Rabbit Anti-GGCT Polyclonal Antibody – Cat# MBS645906

Western Blot analysis in 293 cell line lysates (35ug/lane) using MBS645906. GGCT (arrow) was detected using the purified Pab.

GGCT Antibody – Rabbit Polyclonal

Name: GGCT Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS645906
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS645906

GGCT (EC 2.3.2.4) catalyzes the formation of 5-oxoproline (pyroglutamic acid) from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. More details

$895 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GGCT, Polyclonal Antibody

Full Product Name

GGCT, CT (GGCT, C7orf24, CRF21, Gamma-glutamylcyclotransferase, Cytochrome c-releasing factor 21)

Product Gene Name

anti-GGCT antibody

Product Synonym Names

Anti -GGCT, CT (GGCT, C7orf24, CRF21, Gamma-glutamylcyclotransferase, Cytochrome c-releasing factor 21)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Human

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

21,008 Da

Chromosome Location

Chromosome: 7; NC_000007.13 (30536237..30544457, complement). Location: 7p15-p14

OMIM

137170

3D Structure

ModBase 3D Structure for O75223

Immunogen

GGCT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 146~176 amino acids from the C-terminal region of human GGCT.

Product Categories/Family for anti-GGCT antibody

Antibodies; Abs to Enzymes; Cytochrome

Applications Tested/Suitable for anti-GGCT antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-GGCT antibody

Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Other Notes

Small volumes of anti-GGCT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GGCT purchase

MBS645906 is an antibody targeting GGCT. Also known as GGCT, CT (GGCT, C7orf24, CRF21, Gamma-glutamylcyclotransferase, Cytochrome c-releasing factor 21). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GGCT. It may not necessarily be applicable to this product.

NCBI GI #

315360622

NCBI GeneID

79017

NCBI Accession #

NP_001186746.1

UniProt Primary Accession #

O75223

UniProt Secondary Accession #

Q9BS37; B2RDN0; B8ZZN4; B8ZZR8

UniProt Related Accession #

O75223

GenBank Nucleotide #

NM_001199817.1

NCBI Official Full Name

gamma-glutamylcyclotransferase isoform 4

NCBI Official Synonym Full Names

gamma-glutamylcyclotransferase

NCBI Official Symbol

GGCT

NCBI Official Synonym Symbols

GGC; GCTG; CRF21; C7orf24

UniProt Protein Name

Gamma-glutamylcyclotransferase

UniProt Synonym Protein Names

Cytochrome c-releasing factor 21

Protein Family

Gamma-glutamylcyclotransferase

UniProt Gene Name

GGCT

UniProt Synonym Gene Names

C7orf24; CRF21

UniProt Entry Name

GGCT_HUMAN

NCBI Protein Information

gamma-glutamylcyclotransferase; cytochrome c-releasing factor 21; gamma -glutamyl cyclotransferase

NCBI Summary for GGCT

The protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

UniProt Comments for GGCT

Function: Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis. Ref.5 Ref.7

Catalytic activity: (Gamma-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid.

Subunit structure: Homodimer

Probable. Ref.7 Ref.8

Induction: By geranylgeraniol. Ref.5

Sequence similarities: Belongs to the gamma-glutamylcyclotransferase family.

Biophysicochemical propertiesKinetic parameters:KM=2.0 mM for gamma-glutamyl-L-alanineVmax=50.3 µmol/min/mg enzyme

Research Articles on GGCT

1. C7orf24 has been recognized as a potent marker for bladder and breast cancers. Studies on the role of gamma-glutamylcyclotransferace may aid in the control of malignant transformation of these cancers.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-GGCT antibody

Products by Pathway	Pathway Diagram
Biological Oxidations Pathway antibodies	Biological Oxidations Pathway Diagram
Glutathione Conjugation Pathway antibodies	Glutathione Conjugation Pathway Diagram
Glutathione Metabolism Pathway antibodies	Glutathione Metabolism Pathway Diagram
Glutathione Metabolism Pathway antibodies	Glutathione Metabolism Pathway Diagram
Glutathione Synthesis And Recycling Pathway antibodies	Glutathione Synthesis And Recycling Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Phase II Conjugation Pathway antibodies	Phase II Conjugation Pathway Diagram

Diseases associated with anti-GGCT antibody

Disease Name	Pubmed Publications
Carcinoma Antibodies	>3 publications with GGCT and Carcinoma
Neoplasms, Experimental Antibodies	>1 publications with GGCT and Neoplasms, Experimental
Necrosis Antibodies	>1 publications with GGCT and Necrosis

Organs/Tissues associated with anti-GGCT antibody

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>4 publications with GGCT and Lung
Brain Antibodies	>3 publications with GGCT and Brain
Muscle Antibodies	>3 publications with GGCT and Muscle
Placenta Antibodies	>2 publications with GGCT and Placenta
Blood Antibodies	>1 publications with GGCT and Blood
Stomach Antibodies	>1 publications with GGCT and Stomach