Rat Anti-TREML2 Monoclonal Antibody – Cat# MBS645833

Detection of TREML2 in M1 Mouse Cell Line by Flow Cytometry. M1 mouse myeloid leukemia cell line was stained with Rat Mouse TREML2/TLT-2 Monoclonal Antibody or isotype control antibody followed by Phycoerythrin-conjugated Rat IgG Secondary Antibody.

TREML2 Antibody – Rat Monoclonal

Name: TREML2 Antibody; Monoclonal; Rat; Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS645833
Price: 995 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS645833

TREML2, also called TLT-2 is a 33kD type I transmembrane cell surface receptor and member of the Trem family of receptor proteins. Mouse TLT-2 is synthesized as a 329aa precursor that contains a 24aa signal sequence, a 246aa extracellular domain (ECD), a 21aa… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TREML2, Monoclonal Antibody

Full Product Name

TREML2 (Trem-like Transcript 2 Protein, TLT-2, Triggering Receptor Expressed on Myeloid Cells-like Protein 2, Tlt2)

Product Gene Name

anti-TREML2 antibody

Product Synonym Names

Anti -TREML2 (Trem-like Transcript 2 Protein, TLT-2, Triggering Receptor Expressed on Myeloid Cells-like Protein 2, Tlt2)

Clonality

Monoclonal

Isotype

IgG2A

Clone Number

12K189

Host

Rat

Species Reactivity

Mouse

Form/Format

Supplied as a lyophilized powder in PBS, trehalose. Reconstitute with sterile PBS to 0.5mg/ml.

Purity/Purification

Affinity Purified
Purified by Protein A/G affinity chromatography.

Specificity

Recognizes mouse TREML2. Does not react with recombinant mouse TREM-1,-2,-2b, -3, -4, rmTREML1/TLT-1, rmTREML4/TLT-4, or recombinant human NKp44.

Preparation and Storage

Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

35,127 Da

Chromosome Location

Chromosome: 6; NC_000006.11 (41157552..41168925, complement). Location: 6p21.1

OMIM

609715

3D Structure

ModBase 3D Structure for Q5T2D2

Immunogen

Recombinant corresponding to aa25-270 from mouse TREML2 expressed in CHO-S cell line.

Product Categories/Family for anti-TREML2 antibody

Antibodies; Abs to Receptors

Applications Tested/Suitable for anti-TREML2 antibody

Flow Cytometry (FC/FACS)

Application Notes for anti-TREML2 antibody

Suitable for use in Flow Cytometry.
Dilution: Flow Cytometry: 2.5ug labels 10e6 cells

Other Notes

Small volumes of anti-TREML2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TREML2 purchase

MBS645833 is an antibody targeting TREML2. Also known as TREML2 (Trem-like Transcript 2 Protein, TLT-2, Triggering Receptor Expressed on Myeloid Cells-like Protein 2, Tlt2). Reactive in Mouse. Host: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for TREML2. It may not necessarily be applicable to this product.

NCBI GI #

170932501

NCBI GeneID

79865

NCBI Accession #

NP_079083.2

UniProt Primary Accession #

Q5T2D2

UniProt Secondary Accession #

Q08AP8; Q08AP9; Q8IWY0; Q9H8E9

UniProt Related Accession #

Q5T2D2

GenBank Nucleotide #

NM_024807.3

NCBI Official Full Name

trem-like transcript 2 protein

NCBI Official Synonym Full Names

triggering receptor expressed on myeloid cells-like 2

NCBI Official Symbol

TREML2

NCBI Official Synonym Symbols

TLT2; TLT-2; C6orf76; dJ238O23.1

UniProt Protein Name

Trem-like transcript 2 protein

UniProt Synonym Protein Names

Triggering receptor expressed on myeloid cells-like protein 2

Protein Family

Trem-like transcript 2 protein

UniProt Gene Name

TREML2

UniProt Synonym Gene Names

C6orf76; TLT2; TLT-2

UniProt Entry Name

TRML2_HUMAN

NCBI Protein Information

trem-like transcript 2 protein; triggering receptor expressed on myeloid cells-like protein 2

NCBI Summary for TREML2

TREML2 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties (Allcock et al., 2003 [PubMed 12645956]).[supplied by OMIM, Mar 2008]

UniProt Comments for TREML2

Function: Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation. Ref.1 Ref.6

Subunit structure: Interacts with CD276 and this interaction enhances T-cell activation. Ref.6

Subcellular location: Cell membrane; Single-pass type I membrane protein

By similarity.

Tissue specificity: Detected in cultured B-cells, T-cell leukemia and monocyte leukemia. Expressed constitutively on CD8 T-cells and induced on CD4 T-cells after activation. Ref.1 Ref.6

Induction: Induced in CD4 T-cells by concanavalin-A. Ref.6

Sequence similarities: Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Sequence caution: The sequence AAI25079.1 differs from that shown. Reason: Erroneous initiation. The sequence AAI25080.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB14668.1 differs from that shown. Reason: Erroneous initiation. The sequence CAI19858.1 differs from that shown. Reason: Erroneous initiation. The sequence CAI19909.1 differs from that shown. Reason: Erroneous initiation.

Research Articles on TREML2

1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TREML2 antibody

Reference Product	PubMed Publications
CD276 antibody	>4 publications with TREML2 and CD276
TREM1 antibody	>2 publications with TREML2 and TREM1

Diseases associated with anti-TREML2 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>1 publications with TREML2 and Neoplasms

Organs/Tissues associated with anti-TREML2 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>4 publications with TREML2 and Blood