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USP48 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS645443

This gene encodes a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Family members function as deubiquitinating enzymes, recognizing and hydrolyzing the peptide bond… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
USP48, Monoclonal Antibody
Full Product Name
USP48 (Ubiquitin Carboxyl-terminal Hydrolase 48, Deubiquitinating Enzyme 48, Ubiquitin Thioesterase 48, Ubiquitin-specific-processing Protease 48, USP31, DKFZp762M1713, MGC132556, MGC14879)
Product Gene Name
anti-USP48 antibody
Product Synonym Names
Anti -USP48 (Ubiquitin Carboxyl-terminal Hydrolase 48, Deubiquitinating Enzyme 48, Ubiquitin Thioesterase 48, Ubiquitin-specific-processing Protease 48, USP31, DKFZp762M1713, MGC132556, MGC14879)
Immunogen Sequence
NLELRQALYL CPSTCSDYML GDGIQEEKDY EPQTICEHLQ YLFALLQNSN RRYIDPSGFV KALGLDTGQQ QDAQEFSKLF MSLLEDTLSK QKNPDVRNIV QQQFCGEYAY
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
3G4
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human USP48.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
119,032 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (22004791..22109688, complement). Location: 1p36.12
3D Structure
ModBase 3D Structure for Q86UV5
Immunogen
Partial recombinant corresponding to aa110-220 from human USP48 (NP_115612) with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-USP48 antibody

Antibodies; Abs to Enzymes; Protease (Proteinase; Peptidase)
Applications Tested/Suitable for anti-USP48 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-USP48 antibody
Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 3ug/ml

Western Blot (WB) of anti-USP48 antibody

Western Blot detection against Immunogen (38.21kD).
Mouse Anti-USP48 Monoclonal Antibody – Cat# MBS645443

Western Blot (WB) of anti-USP48 antibody

USP48 monoclonal antibody, Western Blot analysis of USP48 expression in HeLa.
Mouse Anti-USP48 Monoclonal Antibody, Western Blot (WB) – Cat# MBS645443

Immunohistochemistry (IHC) of anti-USP48 antibody

Immunoperoxidase of monoclonal antibody to USP48 on formalin-fixed paraffin-embedded human colon. [antibody concentration 3ug/ml].
Mouse Anti-USP48 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS645443

Testing Data of anti-USP48 antibody

Detection limit for recombinant GST tagged USP48 is ~0.3ng/ml as a capture antibody.
Mouse Anti-USP48 Monoclonal Antibody, Testing Data – Cat# MBS645443

Other Notes

Small volumes of anti-USP48 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for USP48 purchase

MBS645443 is an antibody targeting USP48. Also known as USP48 (Ubiquitin Carboxyl-terminal Hydrolase 48, Deubiquitinating Enzyme 48, Ubiquitin Thioesterase 48, Ubiquitin-specific-processing Protease 48, USP31, DKFZp762M1713, MGC132556, MGC14879). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for USP48. It may not necessarily be applicable to this product.

NCBI GI #
219520976
NCBI GeneID
84196
NCBI Accession #
AAI43355.1
UniProt Primary Accession #
Q86UV5
UniProt Secondary Accession #
Q2M3I4; Q5SZI4; Q5T3T5; Q6NX53; Q8N3F6; Q96F64; Q96IQ3; Q9H5N3; Q9H5T7; Q9NUJ6; Q9NXR0
UniProt Related Accession #
Q86UV5
NCBI Official Full Name
USP48 protein
NCBI Official Synonym Full Names
ubiquitin specific peptidase 48
NCBI Official Symbol
USP48
NCBI Official Synonym Symbols
USP31; RAP1GA1
UniProt Protein Name
Ubiquitin carboxyl-terminal hydrolase 48
UniProt Synonym Protein Names
Deubiquitinating enzyme 48; Ubiquitin thioesterase 48; Ubiquitin-specific-processing protease 48
Protein Family
Ubiquitin carboxyl-terminal hydrolase
UniProt Gene Name
USP48
UniProt Synonym Gene Names
USP31
UniProt Entry Name
UBP48_HUMAN
NCBI Protein Information
ubiquitin carboxyl-terminal hydrolase 48; ubiquitin thioesterase 48; deubiquitinating enzyme 48; ubiquitin thiolesterase 48; ubiquitin specific protease 31; ubiquitin specific protease 48; ubiquitin-specific-processing protease 48

UniProt Comments for USP48

USP48: Recognizes and hydrolyzes the peptide bond at the C- terminal Gly of ubiquitin. Involved in the processing of poly- ubiquitin precursors as well as that of ubiquitinated proteins. May be involved in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites. Belongs to the peptidase C19 family. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin-specific protease; Protease; Ubiquitin conjugating system; EC 3.4.19.12

Chromosomal Location of Human Ortholog: 1p36.12

Cellular Component: nucleoplasm; mitochondrion; cytoplasm

Molecular Function: cysteine-type endopeptidase activity; ubiquitin-specific protease activity

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein deubiquitination
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-USP48 antibody

 Disease Name  Pubmed Publications
 Atherosclerosis Antibodies  >2 publications with USP48 and Atherosclerosis
 Cardiovascular Diseases Antibodies  >2 publications with USP48 and Cardiovascular Diseases
 Arteriosclerosis Antibodies  >1 publications with USP48 and Arteriosclerosis
 Inflammation Antibodies  >1 publications with USP48 and Inflammation
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