NUP210 Antibody – Rabbit Polyclonal

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a membrane-spanning glycoprotein that is a major component of the nuclear pore complex. Multiple pseudogenes related to this gene are located on chromosome 3. [provided by RefSeq, Jul 2013]

Function: Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity. Ref.8

Subunit structure: Forms dimers and possibly higher-order oligomers

By similarity.

Subcellular location: Nucleus › nuclear pore complex. Nucleus membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein Ref.7.

Tissue specificity: Ubiquitous expression, with highest levels in lung, liver, pancreas, testis, and ovary, intermediate levels in brain, kidney, and spleen, and lowest levels in heart and skeletal muscle. Ref.4

Post-translational modification: N-glycosylated, but not all potential glycosylation sites may be used. Contains high-mannose type oligosaccharides

By similarity.Phosphorylated at Ser-1881 in mitosis specifically; not phosphorylated in interphase

By similarity.

Miscellaneous: Recognized by antinuclear autoantibodies in primary biliary cirrhosis.Knockdown of NUP210 causes nuclear membranes to accumulate aberrant structures termed twinned and fusion-arrested membranes and nuclear pore complex to cluster. Induces cell death and chromatin disruptions.

Sequence similarities: Belongs to the NUP210 family.

Sequence caution: The sequence BAB15332.1 differs from that shown. Reason: Erroneous initiation. The sequence BAC11688.1 differs from that shown. Reason: Erroneous initiation.