Rabbit Anti-PAPD7 Polyclonal Antibody – Cat# MBS645603

POLS Antibody (Center) western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the POLS antibody detected the POLS protein (arrow).

PAPD7 Antibody – Rabbit Polyclonal

Name: PAPD7 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS645603
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS645603

The protein encoded by this gene is a DNA polymerase that is likely involved in DNA repair. In addition, the encoded protein may be required for sister chromatid adhesion. Alternatively spliced transcript variants that encode different isoforms have been… More details

$895 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

POLS (PAPD7), Polyclonal Antibody

Full Product Name

POLS, ID (PAPD7, POLS, TRF4, DNA polymerase sigma, DNA polymerase kappa, LAK-1, PAP-associated domain-containing protein 7, Terminal uridylyltransferase 5, Topoisomerase-related function protein 4-1)

Product Gene Name

anti-PAPD7 antibody

Product Synonym Names

Anti -POLS, ID (PAPD7, POLS, TRF4, DNA polymerase sigma, DNA polymerase kappa, LAK-1, PAP-associated domain-containing protein 7, Terminal uridylyltransferase 5, Topoisomerase-related function protein 4-1)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Human

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

59,874 Da

Chromosome Location

Chromosome: 5; NC_000005.9 (6714076..6757161). Location: 5p15

OMIM

605198

3D Structure

ModBase 3D Structure for Q5XG87

Immunogen

POLS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 151-180 amino acids from the Central region of human POLS.

Product Categories/Family for anti-PAPD7 antibody

Antibodies; Abs to Topoisomerases

Applications Tested/Suitable for anti-PAPD7 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-PAPD7 antibody

Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Other Notes

Small volumes of anti-PAPD7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PAPD7 purchase

MBS645603 is an antibody targeting PAPD7. Also known as POLS, ID (PAPD7, POLS, TRF4, DNA polymerase sigma, DNA polymerase kappa, LAK-1, PAP-associated domain-containing protein 7, Terminal uridylyltransferase 5, Topoisomerase-related function protein 4-1). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PAPD7. It may not necessarily be applicable to this product.

NCBI GI #

219518042

NCBI GeneID

11044

NCBI Accession #

AAI43883.1

UniProt Primary Accession #

Q5XG87

UniProt Secondary Accession #

O43289; Q17RZ1; Q9Y6C1; A8K1E2

UniProt Related Accession #

Q5XG87

NCBI Official Full Name

POLS protein

NCBI Official Synonym Full Names

PAP associated domain containing 7

NCBI Official Symbol

PAPD7

NCBI Official Synonym Symbols

LAK1; POLK; POLS; TRF4; LAK-1; TRF41; TRF4-1; TUTASE5

UniProt Protein Name

DNA polymerase sigma

UniProt Synonym Protein Names

DNA polymerase kappa; LAK-1; PAP-associated domain-containing protein 7; Terminal uridylyltransferase 5; TUTase 5; Topoisomerase-related function protein 4-1

UniProt Gene Name

PAPD7

UniProt Synonym Gene Names

POLS; TRF4; TUTase 5; TRF4-1

UniProt Entry Name

PAPD7_HUMAN

NCBI Protein Information

DNA polymerase sigma; TUTase 5; DNA polymerase kappa; terminal uridylyltransferase 5; polymerase (DNA directed) sigma; polymerase (DNA-directed) sigma; PAP-associated domain-containing protein 7; topoisomerase-related function protein 4-1

UniProt Comments for PAPD7

Function: DNA polymerase, probably involved in DNA repair. May play a role in sister chromatid cohesion. Does not play a role in replication-dependent histone mRNA degradation. Ref.7 Ref.9

Catalytic activity: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

Cofactor: Magnesium or manganese

By similarity.

Subcellular location: Nucleus

Probable.

Sequence similarities: Belongs to the DNA polymerase type-B-like family.Contains 1 PAP-associated domain.

Sequence caution: The sequence AAD45198.1 differs from that shown. Reason: Frameshift at position 474.

Research Articles on PAPD7

1. These results suggest that PAPD7 l is the major and active isoform of PAPD7 expressed in cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PAPD7 antibody

Products by Pathway	Pathway Diagram
RNA Degradation Pathway antibodies	RNA Degradation Pathway Diagram
RNA Degradation Pathway antibodies	RNA Degradation Pathway Diagram
TRAMP Complex Pathway antibodies	TRAMP Complex Pathway Diagram
TRAMP Complex Pathway antibodies	TRAMP Complex Pathway Diagram

Diseases associated with anti-PAPD7 antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>1 publications with PAPD7 and Nervous System Diseases
Neoplasms Antibodies	>1 publications with PAPD7 and Neoplasms
Brain Diseases Antibodies	>1 publications with PAPD7 and Brain Diseases

Organs/Tissues associated with anti-PAPD7 antibody

Organ/Tissue Name	Pubmed Publications
Eye Antibodies	>1 publications with PAPD7 and Eye
Brain Antibodies	>1 publications with PAPD7 and Brain