Mouse Anti-PSMG1 Monoclonal Antibody – Cat# MBS645546

Detection limit for recombinant GST tagged DSCR2 is ~0.03ng/ml as a capture antibody.

PSMG1 Antibody – Mouse Monoclonal

Name: PSMG1 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS645546
Price: 880 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS645546

Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric… More details

$880 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PSMG1, Monoclonal Antibody

Full Product Name

PSMG1 (Proteasome Assembly Chaperone 1, PAC-1, Chromosome 21 Leucine-rich Protein, C21-LRP, Down Syndrome Critical Region Protein 2, C21LRP, DSCR2, PAC1)

Product Gene Name

anti-PSMG1 antibody

Product Synonym Names

Anti -PSMG1 (Proteasome Assembly Chaperone 1, PAC-1, Chromosome 21 Leucine-rich Protein, C21-LRP, Down Syndrome Critical Region Protein 2, C21LRP, DSCR2, PAC1)

Immunogen Sequence

MAATFFGEVV KAPCRAGTED EEEEEEGRRE TPEDREVRLQ LARKREVRLL RRQTKTSLEV SLLEKYPCSK FIIAIGNNAV AFLSSFVMNS GVWEEVGCAK LWNEWCRTTD TTHLSSTEAF CVFYHLKSNP SVFLCQCSCY VAEDQQYQWL EKVFGSCPRK NMQITILTCR HVTDYKTSES TGSLPSPFLR ALKTQNFKDS ACCPLLEQPN IVHDLPAAVL SYCQVWKIPA ILYLCYTDVM KLDLITVEAF KPILS

Clonality

Monoclonal

Isotype

IgG2a,k

Clone Number

4F2

Host

Mouse

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Recognizes human DSCR2.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

32,854 Da

Chromosome Location

Chromosome: 21; NC_000021.8 (40449076..40555440, complement). Location: 21q22.3

OMIM

605296

3D Structure

ModBase 3D Structure for O95456

Immunogen

Full length recombinant corresponding to aa1-288 from DSCR2 (AAH03619) with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-PSMG1 antibody

Antibodies; Abs to Proteasomes

Applications Tested/Suitable for anti-PSMG1 antibody

ELISA (EL/EIA)

Application Notes for anti-PSMG1 antibody

Suitable for use in ELISA.

Other Notes

Small volumes of anti-PSMG1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PSMG1 purchase

MBS645546 is an antibody targeting PSMG1. Also known as PSMG1 (Proteasome Assembly Chaperone 1, PAC-1, Chromosome 21 Leucine-rich Protein, C21-LRP, Down Syndrome Critical Region Protein 2, C21LRP, DSCR2, PAC1). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for PSMG1. It may not necessarily be applicable to this product.

NCBI GI #

387849314

NCBI GeneID

8624

NCBI Accession #

NP_001248753.1

UniProt Primary Accession #

O95456

UniProt Secondary Accession #

Q6FHA3; Q6FHD3; Q6S713; B5BUN2

UniProt Related Accession #

O95456

GenBank Nucleotide #

NM_001261824.1

NCBI Official Full Name

proteasome assembly chaperone 1 isoform 3

NCBI Official Synonym Full Names

proteasome (prosome, macropain) assembly chaperone 1

NCBI Official Symbol

PSMG1

NCBI Official Synonym Symbols

PAC1; DSCR2; PAC-1; C21LRP; LRPC21

UniProt Protein Name

Proteasome assembly chaperone 1

UniProt Synonym Protein Names

Chromosome 21 leucine-rich protein; C21-LRP; Down syndrome critical region protein 2

Protein Family

Proteasome assembly chaperone

UniProt Gene Name

PSMG1

UniProt Synonym Gene Names

C21LRP; DSCR2; PAC1; PAC-1; C21-LRP

UniProt Entry Name

PSMG1_HUMAN

NCBI Protein Information

proteasome assembly chaperone 1; leucine rich protein C21-LRP; proteasome assembling chaperone 1; chromosome 21 leucine-rich protein; Down syndrome critical region gene 2; Down syndrome critical region protein 2

UniProt Comments for PSMG1

DSCR2: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization. Belongs to the PSMG1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: endoplasmic reticulum; cytoplasm; nucleus

Molecular Function: protein binding

Biological Process: granule cell precursor proliferation; proteasome assembly

Research Articles on PSMG1

1. PSMG1 mutation is associated with Crohn's disease.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-PSMG1 antibody

Disease Name	Pubmed Publications
Colitis, Ulcerative Antibodies	>4 publications with PSMG1 and Colitis, Ulcerative
Necrosis Antibodies	>2 publications with PSMG1 and Necrosis
Inflammation Antibodies	>1 publications with PSMG1 and Inflammation

Organs/Tissues associated with anti-PSMG1 antibody

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>6 publications with PSMG1 and Muscle
Kidney Antibodies	>2 publications with PSMG1 and Kidney
Brain Antibodies	>2 publications with PSMG1 and Brain
Vascular Antibodies	>1 publications with PSMG1 and Vascular
Heart Antibodies	>1 publications with PSMG1 and Heart
Pancreas Antibodies	>1 publications with PSMG1 and Pancreas
Liver Antibodies	>1 publications with PSMG1 and Liver
Testis Antibodies	>1 publications with PSMG1 and Testis