENMWLSNNMY LKTVDKFNEW FVSAFVTAGH MRFIMLHDIR QEDGIKNFFT DVYDLYIKFS MNPFYEPNSP IRSSAFDRKV QFLGKKHLLS *
Clonality
Monoclonal
Isotype
IgG2b,k
Clone Number
2E10
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human TRAPPC2.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
16,445 Da
Chromosome Location
Chromosome: X; NC_000023.10 (13730361..13752754, complement). Location: Xp22
OMIM
300202
3D Structure
ModBase 3D Structure for P0DI81
Immunogen
Full length recombinant corresponding to aa1-141 from human TRAPPC2 (AAH16915) with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-TRAPPC2 antibody

Antibodies; Abs to Transcription Factors
Applications Tested/Suitable for anti-TRAPPC2 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-TRAPPC2 antibody
Suitable for use in ELISA and Western Blot.

Western Blot (WB) of anti-TRAPPC2 antibody

Western Blot detection against Immunogen (41.51kD).
Mouse Anti-TRAPPC2 Monoclonal Antibody – Cat# MBS645224

Western Blot (WB) of anti-TRAPPC2 antibody

TRAPPC2 monoclonal antibody, Western Blot analysis of TRAPPC2 expression in Hela.
Mouse Anti-TRAPPC2 Monoclonal Antibody, Western Blot (WB) – Cat# MBS645224

Testing Data of anti-TRAPPC2 antibody

Detection limit for recombinant GST tagged TRAPPC2 is ~0.3ng/ml as a capture antibody.
Mouse Anti-TRAPPC2 Monoclonal Antibody, Testing Data – Cat# MBS645224

Other Notes

Small volumes of anti-TRAPPC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TRAPPC2 purchase

MBS645224 is an antibody targeting TRAPPC2. Also known as TRAPPC2 (Trafficking Protein Particle Complex Subunit 2, Sedlin, SEDL). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for TRAPPC2. It may not necessarily be applicable to this product.

NCBI GI #
291045294
NCBI GeneID
6399
NCBI Accession #
NP_001122307.2
UniProt Primary Accession #
P0DI81
UniProt Secondary Accession #
O14582; Q9HD16; A6NEG0
UniProt Related Accession #
P0DI81
GenBank Nucleotide #
NM_001128835.2
NCBI Official Full Name
trafficking protein particle complex subunit 2 isoform 2
NCBI Official Synonym Full Names
trafficking protein particle complex 2
NCBI Official Symbol
TRAPPC2
NCBI Official Synonym Symbols
SEDL; SEDT; MIP2A; TRS20; ZNF547L; hYP38334; TRAPPC2P1
UniProt Protein Name
Trafficking protein particle complex subunit 2
UniProt Synonym Protein Names
Sedlin
Protein Family
Trafficking protein particle complex
UniProt Gene Name
TRAPPC2
UniProt Synonym Gene Names
SEDL
UniProt Entry Name
TPC2A_HUMAN
NCBI Protein Information
trafficking protein particle complex subunit 2; sedlin

NCBI Summary for TRAPPC2

The protein encoded by this gene is thought to be part of a large multi-subunit complex involved in the targeting and fusion of endoplasmic reticulum-to-Golgi transport vesicles with their acceptor compartment. In addition, the encoded protein can bind c-myc promoter-binding protein 1 and block its transcriptional repression capability. Mutations in this gene are a cause of spondyloepiphyseal dysplasia tarda (SEDT). A processed pseudogene of this gene is located on chromosome 19, and other pseudogenes are found on chromosomes 8 and Y. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2010]
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UniProt Comments for TRAPPC2

TRAPPC2: Prevents MBP1-mediated transcriptional repression and antagonizes MBP1-mediated cell death. May play a role in vesicular transport from endoplasmic reticulum to Golgi. Belongs to the TRAPP small subunits family. Sedlin subfamily. Part of the multisubunit TRAPP (transport protein particle) complex. Interacts with MBP1 and TRAPPC2L. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: Xp22

Cellular Component: Golgi apparatus; perinuclear region of cytoplasm; endoplasmic reticulum; nucleus

Molecular Function: protein binding; transcription factor binding

Biological Process: ER to Golgi vesicle-mediated transport; transcription, DNA-dependent; regulation of transcription, DNA-dependent; skeletal development

Disease: Spondyloepiphyseal Dysplasia Tarda, X-linked
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Research Articles on TRAPPC2

1. Sedlin bound and promoted efficient cycling of Sar1, a guanosine triphosphatase that can constrict membranes, and thus allowed nascent carriers to grow and incorporate procollagen prefibrils.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-TRAPPC2 antibody

 Disease Name  Pubmed Publications
 Spondyloepiphyseal Dysplasia Tarda, X-Linked Antibodies  >37 publications with TRAPPC2 and Spondyloepiphyseal Dysplasia Tarda, X-Linked
 Neurobehavioral Manifestations Antibodies  >1 publications with TRAPPC2 and Neurobehavioral Manifestations
 Congenital Abnormalities Antibodies  >1 publications with TRAPPC2 and Congenital Abnormalities
 Kidney Diseases Antibodies  >1 publications with TRAPPC2 and Kidney Diseases
 Neoplasms Antibodies  >1 publications with TRAPPC2 and Neoplasms
 Liver Diseases Antibodies  >1 publications with TRAPPC2 and Liver Diseases
 Necrosis Antibodies  >1 publications with TRAPPC2 and Necrosis
 Uterine Cervical Neoplasms Antibodies  >1 publications with TRAPPC2 and Uterine Cervical Neoplasms

Organs/Tissues associated with anti-TRAPPC2 antibody

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >1 publications with TRAPPC2 and Embryonic Tissue
 Lung Antibodies  >1 publications with TRAPPC2 and Lung
 Heart Antibodies  >1 publications with TRAPPC2 and Heart
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