Rabbit Anti-SMUG1 Polyclonal Antibody – Cat# MBS645783

SMUG1 Antibody (N-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the SMUG1 antibody detected the SMUG1 protein (arrow).

SMUG1 Antibody – Rabbit Polyclonal

Name: SMUG1 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS645783
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS645783

SMUG1 is a glycosylase that removes uracil from single- and double-stranded DNA in nuclear chromatin, thus contributing to base excision repair. More details

$895 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SMUG1, Polyclonal Antibody

Full Product Name

SMUG1, NT (SMUG1, Single-strand selective monofunctional uracil DNA glycosylase)

Product Gene Name

anti-SMUG1 antibody

Product Synonym Names

Anti -SMUG1, NT (SMUG1, Single-strand selective monofunctional uracil DNA glycosylase)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Human

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

29,862 Da

Chromosome Location

Chromosome: 12; NC_000012.11 (54574142..54582778, complement). Location: 12q13.11-q13.3

OMIM

607753

3D Structure

ModBase 3D Structure for Q53HV7

Immunogen

SMUG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 42-71 amino acids from the N-terminal region of human SMUG1.

Product Categories/Family for anti-SMUG1 antibody

Antibodies; Abs to Enzymes

Applications Tested/Suitable for anti-SMUG1 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-SMUG1 antibody

Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Other Notes

Small volumes of anti-SMUG1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SMUG1 purchase

MBS645783 is an antibody targeting SMUG1. Also known as SMUG1, NT (SMUG1, Single-strand selective monofunctional uracil DNA glycosylase). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SMUG1. It may not necessarily be applicable to this product.

NCBI GI #

344925869

NCBI GeneID

23583

NCBI Accession #

NP_001230716.1

UniProt Primary Accession #

Q53HV7

UniProt Secondary Accession #

O95862; Q0D2M0; Q8NB71; Q9BWC8; A8K2K9

UniProt Related Accession #

Q53HV7

GenBank Nucleotide #

NM_001243787.1

NCBI Official Full Name

single-strand selective monofunctional uracil DNA glycosylase isoform 1

NCBI Official Synonym Full Names

single-strand-selective monofunctional uracil-DNA glycosylase 1

NCBI Official Symbol

SMUG1

NCBI Official Synonym Symbols

FDG; UNG3; HMUDG

UniProt Protein Name

Single-strand selective monofunctional uracil DNA glycosylase

Protein Family

Single-strand selective monofunctional uracil DNA glycosylase

UniProt Gene Name

SMUG1

UniProt Entry Name

SMUG1_HUMAN

NCBI Protein Information

single-strand selective monofunctional uracil DNA glycosylase

NCBI Summary for SMUG1

This gene encodes a protein that participates in base excision repair by removing uracil from single- and double-stranded DNA. Many alternatively spliced transcript variants exist for this gene; the full-length nature is known for some but not all of the variants. [provided by RefSeq, Aug 2011]

UniProt Comments for SMUG1

Function: Responsible for recognizing base lesions in the genome and initiating base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA and has a preference for single-stranded DNA substrates. The activity is greater against mismatches (U/G) than against matches (U/A). Excised uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine) and other oxidized damage. The activity is damage specificity and salt concentration-dependent. The general order of the preference for ssDNA and dsDNA is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at the low salt concentration. At the high concentration dsDNA (G pair) > dsDNA (A pair) > ssDNA. Ref.1 Ref.2 Ref.8 Ref.9

Subcellular location: Nucleus Ref.1 Ref.9.

Research Articles on SMUG1

1. There was no difference between SMUG1 proficient and depleted cells following continuous exposure.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-SMUG1 antibody

Products by Pathway	Pathway Diagram
Base Excision Repair Pathway antibodies	Base Excision Repair Pathway Diagram
Base Excision Repair Pathway antibodies	Base Excision Repair Pathway Diagram
Base Excision Repair Pathway antibodies	Base Excision Repair Pathway Diagram
Base-Excision Repair, AP Site Formation Pathway antibodies	Base-Excision Repair, AP Site Formation Pathway Diagram
Base-free Sugar-phosphate Removal Via The Single-nucleotide Replacement Pathway antibodies	Base-free Sugar-phosphate Removal Via The Single-nucleotide Replacement Pathway Diagram
Cleavage Of The Damaged Pyrimidine Pathway antibodies	Cleavage Of The Damaged Pyrimidine Pathway Diagram
DNA Repair Pathway antibodies	DNA Repair Pathway Diagram
Depyrimidination Pathway antibodies	Depyrimidination Pathway Diagram
Displacement Of DNA Glycosylase By APE1 Pathway antibodies	Displacement Of DNA Glycosylase By APE1 Pathway Diagram
Fluoropyrimidine Activity Pathway antibodies	Fluoropyrimidine Activity Pathway Diagram

Diseases associated with anti-SMUG1 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>10 publications with SMUG1 and Neoplasms
Carcinoma Antibodies	>3 publications with SMUG1 and Carcinoma
Genetic Predisposition to Disease Antibodies	>2 publications with SMUG1 and Genetic Predisposition to Disease
Hyperplasia Antibodies	>2 publications with SMUG1 and Hyperplasia
Breast Neoplasms Antibodies	>1 publications with SMUG1 and Breast Neoplasms
Nervous System Diseases Antibodies	>1 publications with SMUG1 and Nervous System Diseases
Inflammation Antibodies	>1 publications with SMUG1 and Inflammation

Organs/Tissues associated with anti-SMUG1 antibody

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>3 publications with SMUG1 and Liver
Brain Antibodies	>3 publications with SMUG1 and Brain
Lung Antibodies	>1 publications with SMUG1 and Lung
Muscle Antibodies	>1 publications with SMUG1 and Muscle
Lymph Node Antibodies	>1 publications with SMUG1 and Lymph Node
Embryonic Tissue Antibodies	>1 publications with SMUG1 and Embryonic Tissue
Kidney Antibodies	>1 publications with SMUG1 and Kidney
Skin Antibodies	>1 publications with SMUG1 and Skin