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LEFTY2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS645876

During vertebrate embryogenesis, a left-right axis is established. Secreted growth factors of the TGF-beta family, including gene products derived from nodal, lefty-1 and lefty-2, play crucial roles in establishing left-right asymmetries. TGF-beta… More details

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Testing Data View PDF
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Product Overview

Online Datasheet in PDF
Product Name
LEFTYA (LEFTY2), Polyclonal Antibody
Full Product Name
LEFTYA (Left-right Determination Factor 2, Protein Lefty-2, Left-right Determination Factor A, Protein Lefty-A, Transforming Growth Factor beta-4, TGF-beta-4, Endometrial Bleeding-associated Factor, EBAF, LEFTA, LEFTY2, TGFB4, PSEC0024, MGC46222)
Product Gene Name
anti-LEFTY2 antibody
Product Synonym Names
Anti -LEFTYA (Left-right Determination Factor 2, Protein Lefty-2, Left-right Determination Factor A, Protein Lefty-A, Transforming Growth Factor beta-4, TGF-beta-4, Endometrial Bleeding-associated Factor, EBAF, LEFTA, LEFTY2, TGFB4, PSEC0024, MGC46222)
Immunogen Sequence
MWPLWLCWAL WVLPLAGPGA ALTEEQLLGS LLRQLQLSEV PVLDRADMEK LVIPAHVRAQ YVVLLRRSHG DRSRGKRFSQ SFREVAGRFL ASEASTHLLV FGMEQRLPPN SELVQAVLRL FQEPVPKAAL HRHGRLSPRS AQARVTVEWL RVRDDGSNRT SLIDSRLVSV HESGWKAFDV TEAVNFWQQL SRPRQPLLLQ VSVQREHLGP LASGAHKLVR FASQGAPAGL GEPQLELHTL DLRDYGAQGD CDPEAPMTEG TRCCRQEMYI DLQGMKWAKN WVLEPPGFLA YECVGTCQQP PEALAFNWPF LGPRQCIASE TASLPMIVSI KEGGRTRPQV VSLPNMRVQK CSCASDGALV PRRLQP
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid.
Purity/Purification
Serum
Serum
Specificity
Recognizes human LEFTY2.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
40,920 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (226124298..226129083, complement). Location: 1q42.1
OMIM
601877
3D Structure
ModBase 3D Structure for O00292
Immunogen
Full length human LEFTY2, aa1-366 (NP_003231.2).

Product Categories/Family for anti-LEFTY2 antibody

Antibodies; Abs to Growth Factors; Cytokines
Applications Tested/Suitable for anti-LEFTY2 antibody
Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-LEFTY2 antibody
Suitable for use in Western Blot and Immunoprecipitation.

Western Blot (WB) of anti-LEFTY2 antibody

Western Blot analysis of LEFTY2 expression in transfected 293T cell line by LEFTY2 polyclonal antibody. Lane 1: LEFTY2 transfected lysate (40.9kD). Lane 2: Non-transfected lysate.
Rabbit Anti-LEFTY2 Polyclonal Antibody – Cat# MBS645876

Immunoprecipitation (IP) of anti-LEFTY2 antibody

Immunoprecipitation of LEFTY2 transfected lysate using LEFTY2 rabbit polyclonal antibody and Protein A Magnetic Bead and immunoblotted with LEFTY2 purified mouse polyclonal antibody.
Rabbit Anti-LEFTY2 Polyclonal Antibody, Immunoprecipitation (IP) – Cat# MBS645876

Other Notes

Small volumes of anti-LEFTY2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LEFTY2 purchase

MBS645876 is an antibody targeting LEFTY2. Also known as LEFTYA (Left-right Determination Factor 2, Protein Lefty-2, Left-right Determination Factor A, Protein Lefty-A, Transforming Growth Factor beta-4, TGF-beta-4, Endometrial Bleeding-associated Factor, EBAF, LEFTA, LEFTY2, TGFB4, PSEC0024, MGC46222). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for LEFTY2. It may not necessarily be applicable to this product.

