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TOB2 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS645299

TOB2 is a 344aa rich novel member of the Tob:BTG1 anti-proliferative family of proteins characterized by similarities in their N-terminal BTG:Tob homology domains. This anti-proliferative protein inhibits cell cycle progression from the G0:G1 to S phases and… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TOB2, Monoclonal Antibody
Full Product Name
TOB2 (Protein Tob2, Transducer of erbB-2 2, Protein Tob4, KIAA1663, TOB4, TOBL, TROB2)
Product Gene Name
anti-TOB2 antibody
Product Synonym Names
Anti -TOB2 (Protein Tob2, Transducer of erbB-2 2, Protein Tob4, KIAA1663, TOB4, TOBL, TROB2)
Immunogen Sequence
MQLEIKVALN FIISYLYNKL PRRRADLFGE ELERLLKKKY EGHWYPEKPL KGSGFRCVHI GEMVDPVVEL AAKRSGLAVE DVRANVPEEL SVWIDPFEVS YQIGEKGAVK VLYLDDSEGC GAPELDKEIK SSFNPDAQVF VPIGSQDSSL SNSPSPSFGQ SPSPTFIPRS AQPITFTTAS FAATKFGSTK MKKGGGAASG GGVASSGAGG QQPPQQPRMA RSPTNSLLKH KSLSLSMHSL NFITANPAPQ SQLSPNAKEF VYNGGGSPSL FFDAADGQGS GTPGPFGGSG AGTCNSSSFD MAQVFGGGAN SLFLEKTPFV EGLSYNLNTM QYPSQQFQPV VLAN
Clonality
Monoclonal
Isotype
IgG2b,k
Clone Number
2F2-1A7
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human TOB2.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
36,632 Da
Chromosome Location
Chromosome: 22; NC_000022.10 (41829492..41844234, complement). Location: 22q13.2
OMIM
607396
3D Structure
ModBase 3D Structure for Q14106
Immunogen
Full length recombinant corresponding to aa1-344 from human TOB2 (AAH38957) with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-TOB2 antibody

Antibodies; Abs to Oncoproteins
Applications Tested/Suitable for anti-TOB2 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-TOB2 antibody
Suitable for use in ELISA and Western Blot.

Western Blot (WB) of anti-TOB2 antibody

Western Blot detection against Immunogen (63.95kD).
Mouse Anti-TOB2 Monoclonal Antibody – Cat# MBS645299

Western Blot (WB) of anti-TOB2 antibody

Western Blot analysis of TOB2 expression in transfected 293T cell line by TOB2 monoclonal antibody |Lane 1: TOB2 transfected lysate (36.6kD).|Lane 2: Non-transfected lysate.
Mouse Anti-TOB2 Monoclonal Antibody, Western Blot (WB) – Cat# MBS645299

Testing Data of anti-TOB2 antibody

Detection limit for recombinant GST tagged TOB2 is 0.3ng/ml as a capture antibody.
Mouse Anti-TOB2 Monoclonal Antibody, Testing Data – Cat# MBS645299

Other Notes

Small volumes of anti-TOB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TOB2 purchase

MBS645299 is an antibody targeting TOB2. Also known as TOB2 (Protein Tob2, Transducer of erbB-2 2, Protein Tob4, KIAA1663, TOB4, TOBL, TROB2). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for TOB2. It may not necessarily be applicable to this product.

NCBI GI #
47678719
NCBI GeneID
10766
NCBI Accession #
CAG30480.1
UniProt Primary Accession #
Q14106
UniProt Secondary Accession #
Q6FHR7; Q9BY97; Q9UBI0
UniProt Related Accession #
Q14106
NCBI Official Full Name
TOB2
NCBI Official Synonym Full Names
transducer of ERBB2, 2
NCBI Official Symbol
TOB2
NCBI Official Synonym Symbols
TOB4; TOBL; TROB2
UniProt Protein Name
Protein Tob2
UniProt Synonym Protein Names
Protein Tob4; Transducer of erbB-2 2
Protein Family
Protein
UniProt Gene Name
TOB2
UniProt Synonym Gene Names
KIAA1663; TOB4; TROB2
UniProt Entry Name
TOB2_HUMAN
NCBI Protein Information
protein Tob2; protein Tob4; transducer of erbB-2 2

NCBI Summary for TOB2

TOB2 belongs to the TOB (see TOB1; MIM 605523)/BTG1 (MIM 109580) family of antiproliferative proteins, which are involved in the regulation of cell cycle progression.[supplied by OMIM, Apr 2004]

UniProt Comments for TOB2

TOB2: Anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases. Belongs to the BTG family.

Chromosomal Location of Human Ortholog: 22q13.2

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding; vitamin D receptor binding

Biological Process: negative regulation of cell proliferation; negative regulation of osteoclast differentiation; regulation of gene expression; female gamete generation; positive regulation of ossification
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Research Articles on TOB2

1. The antiproliferative and the mRNA deadenylation/decay-promoting effects of TOB1 and TOB2 proteins are linked.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TOB2 antibody

 Reference Product  PubMed Publications
 CNOT7 antibody  >5 publications with TOB2 and CNOT7

Pathways associated with anti-TOB2 antibody

 Products by Pathway  Pathway Diagram
 BMP Signalling And Regulation Pathway antibodies  BMP Signalling And Regulation Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram

Diseases associated with anti-TOB2 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >5 publications with TOB2 and Neoplasms
 Death Antibodies  >2 publications with TOB2 and Death
 Adenocarcinoma Antibodies  >1 publications with TOB2 and Adenocarcinoma
 Liver Neoplasms Antibodies  >1 publications with TOB2 and Liver Neoplasms
 Immune System Diseases Antibodies  >1 publications with TOB2 and Immune System Diseases
 Nervous System Diseases Antibodies  >1 publications with TOB2 and Nervous System Diseases
 Cell Transformation, Neoplastic Antibodies  >1 publications with TOB2 and Cell Transformation, Neoplastic
 Liver Diseases Antibodies  >1 publications with TOB2 and Liver Diseases
 Vitiligo Antibodies  >1 publications with TOB2 and Vitiligo

Organs/Tissues associated with anti-TOB2 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >8 publications with TOB2 and Bone
 Blood Antibodies  >7 publications with TOB2 and Blood
 Muscle Antibodies  >3 publications with TOB2 and Muscle
 Nerve Antibodies  >3 publications with TOB2 and Nerve
 Connective Tissue Antibodies  >1 publications with TOB2 and Connective Tissue
 Kidney Antibodies  >1 publications with TOB2 and Kidney
 Skin Antibodies  >1 publications with TOB2 and Skin
 Liver Antibodies  >1 publications with TOB2 and Liver
 Adipose Tissue Antibodies  >1 publications with TOB2 and Adipose Tissue
 Embryonic Tissue Antibodies  >1 publications with TOB2 and Embryonic Tissue
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