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MMRN1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS645471

Multimerin is a massive, soluble protein found in platelets and in the endothelium of blood vessels. It is comprised of subunits linked by interchain disulfide bonds to form large, variably sized homomultimers. Multimerin is a factor V/Va-binding protein and… More details

$880 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MMRN1, Monoclonal Antibody
Full Product Name
MMRN1 (ECM, EMILIN4, GPIA*, MMRN, Multimerin-1, EMILIN-4, Elastin Microfibril Interface Located Protein 4, Endothelial Cell Multimerin, Platelet Glycoprotein Ia*, 155kD Platelet Multimerin)
Product Gene Name
anti-MMRN1 antibody
Product Synonym Names
Anti -MMRN1 (ECM, EMILIN4, GPIA*, MMRN, Multimerin-1, EMILIN-4, Elastin Microfibril Interface Located Protein 4, Endothelial Cell Multimerin, Platelet Glycoprotein Ia*, 155kD Platelet Multimerin)
Immunogen Sequence
IHTNQAESHT AVGRGVAEQQ QQQGCGDPEV MQKMTDQVNY QAMKLTLLQK KIDNISLTVN DVRNTYSSLE GKVSEDKSRE FQSLLKGLKS KSINVLIRDI *
Clonality
Monoclonal
Isotype
IgG2b,k
Clone Number
4B9
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human MMRN1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
138,110 Da
Chromosome Location
Chromosome: 4; NC_000004.11 (90816003..90875780). Location: 4q22
OMIM
601456
3D Structure
ModBase 3D Structure for Q13201
Immunogen
Partial recombinant corresponding to aa291-391 from MMRN1 (NP_031377) with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-MMRN1 antibody

Antibodies; Abs to Elastin
Applications Tested/Suitable for anti-MMRN1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-MMRN1 antibody
Suitable for use in ELISA and Western Blot.

Western Blot (WB) of anti-MMRN1 antibody

Western Blot detection against Immunogen (37.11kD).
Mouse Anti-MMRN1 Monoclonal Antibody – Cat# MBS645471

Testing Data of anti-MMRN1 antibody

Detection limit for recombinant GST tagged MMRN1 is ~0.1ng/ml as a capture antibody.
Mouse Anti-MMRN1 Monoclonal Antibody, Testing Data – Cat# MBS645471

Other Notes

Small volumes of anti-MMRN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MMRN1 purchase

MBS645471 is an antibody targeting MMRN1. Also known as MMRN1 (ECM, EMILIN4, GPIA*, MMRN, Multimerin-1, EMILIN-4, Elastin Microfibril Interface Located Protein 4, Endothelial Cell Multimerin, Platelet Glycoprotein Ia*, 155kD Platelet Multimerin). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for MMRN1. It may not necessarily be applicable to this product.

NCBI GI #
45269141
NCBI GeneID
22915
NCBI Accession #
NP_031377.2
UniProt Primary Accession #
Q13201
UniProt Secondary Accession #
Q4W5L1; Q6P3T8; Q6ZUL9
UniProt Related Accession #
Q13201
GenBank Nucleotide #
NM_007351.2
NCBI Official Full Name
multimerin-1
NCBI Official Synonym Full Names
multimerin 1
NCBI Official Symbol
MMRN1
NCBI Official Synonym Symbols
ECM; MMRN; GPIa*; EMILIN4
UniProt Protein Name
Multimerin-1
UniProt Synonym Protein Names
EMILIN-4; Elastin microfibril interface located protein 4; Elastin microfibril interfacer 4; Endothelial cell multimerin
Protein Family
Multimerin
UniProt Gene Name
MMRN1
UniProt Synonym Gene Names
ECM; EMILIN4; GPIA*; MMRN; Elastin microfibril interfacer 4; p-155; p155
UniProt Entry Name
MMRN1_HUMAN
NCBI Protein Information
multimerin-1; EMILIN-4; glycoprotein Ia*; endothelial cell multimerin; elastin microfibril interfacer 4; elastin microfibril interface located protein 4

UniProt Comments for MMRN1

MMRN1: Carrier protein for platelet (but not plasma) factor V/Va. Plays a role in the storage and stabilization of factor V in platelets. Upon release following platelet activation, may limit platelet and plasma factor Va-dependent thrombin generation. Ligand for integrin alpha-IIb/beta-3 and integrin alpha-V/beta-3 on activated platelets, and may function as an extracellular matrix or adhesive protein. Deficiency in multimerin-1 due to proteolytic degradation within the platelet alpha granules is associated with an autosomal dominant bleeding disorder (factor V Quebec). 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 4q22

Cellular Component: extracellular region

Biological Process: platelet activation; platelet degranulation; blood coagulation; cell adhesion
Show more

Research Articles on MMRN1

1. Observational study of gene-disease association. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-MMRN1 antibody

 Products by Pathway  Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
 Response To Elevated Platelet Cytosolic Ca2+ Pathway antibodies  Response To Elevated Platelet Cytosolic Ca2+ Pathway Diagram

Diseases associated with anti-MMRN1 antibody

 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >2 publications with MMRN1 and Mental Disorders
 Dementia Antibodies  >2 publications with MMRN1 and Dementia
 Adenocarcinoma Antibodies  >2 publications with MMRN1 and Adenocarcinoma
 Inflammation Antibodies  >2 publications with MMRN1 and Inflammation
 Cardiovascular Diseases Antibodies  >1 publications with MMRN1 and Cardiovascular Diseases
 Ovarian Neoplasms Antibodies  >1 publications with MMRN1 and Ovarian Neoplasms
 Disease Models, Animal Antibodies  >1 publications with MMRN1 and Disease Models, Animal
 Endometrial Neoplasms Antibodies  >1 publications with MMRN1 and Endometrial Neoplasms

Organs/Tissues associated with anti-MMRN1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with MMRN1 and Brain
 Vascular Antibodies  >2 publications with MMRN1 and Vascular
 Lung Antibodies  >1 publications with MMRN1 and Lung
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