NCBI GI #
289063399
NCBI GeneID
7044
NCBI Accession #
NP_001165896.1
UniProt Primary Accession #
O00292
UniProt Secondary Accession #
O75611; Q5TE89; Q8NBQ9; B3KNH4; B4E332; E9PDM4
UniProt Related Accession #
O00292
GenBank Nucleotide #
NM_001172425.1
NCBI Official Full Name
left-right determination factor 2 isoform 2 preproprotein
NCBI Official Synonym Full Names
left-right determination factor 2
NCBI Official Symbol
LEFTY2
NCBI Official Synonym Symbols
EBAF; LEFTA; TGFB4; LEFTYA
UniProt Protein Name
Left-right determination factor 2
UniProt Synonym Protein Names
Endometrial bleeding-associated factor; Left-right determination factor A; Protein lefty-2; Protein lefty-A; Transforming growth factor beta-4
Protein Family
Left-right determination factor
UniProt Gene Name
LEFTY2
UniProt Synonym Gene Names
EBAF; LEFTA; LEFTYA; TGFB4; TGF-beta-4
UniProt Entry Name
LFTY2_HUMAN
NCBI Protein Information
left-right determination factor 2; TGF-beta-4; protein lefty-2; protein lefty-A; left-right determination factor A; transforming growth factor beta-4; endometrial bleeding-associated factor

NCBI Summary for LEFTY2

This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2010]
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UniProt Comments for LEFTY2

Function: Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding.

Subcellular location: Secreted.

Tissue specificity: Mesenchymal cells of the endometrial stroma.

Developmental stage: Transiently expressed before and during menstrual bleeding.

Post-translational modification: The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.

Involvement in disease: Left-right axis malformations (LRAM) [MIM:601877]: The defect includes left pulmonary isomerism, with cardiac anomalies characterized by complete atrioventricular canal defect and hypoplastic left ventricle, and interrupted inferior vena cava.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.2

Sequence similarities: Belongs to the TGF-beta family.

Sequence caution: The sequence AAB53269.1 differs from that shown. Reason: Authors have revised their sequence, but have not submitted the revised DNA sequence.
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Research Articles on LEFTY2

1. Lefty A may account for the tumor suppressive activity of human adult stem cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-LEFTY2 antibody

 Reference Product  PubMed Publications
 NODAL antibody  >44 publications with LEFTY2 and NODAL
 PITX2 antibody  >25 publications with LEFTY2 and PITX2
 TDGF1 antibody  >3 publications with LEFTY2 and TDGF1
 CFC1 antibody  >3 publications with LEFTY2 and CFC1
 ZIC3 antibody  >2 publications with LEFTY2 and ZIC3
 TGFB1 antibody  >2 publications with LEFTY2 and TGFB1
 INVS antibody  >1 publications with LEFTY2 and INVS

Pathways associated with anti-LEFTY2 antibody

 Products by Pathway  Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
 Regulation Of Signaling By NODAL Pathway antibodies  Regulation Of Signaling By NODAL Pathway Diagram
 Response To Elevated Platelet Cytosolic Ca2+ Pathway antibodies  Response To Elevated Platelet Cytosolic Ca2+ Pathway Diagram
 Signaling By NODAL Pathway antibodies  Signaling By NODAL Pathway Diagram
 TGF Beta Signaling Pathway antibodies  TGF Beta Signaling Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram

Diseases associated with anti-LEFTY2 antibody

 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >6 publications with LEFTY2 and Heart Diseases
 Cardiovascular Diseases Antibodies  >6 publications with LEFTY2 and Cardiovascular Diseases
 Neoplasms Antibodies  >5 publications with LEFTY2 and Neoplasms
 Abnormalities, Multiple Antibodies  >3 publications with LEFTY2 and Abnormalities, Multiple
 Adenocarcinoma Antibodies  >2 publications with LEFTY2 and Adenocarcinoma
 Disease Models, Animal Antibodies  >1 publications with LEFTY2 and Disease Models, Animal
 Pain Antibodies  >1 publications with LEFTY2 and Pain
 Endometrial Neoplasms Antibodies  >1 publications with LEFTY2 and Endometrial Neoplasms
 Edema Antibodies  >1 publications with LEFTY2 and Edema
 Breast Neoplasms Antibodies  >1 publications with LEFTY2 and Breast Neoplasms

Organs/Tissues associated with anti-LEFTY2 antibody

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >21 publications with LEFTY2 and Heart
 Embryonic Tissue Antibodies  >15 publications with LEFTY2 and Embryonic Tissue
 Uterus Antibodies  >13 publications with LEFTY2 and Uterus
 Placenta Antibodies  >7 publications with LEFTY2 and Placenta
 Brain Antibodies  >4 publications with LEFTY2 and Brain
 Kidney Antibodies  >4 publications with LEFTY2 and Kidney
 Eye Antibodies  >3 publications with LEFTY2 and Eye
 Connective Tissue Antibodies  >2 publications with LEFTY2 and Connective Tissue
 Ovary Antibodies  >2 publications with LEFTY2 and Ovary
 Intestine Antibodies  >2 publications with LEFTY2 and Intestine
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