MACF1 Antibody – Mouse Monoclonal

This gene encodes a large protein containing numerous spectrin and leucine-rich repeat (LRR) domains. The encoded protein is a member of a family of proteins that form bridges between different cytoskeletal elements. This protein facilitates actin-microtubule interactions at the cell periphery and couples the microtubule network to cellular junctions. Alternative splicing results in multiple transcript variants, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, May 2013]

ACF7: a nuclear WD40-repeat protein. An F-actin-binding protein which may play a role in cross- linking actin to other cytoskeletal proteins. Also binds to microtubules. WD40 proteins are known to function as adaptors in pre-mrna processing and cytoskeleton assembly.

Protein type: Motility/polarity/chemotaxis; Actin-binding; Cytoskeletal

Chromosomal Location of Human Ortholog: 1p32-p31

Cellular Component: Golgi apparatus; microtubule; cytoskeleton; cytoplasm; plasma membrane; actin cytoskeleton

Molecular Function: actin filament binding; protein binding; microtubule binding; ATPase activity; calcium ion binding; actin binding

Biological Process: regulation of microtubule-based process; Wnt receptor signaling pathway; wound healing; mesoderm formation; metabolic process; positive regulation of axon extension; regulation of focal adhesion formation; Golgi to plasma membrane protein transport; establishment and/or maintenance of cell polarity; posttranslational protein targeting to membrane; cell cycle arrest; positive regulation of Wnt receptor signaling pathway