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CALU Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS645867

The product of this gene is a calcium-binding protein localized in the endoplasmic reticulum (ER) and it is involved in such ER functions as protein folding and sorting. This protein belongs to a family of multiple EF-hand proteins (CERC) that include… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CALU, Polyclonal Antibody
Full Product Name
CALU, CT (CALU, Calumenin, Crocalbin, IEF SSP 9302)
Product Gene Name
anti-CALU antibody
Product Synonym Names
Anti -CALU, CT (CALU, Calumenin, Crocalbin, IEF SSP 9302)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
37,107 Da
Chromosome Location
Chromosome: 7; NC_000007.13 (128379346..128413477). Location: 7q32.1
OMIM
603420
3D Structure
ModBase 3D Structure for O43852
Immunogen
CALU antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 216-246 amino acids from the C-terminal region of human CALU.

Product Categories/Family for anti-CALU antibody

Antibodies; Abs to Proteins
Applications Tested/Suitable for anti-CALU antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-CALU antibody
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:10-50

Western Blot (WB) of anti-CALU antibody

CALU Antibody (C-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the CALU antibody detected the CALU protein (arrow).
Rabbit Anti-CALU Polyclonal Antibody – Cat# MBS645867

Immunohistochemistry (IHC) of anti-CALU antibody

CALU Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CALU Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-CALU Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS645867

Other Notes

Small volumes of anti-CALU antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CALU purchase

MBS645867 is an antibody targeting CALU. Also known as CALU, CT (CALU, Calumenin, Crocalbin, IEF SSP 9302). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CALU. It may not necessarily be applicable to this product.

NCBI GI #
314122181
NCBI GeneID
813
NCBI Accession #
NP_001186602.1
UniProt Primary Accession #
O43852
UniProt Secondary Accession #
B3KPG9; D6QS48; D6QS49; D6QS50; D6QS51; D6QS52; D6QS53; D6QS54; D6QS55; D6QS56; D6QS57
UniProt Related Accession #
O43852
GenBank Nucleotide #
NM_001199673.1
NCBI Official Full Name
calumenin isoform e
NCBI Official Synonym Full Names
calumenin
NCBI Official Symbol
CALU
UniProt Protein Name
Calumenin
UniProt Synonym Protein Names
Crocalbin; IEF SSP 9302
Protein Family
Calumenin
UniProt Gene Name
CALU
UniProt Entry Name
CALU_HUMAN
NCBI Protein Information
calumenin; IEF SSP 9302; crocalbin-like protein; multiple EF-hand protein

UniProt Comments for CALU

Function: Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity

By similarity.

Subunit structure: Interacts with GGCX

By similarity.

Subcellular location: Endoplasmic reticulum lumen. Secreted. Melanosome. Sarcoplasmic reticulum lumen

By similarity. Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Ref.12 Ref.13 Ref.14

Tissue specificity: Ubiquitously expressed. Expressed at high levels in heart, placenta and skeletal muscle, at lower levels in lung, kidney and pancreas and at very low levels in brain and liver.

Sequence similarities: Belongs to the CREC family.Contains 6 EF-hand domains.
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Research Articles on CALU

1. Calumenin is a new CFTR chaperone.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CALU antibody

 Reference Product  PubMed Publications
 CFTR antibody  >133 publications with CALU and CFTR
 VKORC1 antibody  >22 publications with CALU and VKORC1
 ATP2A2 antibody  >3 publications with CALU and ATP2A2
 RYR2 antibody  >2 publications with CALU and RYR2
 P2RY2 antibody  >1 publications with CALU and P2RY2

Pathways associated with anti-CALU antibody

 Products by Pathway  Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
 Response To Elevated Platelet Cytosolic Ca2+ Pathway antibodies  Response To Elevated Platelet Cytosolic Ca2+ Pathway Diagram

Diseases associated with anti-CALU antibody

 Disease Name  Pubmed Publications
 Lung Diseases Antibodies  >292 publications with CALU and Lung Diseases
 Lung Neoplasms Antibodies  >265 publications with CALU and Lung Neoplasms
 Fibrosis Antibodies  >167 publications with CALU and Fibrosis
 Inflammation Antibodies  >50 publications with CALU and Inflammation
 Breast Neoplasms Antibodies  >47 publications with CALU and Breast Neoplasms
 Necrosis Antibodies  >24 publications with CALU and Necrosis
 Liver Neoplasms Antibodies  >11 publications with CALU and Liver Neoplasms
 Hepatitis Antibodies  >10 publications with CALU and Hepatitis
 Nervous System Diseases Antibodies  >10 publications with CALU and Nervous System Diseases
 Liver Diseases Antibodies  >10 publications with CALU and Liver Diseases

Organs/Tissues associated with anti-CALU antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >582 publications with CALU and Lung
 Blood Antibodies  >101 publications with CALU and Blood
 Vascular Antibodies  >47 publications with CALU and Vascular
 Kidney Antibodies  >37 publications with CALU and Kidney
 Brain Antibodies  >29 publications with CALU and Brain
 Liver Antibodies  >27 publications with CALU and Liver
 Intestine Antibodies  >20 publications with CALU and Intestine
 Muscle Antibodies  >19 publications with CALU and Muscle
 Prostate Antibodies  >19 publications with CALU and Prostate
 Ovary Antibodies  >17 publications with CALU and Ovary
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