Rabbit Anti-MCHR1 Polyclonal Antibody – Cat# MBS645282

Human Brain, Substantia Nigra (formalin-fixed, paraffin-embedded) stained with MCHR1 antibody at 10-18ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.

Melanin Concentrating Hormone Receptor 1 (MCHR1) Antibody – Rabbit Polyclonal

Name: MCHR1 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS645282
Price: 910 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS645282

MCHR1 is a Melanin-Concentrating Hormone Receptor that binds MCH to regulate nutritional homeostasis, including feeding and body adiposity. The receptor also functions in sensory perception and integration of smell and gustatory inputs, as well as in emotion… More details

$910 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Melanin Concentrating Hormone Receptor 1 (MCHR1), Polyclonal Antibody

Full Product Name

Melanin Concentrating Hormone Receptor 1, CT (MCH Receptor 1, MCHR1, MCH-R1, MCHR-1, MCH1R, MCH-1R, MCHR, G-Protein Coupled Receptor 24, GPR24, GPCR MCH1, GPCR SLC/MCH1, MGC32129, Somatostatin Receptor-like Protein, SLC1, SLC-1)

Product Gene Name

anti-MCHR1 antibody

Product Synonym Names

Anti -Melanin Concentrating Hormone Receptor 1, CT (MCH Receptor 1, MCHR1, MCH-R1, MCHR-1, MCH1R, MCH-1R, MCHR, G-Protein Coupled Receptor 24, GPR24, GPCR MCH1, GPCR SLC/MCH1, MGC32129, Somatostatin Receptor-like Protein, SLC1, SLC-1)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, 0.1% sodium azide.

Purity/Purification

Affinity Purified
Purified by immunoaffinity chromatography.

Specificity

Recognizes human MCHR1. Species sequence homology: Mouse and rat (94%).

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

45,963 Da

Chromosome Location

Chromosome: 22; NC_000022.10 (41075182..41078818). Location: 22q13.2

OMIM

601751

3D Structure

ModBase 3D Structure for Q99705

Immunogen

Synthetic peptide corresponding to human MCHR1 at C-terminal (KLH).

Product Categories/Family for anti-MCHR1 antibody

Antibodies; Abs to G Protein Receptors

Applications Tested/Suitable for anti-MCHR1 antibody

Immunohistochemistry (IHC)

Application Notes for anti-MCHR1 antibody

Suitable for use in Immunohistochemistry.
Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 10-18ug/ml

Other Notes

Small volumes of anti-MCHR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MCHR1 purchase

MBS645282 is an antibody targeting MCHR1. Also known as Melanin Concentrating Hormone Receptor 1, CT (MCH Receptor 1, MCHR1, MCH-R1, MCHR-1, MCH1R, MCH-1R, MCHR, G-Protein Coupled Receptor 24, GPR24, GPCR MCH1, GPCR SLC/MCH1, MGC32129, Somatostatin Receptor-like Protein, SLC1, SLC-1). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MCHR1. It may not necessarily be applicable to this product.

NCBI GI #

88758590

NCBI GeneID

2847

NCBI Accession #

NP_005288.3

UniProt Primary Accession #

Q99705

UniProt Secondary Accession #

Q5R3J1; Q96S47; Q9BV08; B2RBX6

UniProt Related Accession #

Q99705

GenBank Nucleotide #

NM_005297.3

NCBI Official Full Name

melanin-concentrating hormone receptor 1

NCBI Official Synonym Full Names

melanin-concentrating hormone receptor 1

NCBI Official Symbol

MCHR1

NCBI Official Synonym Symbols

SLC1; GPR24; MCH1R; SLC-1; MCH-1R

UniProt Protein Name

Melanin-concentrating hormone receptor 1

UniProt Synonym Protein Names

G-protein coupled receptor 24; MCH-1R; MCH1R; MCHR; SLC-1; Somatostatin receptor-like protein

Protein Family

Melanin-concentrating hormone receptor

UniProt Gene Name

MCHR1

UniProt Synonym Gene Names

GPR24; SLC1; MCH receptor 1; MCH-R1; MCHR-1; MCH1R; MCHR

UniProt Entry Name

MCHR1_HUMAN

NCBI Protein Information

melanin-concentrating hormone receptor 1; MCH receptor 1; G protein-coupled receptor 24; somatostatin receptor-like protein

NCBI Summary for MCHR1

The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin. [provided by RefSeq, Jul 2008]

UniProt Comments for MCHR1

MCHR1: Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1

Chromosomal Location of Human Ortholog: 22q13.2

Cellular Component: integral to plasma membrane; nonmotile primary cilium; plasma membrane

Molecular Function: protein C-terminus binding; G-protein coupled receptor activity; neuropeptide receptor activity; hormone binding; melanin-concentrating hormone receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; generation of precursor metabolites and energy; neuropeptide signaling pathway; feeding behavior; G-protein signaling, adenylate cyclase inhibiting pathway; positive regulation of calcium ion transport

Research Articles on MCHR1

1. results suggest that MCHR1 may influence schizophrenia susceptibility, in particular among men and patients responding to conventional (nonclozapine) treatment

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MCHR1 antibody

Reference Product	PubMed Publications
POMC antibody	>6 publications with MCHR1 and POMC
SST antibody	>2 publications with MCHR1 and SST
NPY antibody	>2 publications with MCHR1 and NPY

Pathways associated with anti-MCHR1 antibody

Products by Pathway	Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram
G Alpha (q) Signalling Events Pathway antibodies	G Alpha (q) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
GPCRs, Class A Rhodopsin-like Pathway antibodies	GPCRs, Class A Rhodopsin-like Pathway Diagram
Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies	Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Peptide Ligand-binding Receptors Pathway antibodies	Peptide Ligand-binding Receptors Pathway Diagram

Diseases associated with anti-MCHR1 antibody

Disease Name	Pubmed Publications
Weight Loss Antibodies	>21 publications with MCHR1 and Weight Loss
Disease Models, Animal Antibodies	>9 publications with MCHR1 and Disease Models, Animal
Brain Diseases Antibodies	>9 publications with MCHR1 and Brain Diseases
Nervous System Diseases Antibodies	>7 publications with MCHR1 and Nervous System Diseases
Mood Disorders Antibodies	>7 publications with MCHR1 and Mood Disorders
Inflammation Antibodies	>3 publications with MCHR1 and Inflammation
Learning Disorders Antibodies	>3 publications with MCHR1 and Learning Disorders
Liver Diseases Antibodies	>2 publications with MCHR1 and Liver Diseases
Neoplasms Antibodies	>2 publications with MCHR1 and Neoplasms
Congenital Abnormalities Antibodies	>1 publications with MCHR1 and Congenital Abnormalities

Organs/Tissues associated with anti-MCHR1 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>76 publications with MCHR1 and Brain
Liver Antibodies	>10 publications with MCHR1 and Liver
Kidney Antibodies	>7 publications with MCHR1 and Kidney
Testis Antibodies	>1 publications with MCHR1 and Testis
Pancreas Antibodies	>1 publications with MCHR1 and Pancreas
Uncharacterized Tissue Antibodies	>1 publications with MCHR1 and Uncharacterized Tissue