Rabbit Anti-KCNJ15 Polyclonal Antibody – Cat# MBS645874

Western Blot analysis in MDA-MB231 cell line lysates (35ug/lane) using MBS645874. This demonstrates that MBS645874 detected the KCNJ15 protein (arrow).

KCNJ15 Antibody – Rabbit Polyclonal

Name: KCNJ15 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS645874
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS645874

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein has a… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

KCNJ15, Polyclonal Antibody

Full Product Name

KCNJ15, CT (KCNJ15, KCNJ14, ATP-sensitive inward rectifier potassium channel 15, Inward rectifier K(+) channel Kir1.3, Inward rectifier K(+) channel Kir4.2, Potassium channel, inwardly rectifying subfamily J member 15)

Product Gene Name

anti-Kcnj15 antibody

Product Synonym Names

Anti -KCNJ15, CT (KCNJ15, KCNJ14, ATP-sensitive inward rectifier potassium channel 15, Inward rectifier K(+) channel Kir1.3, Inward rectifier K(+) channel Kir4.2, Potassium channel, inwardly rectifying subfamily J member 15)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Human

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

42,605 Da

Chromosome Location

Chromosome: 16; NC_000082.6 (95257651..95300260). Location: 16 C4; 16 55.86 cM

3D Structure

ModBase 3D Structure for O88932

Immunogen

KCNJ15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 338-367 amino acids from the C-terminal region of human KCNJ15.

Product Categories/Family for anti-Kcnj15 antibody

Antibodies; Abs to Ion Channel

Applications Tested/Suitable for anti-Kcnj15 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-Kcnj15 antibody

Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Other Notes

Small volumes of anti-Kcnj15 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Kcnj15 purchase

MBS645874 is an antibody targeting Kcnj15. Also known as KCNJ15, CT (KCNJ15, KCNJ14, ATP-sensitive inward rectifier potassium channel 15, Inward rectifier K(+) channel Kir1.3, Inward rectifier K(+) channel Kir4.2, Potassium channel, inwardly rectifying subfamily J member 15). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Kcnj15. It may not necessarily be applicable to this product.

NCBI GI #

187951063

NCBI GeneID

16516

NCBI Accession #

AAI38479.1

UniProt Primary Accession #

O88932

UniProt Secondary Accession #

Q9JK34

UniProt Related Accession #

O88932

NCBI Official Full Name

Kcnj15 protein

NCBI Official Synonym Full Names

potassium inwardly-rectifying channel, subfamily J, member 15

NCBI Official Symbol

Kcnj15

NCBI Official Synonym Symbols

IRKK; Kir4.2; AI182284; AI267127; 4930414N08Rik

UniProt Protein Name

ATP-sensitive inward rectifier potassium channel 15

UniProt Synonym Protein Names

Inward rectifier K(+) channel Kir4.2; Potassium channel, inwardly rectifying subfamily J member 15

Protein Family

ATP-sensitive inward rectifier potassium channel

UniProt Gene Name

Kcnj15

UniProt Entry Name

IRK15_MOUSE

NCBI Protein Information

ATP-sensitive inward rectifier potassium channel 15; inward rectifier K+ channel Kir4.2; potassium channel, inwardly rectifying subfamily J member 15

UniProt Comments for Kcnj15

Function: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.

Subunit structure: Interacts with INADL

By similarity.

Subcellular location: Membrane; Multi-pass membrane protein.

Sequence similarities: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ15 subfamily. [View classification]

Research Articles on Kcnj15

1. It was shown that downregulation of Kcnj15 leads to increased insulin secretion in vitro and in vivo. The mechanism for regulating insulin secretion inolved a calcium-sensiong receptor.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Kcnj15 antibody

Products by Pathway	Pathway Diagram
Activation Of G Protein Gated Potassium Channels Pathway antibodies	Activation Of G Protein Gated Potassium Channels Pathway Diagram
Activation Of GABAB Receptors Pathway antibodies	Activation Of GABAB Receptors Pathway Diagram
G Protein Gated Potassium Channels Pathway antibodies	G Protein Gated Potassium Channels Pathway Diagram
GABA B Receptor Activation Pathway antibodies	GABA B Receptor Activation Pathway Diagram
GABA Receptor Activation Pathway antibodies	GABA Receptor Activation Pathway Diagram
Gastric Acid Secretion Pathway antibodies	Gastric Acid Secretion Pathway Diagram
Gastric Acid Secretion Pathway antibodies	Gastric Acid Secretion Pathway Diagram
Inhibition Of Voltage Gated Ca2+ Channels Via Gbeta/gamma Subunits Pathway antibodies	Inhibition Of Voltage Gated Ca2+ Channels Via Gbeta/gamma Subunits Pathway Diagram
Inwardly Rectifying K+ Channels Pathway antibodies	Inwardly Rectifying K+ Channels Pathway Diagram
Neuronal System Pathway antibodies	Neuronal System Pathway Diagram

Diseases associated with anti-Kcnj15 antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>1 publications with Kcnj15 and Nervous System Diseases
Neoplasms Antibodies	>1 publications with Kcnj15 and Neoplasms
Liver Diseases Antibodies	>1 publications with Kcnj15 and Liver Diseases
Heart Defects, Congenital Antibodies	>1 publications with Kcnj15 and Heart Defects, Congenital
Kidney Diseases Antibodies	>1 publications with Kcnj15 and Kidney Diseases
Inflammation Antibodies	>1 publications with Kcnj15 and Inflammation

Organs/Tissues associated with anti-Kcnj15 antibody

Organ/Tissue Name	Pubmed Publications
Kidney Antibodies	>6 publications with Kcnj15 and Kidney
Thymus Antibodies	>1 publications with Kcnj15 and Thymus
Liver Antibodies	>1 publications with Kcnj15 and Liver