SEPT4 Antibody – Goat Polyclonal

This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer. [provided by RefSeq, Nov 2010]

SEPT4: Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli. Belongs to the septin family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Hydrolase; Cytoskeletal; Cell development/differentiation; Apoptosis

Chromosomal Location of Human Ortholog: 17q22

Cellular Component: cytoskeleton; mitochondrion; nucleus

Molecular Function: GTPase activity; protein binding; GTP binding; structural molecule activity

Biological Process: regulation of apoptosis; sperm mitochondrion organization and biogenesis; cell division; positive regulation of protein ubiquitination; metabolic process; apoptosis; positive regulation of apoptosis; brain development; cell cycle; sperm capacitation