Rabbit Anti-NR2E1 Polyclonal Antibody – Cat# MBS645878

NR2E1 Antibody (Center) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the NR2E1 antibody detected the NR2E1 protein (arrow).

NR2E1 Antibody – Rabbit Polyclonal

Name: NR2E1 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS645878
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS645878

Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. May be required for brain… More details

$895 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

NR2E1, Polyclonal Antibody

Full Product Name

NR2E1, ID (NR2E1, TLX, Nuclear receptor subfamily 2 group E member 1, Nuclear receptor TLX, Protein tailless homolog)

Product Gene Name

anti-NR2E1 antibody

Product Synonym Names

Anti -NR2E1, ID (NR2E1, TLX, Nuclear receptor subfamily 2 group E member 1, Nuclear receptor TLX, Protein tailless homolog)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Human

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

42,589 Da

Chromosome Location

Chromosome: 6; NC_000006.11 (108487215..108510013). Location: 6q21

OMIM

603849

3D Structure

ModBase 3D Structure for Q9Y466

Immunogen

NR2E1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 75-102 amino acids from the Central region of human NR2E1.

Product Categories/Family for anti-NR2E1 antibody

Antibodies; Abs to Receptors

Applications Tested/Suitable for anti-NR2E1 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-NR2E1 antibody

Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Other Notes

Small volumes of anti-NR2E1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NR2E1 purchase

MBS645878 is an antibody targeting NR2E1. Also known as NR2E1, ID (NR2E1, TLX, Nuclear receptor subfamily 2 group E member 1, Nuclear receptor TLX, Protein tailless homolog). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NR2E1. It may not necessarily be applicable to this product.

NCBI GI #

4507537

NCBI GeneID

7101

NCBI Accession #

NP_003260.1

UniProt Primary Accession #

Q9Y466

UniProt Related Accession #

Q9Y466

GenBank Nucleotide #

NM_003269.3

NCBI Official Full Name

nuclear receptor subfamily 2 group E member 1

NCBI Official Synonym Full Names

nuclear receptor subfamily 2, group E, member 1

NCBI Official Symbol

NR2E1

NCBI Official Synonym Symbols

TLL; TLX; XTLL

UniProt Protein Name

Nuclear receptor subfamily 2 group E member 1

UniProt Synonym Protein Names

Nuclear receptor TLX; Protein tailless homolog

Protein Family

Nuclear receptor subfamily

UniProt Gene Name

NR2E1

UniProt Synonym Gene Names

TLX; Tll; hTll

UniProt Entry Name

NR2E1_HUMAN

NCBI Protein Information

nuclear receptor subfamily 2 group E member 1; hTll; tailless homolog; nuclear receptor TLX; tailes-related receptor; protein tailless homolog

NCBI Summary for NR2E1

The protein encoded by this gene is an orphan receptor involved in retinal development. The encoded protein also regulates adult neural stem cell proliferation and may be involved in control of aggressive behavior. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

UniProt Comments for NR2E1

Function: Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity

By similarity. May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity

By similarity. May be involved in retinoic acic receptor (RAR) regulation in retinal cells. Ref.2

Subunit structure: Monomer

By similarity. Interacts with ATN1; the interaction represses the transcription

By similarity.

Subcellular location: Nucleus

By similarity.

Tissue specificity: Brain specific. Present in all brain sections tested, highest levels in the caudate nucleus and hippocampus, weakest levels in the thalamus. Ref.1

Sequence similarities: Belongs to the nuclear hormone receptor family. NR2 subfamily.Contains 1 nuclear receptor DNA-binding domain.

Research Articles on NR2E1

1. TLX/NR2E1 and related NRs such as PNR and COUPTFs can selectively associate with the developmental corepressor BCL11A via a conserved motif F/YSXXLXXL/Y within the RID1 and RID2 domains. The interaction with BCL11A facilitates TLX-mediated repression of the RARb2 gene.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NR2E1 antibody

Reference Product	PubMed Publications
NR4A2 antibody	>1 publications with NR2E1 and NR4A2
NR5A1 antibody	>1 publications with NR2E1 and NR5A1

Pathways associated with anti-NR2E1 antibody

Products by Pathway	Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Generic Transcription Pathway antibodies	Generic Transcription Pathway Diagram
Nuclear Receptor Transcription Pathway antibodies	Nuclear Receptor Transcription Pathway Diagram
Nuclear Receptors Pathway antibodies	Nuclear Receptors Pathway Diagram

Diseases associated with anti-NR2E1 antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>12 publications with NR2E1 and Nervous System Diseases
Congenital Abnormalities Antibodies	>10 publications with NR2E1 and Congenital Abnormalities
Eye Abnormalities Antibodies	>6 publications with NR2E1 and Eye Abnormalities
Craniofacial Abnormalities Antibodies	>2 publications with NR2E1 and Craniofacial Abnormalities
Musculoskeletal Abnormalities Antibodies	>2 publications with NR2E1 and Musculoskeletal Abnormalities
Abnormalities, Multiple Antibodies	>2 publications with NR2E1 and Abnormalities, Multiple
Disease Models, Animal Antibodies	>1 publications with NR2E1 and Disease Models, Animal
Atrophy Antibodies	>1 publications with NR2E1 and Atrophy
Glioblastoma Antibodies	>1 publications with NR2E1 and Glioblastoma
Growth Disorders Antibodies	>1 publications with NR2E1 and Growth Disorders

Organs/Tissues associated with anti-NR2E1 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>42 publications with NR2E1 and Brain
Eye Antibodies	>15 publications with NR2E1 and Eye
Placenta Antibodies	>1 publications with NR2E1 and Placenta