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GDI1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS645579

GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
GDI1, Polyclonal Antibody
Full Product Name
GDI1, CT (GDI1, GDIL, OPHN2, RABGDIA, XAP4, Rab GDP dissociation inhibitor alpha, Guanosine diphosphate dissociation inhibitor 1, Oligophrenin-2, Protein XAP-4)
Product Gene Name
anti-GDI1 antibody
Product Synonym Names
Anti -GDI1, CT (GDI1, GDIL, OPHN2, RABGDIA, XAP4, Rab GDP dissociation inhibitor alpha, Guanosine diphosphate dissociation inhibitor 1, Oligophrenin-2, Protein XAP-4)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
50,583 Da
Chromosome Location
Chromosome: X; NC_000023.10 (153665259..153671814). Location: Xq28
OMIM
300104
3D Structure
ModBase 3D Structure for P31150
Immunogen
GDI1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 415-443 amino acids from the C-terminal region of human GDI1.

Product Categories/Family for anti-GDI1 antibody

Antibodies; Abs to GTPase; Rab; Ras; Rho Proteins
Applications Tested/Suitable for anti-GDI1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-GDI1 antibody
Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Western Blot (WB) of anti-GDI1 antibody

GDI1 Antibody (C-term) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the GDI1 antibody detected the GDI1 protein (arrow).
Rabbit Anti-GDI1 Polyclonal Antibody – Cat# MBS645579

Other Notes

Small volumes of anti-GDI1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GDI1 purchase

MBS645579 is an antibody targeting GDI1. Also known as GDI1, CT (GDI1, GDIL, OPHN2, RABGDIA, XAP4, Rab GDP dissociation inhibitor alpha, Guanosine diphosphate dissociation inhibitor 1, Oligophrenin-2, Protein XAP-4). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GDI1. It may not necessarily be applicable to this product.

NCBI GI #
49457546
NCBI GeneID
2664
NCBI Accession #
CAG47072.1
UniProt Primary Accession #
P31150
UniProt Secondary Accession #
P50394; Q6FG50; Q7Z2G6; Q7Z2G9; Q7Z2H5; Q7Z2I6
UniProt Related Accession #
P31150
NCBI Official Full Name
GDI1
NCBI Official Synonym Full Names
GDP dissociation inhibitor 1
NCBI Official Symbol
GDI1
NCBI Official Synonym Symbols
1A; GDIL; MRX41; MRX48; OPHN2; XAP-4; RABGD1A; RABGDIA
UniProt Protein Name
Rab GDP dissociation inhibitor alpha
UniProt Synonym Protein Names
Guanosine diphosphate dissociation inhibitor 1; GDI-1; Oligophrenin-2; Protein XAP-4
Protein Family
Guanosine nucleotide diphosphate dissociation inhibitor
UniProt Gene Name
GDI1
UniProt Synonym Gene Names
GDIL; OPHN2; RABGDIA; XAP4; Rab GDI alpha; GDI-1
UniProt Entry Name
GDIA_HUMAN
NCBI Protein Information
rab GDP dissociation inhibitor alpha; GDI-1; protein XAP-4; rab GDI alpha; oligophrenin-2; mental retardation, X-linked 48; rab GDP-dissociation inhibitor, alpha; guanosine diphosphate dissociation inhibitor 1

UniProt Comments for GDI1

Function: Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.

Subunit structure: Interacts with RHOH. Interacts with RAB10; negatively regulates RAB10 association with membranes and activation. Ref.16 Ref.17

Subcellular location: Cytoplasm

By similarity.

Tissue specificity: Brain; predominant in neural and sensory tissues. Ref.15

Involvement in disease: Mental retardation, X-linked 41 (MRX41) [MIM:300849]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.19 Ref.20

Sequence similarities: Belongs to the Rab GDI family.
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Research Articles on GDI1

1. The results of this study identified RabGDI as a component of the switching mechanism that is required for commissural axons to change their response from attraction to repulsion at the intermediate target

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GDI1 antibody

 Reference Product  PubMed Publications
 OPHN1 antibody  >10 publications with GDI1 and OPHN1
 GDI2 antibody  >1 publications with GDI1 and GDI2
 ARHGDIB antibody  >1 publications with GDI1 and ARHGDIB
 ATP6AP1 antibody  >1 publications with GDI1 and ATP6AP1

Pathways associated with anti-GDI1 antibody

 Products by Pathway  Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram
 Rho GTPase Cycle Pathway antibodies  Rho GTPase Cycle Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Rho GTPases Pathway antibodies  Signaling By Rho GTPases Pathway Diagram
 Signaling Mediated By P38-alpha And P38-beta Pathway antibodies  Signaling Mediated By P38-alpha And P38-beta Pathway Diagram

Diseases associated with anti-GDI1 antibody

 Disease Name  Pubmed Publications
 Mental Retardation, X-Linked Antibodies  >17 publications with GDI1 and Mental Retardation, X-Linked
 Congenital Abnormalities Antibodies  >3 publications with GDI1 and Congenital Abnormalities
 Memory Disorders Antibodies  >3 publications with GDI1 and Memory Disorders
 Learning Disorders Antibodies  >2 publications with GDI1 and Learning Disorders
 Neoplasms Antibodies  >1 publications with GDI1 and Neoplasms
 Brain Diseases Antibodies  >1 publications with GDI1 and Brain Diseases
 Cognition Disorders Antibodies  >1 publications with GDI1 and Cognition Disorders

Organs/Tissues associated with anti-GDI1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >14 publications with GDI1 and Brain
 Nerve Antibodies  >4 publications with GDI1 and Nerve
 Muscle Antibodies  >1 publications with GDI1 and Muscle
 Embryonic Tissue Antibodies  >1 publications with GDI1 and Embryonic Tissue
 Eye Antibodies  >1 publications with GDI1 and Eye
 Kidney Antibodies  >1 publications with GDI1 and Kidney
 Testis Antibodies  >1 publications with GDI1 and Testis
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