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Scinderin (SCIN) Antibody – Mouse Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS645378

MBS645378 is an antibody targeting SCIN. Also known as Scinderin (SCIN, Adseverin, KIAA1905). Reactive in Human. Host: Mouse. More details

$880 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Scinderin, Polyclonal Antibody
Full Product Name
Scinderin (SCIN, Adseverin, KIAA1905)
Product Gene Name
anti-SCIN antibody
Product Synonym Names
Anti -Scinderin (SCIN, Adseverin, KIAA1905)
Immunogen Sequence
MAKLYMVSDA SGSMRVTVVA EENPFSMAML LSEECFILDH GAAKQIFVWK GKDANPQERK AAMKTAEEFL QQMNYSKNTQ IQVLPEGGET PIFKQFFKDW RDKDQSDGFG KVYVTEKVAQ IKQIPFDASK LHSSPQMAAQ HNMVDDGSGK VEIWRVENNG RIQVDQNSYG EFYGGDCYII LYTYPRGQII YTWQGANATR DELTTSAFLT VQLDRSLGGQ AVQIRVSQGK EPVHLLSLFK DKPLIIYKNG TSKKGGQAPA PPTRLFQVRR NLASITRIVE VDVDANSLNS NDVFVLKLPQ NSGYIWVGKG ASQEEEKGAE YVASVLKCKT LRIQEGEEPE EFWNSLGGKK DYQTSPLLET QAEDHPPRLY GCSNKTGRFV IEEIPGEFTQ DDLAEDDVML LDAWEQIFIW IGKDANEVEK KESLKSAKMY LETDPSGRDK RTPIVIIKQG HEPPTFTGWF LGWDSSKW
Clonality
Polyclonal
Isotype
IgG
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human SCIN.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
80,489 Da
Chromosome Location
Chromosome: 7; NC_000007.13 (12609989..12693228). Location: 7p21.3
OMIM
613416
3D Structure
ModBase 3D Structure for Q9Y6U3
Immunogen
Full length human SCIN, aa1-468 (NP_149119.1).

Product Categories/Family for anti-SCIN antibody

Antibodies; Abs to Actin Related Proteins
Applications Tested/Suitable for anti-SCIN antibody
Western Blot (WB)
Application Notes for anti-SCIN antibody
Suitable for use in Western Blot.

Western Blot (WB) of anti-SCIN antibody

SCIN polyclonal antibody. Western Blot analysis of SCIN expression in human kidney.
Mouse Anti-SCIN Polyclonal Antibody – Cat# MBS645378

Western Blot (WB) of anti-SCIN antibody

SCIN polyclonal antibody. Western Blot analysis of SCIN expression in human pancreas.
Mouse Anti-SCIN Polyclonal Antibody, Western Blot (WB) – Cat# MBS645378

Western Blot (WB) of anti-SCIN antibody

Western Blot analysis of SCIN expression in transfected 293T cell line by SCIN polyclonal antibody. Lane 1: SCIN transfected lysate (51.48kD). Lane 2: Non-transfected lysate.
Mouse Anti-SCIN Polyclonal Antibody, Western Blot (WB) – Cat# MBS645378

Other Notes

Small volumes of anti-SCIN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SCIN. It may not necessarily be applicable to this product.

NCBI GI #
14331131
NCBI GeneID
85477
NCBI Accession #
AAK60494.1
UniProt Primary Accession #
Q9Y6U3
UniProt Secondary Accession #
Q8NBZ6; Q8WU97; Q96JC7; Q96PY2; A8K2U8
UniProt Related Accession #
Q9Y6U3
NCBI Official Full Name
scinderin
NCBI Official Synonym Full Names
scinderin
NCBI Official Symbol
SCIN
UniProt Protein Name
Adseverin
UniProt Synonym Protein Names
Scinderin
Protein Family
Adseverin
UniProt Gene Name
SCIN
UniProt Synonym Gene Names
KIAA1905
UniProt Entry Name
ADSV_HUMAN
NCBI Protein Information
adseverin

NCBI Summary for SCIN

SCIN is a Ca(2+)-dependent actin-severing and -capping protein (Zunino et al., 2001 [PubMed 11568009]).[supplied by OMIM, May 2010]

UniProt Comments for SCIN

SCIN: Ca(2+)-dependent actin filament-severing protein that is presumed to have a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Regulates chondrocyte proliferation and differentiation. MAP kinases p38 and ERK1/2 mediate the adseverin-induced accelerated differentiation of non-hypertrophic chondrocytes. Belongs to the villin/gelsolin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 7p21.3

Cellular Component: cytoskeleton; protein complex; cytoplasm; cell cortex

Molecular Function: actin filament binding; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylserine binding; calcium ion binding; actin binding; phosphatidylinositol binding

Biological Process: negative regulation of cell proliferation; actin filament severing; positive regulation of apoptosis; actin filament capping; positive regulation of secretion; positive regulation of megakaryocyte differentiation; regulation of chondrocyte differentiation; calcium ion-dependent exocytosis; actin nucleation
Show more

Research Articles on SCIN

1. calcium binding to the N terminus of adseverin dominates the activation process to expose the F-actin binding site on A2

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-SCIN antibody

 Products by Pathway  Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram
 Viral Carcinogenesis Pathway antibodies  Viral Carcinogenesis Pathway Diagram
 Viral Carcinogenesis Pathway antibodies  Viral Carcinogenesis Pathway Diagram

Diseases associated with anti-SCIN antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >4 publications with SCIN and Nervous System Diseases
 Congenital Abnormalities Antibodies  >1 publications with SCIN and Congenital Abnormalities
 Liver Neoplasms Antibodies  >1 publications with SCIN and Liver Neoplasms
 Disease Models, Animal Antibodies  >1 publications with SCIN and Disease Models, Animal
 Heart Defects, Congenital Antibodies  >1 publications with SCIN and Heart Defects, Congenital
 Adenoma, Liver Cell Antibodies  >1 publications with SCIN and Adenoma, Liver Cell
 Abnormalities, Multiple Antibodies  >1 publications with SCIN and Abnormalities, Multiple
 Precancerous Conditions Antibodies  >1 publications with SCIN and Precancerous Conditions

Organs/Tissues associated with anti-SCIN antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >2 publications with SCIN and Lung
 Thymus Antibodies  >2 publications with SCIN and Thymus
 Kidney Antibodies  >2 publications with SCIN and Kidney
 Nerve Antibodies  >1 publications with SCIN and Nerve
 Prostate Antibodies  >1 publications with SCIN and Prostate
 Trachea Antibodies  >1 publications with SCIN and Trachea
 Brain Antibodies  >1 publications with SCIN and Brain
 Skin Antibodies  >1 publications with SCIN and Skin
 Testis Antibodies  >1 publications with SCIN and Testis
 Bone Antibodies  >1 publications with SCIN and Bone
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