Rabbit Anti-NSMCE4A Polyclonal Antibody – Cat# MBS645964

Western blot analysis of NSE4A Antibody (N-term) in WiDr cell line lysates (35ug/lane). NSE4A (arrow) was detected using the purified Pab.

NSMCE4A Antibody – Rabbit Polyclonal

Name: NSMCE4A Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS645964
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS645964

MBS645964 is an antibody targeting NSMCE4A. Also known as NSE4A, NT (NSMCE4A, C10orf86, Non-structural maintenance of chromosomes element 4 homolog A). Reactive in Human. Host: Rabbit. More details

$895 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

NSE4A (NSMCE4A), Polyclonal Antibody

Full Product Name

NSE4A, NT (NSMCE4A, C10orf86, Non-structural maintenance of chromosomes element 4 homolog A)

Product Gene Name

anti-NSMCE4A antibody

Product Synonym Names

Anti -NSE4A, NT (NSMCE4A, C10orf86, Non-structural maintenance of chromosomes element 4 homolog A)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Human

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

44,301 Da

Chromosome Location

Chromosome: 10; NC_000010.10 (123716603..123734743, complement). Location: 10q26.13

OMIM

612987

3D Structure

ModBase 3D Structure for Q9NXX6

Immunogen

NSE4A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 36~65 amino acids from the N-terminal region of human NSE4A.

Product Categories/Family for anti-NSMCE4A antibody

Antibodies; Abs to KIAA; orf

Applications Tested/Suitable for anti-NSMCE4A antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-NSMCE4A antibody

Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Other Notes

Small volumes of anti-NSMCE4A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for NSMCE4A. It may not necessarily be applicable to this product.

NCBI GI #

269846910

NCBI GeneID

54780

NCBI Accession #

NP_001161337.1

UniProt Primary Accession #

Q9NXX6

UniProt Secondary Accession #

Q5SQQ5; Q6P673; Q8WY66; Q9BS90

UniProt Related Accession #

Q9NXX6

GenBank Nucleotide #

NM_001167865.1

NCBI Official Full Name

non-structural maintenance of chromosomes element 4 homolog A isoform 2

NCBI Official Synonym Full Names

non-SMC element 4 homolog A (S. cerevisiae)

NCBI Official Symbol

NSMCE4A

NCBI Official Synonym Symbols

NS4EA; NSE4A; C10orf86

UniProt Protein Name

Non-structural maintenance of chromosomes element 4 homolog A

UniProt Gene Name

NSMCE4A

UniProt Synonym Gene Names

C10orf86; NS4EA

UniProt Entry Name

NSE4A_HUMAN

NCBI Protein Information

non-structural maintenance of chromosomes element 4 homolog A

UniProt Comments for NSMCE4A

Function: Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Is involved in positive regulation of response to DNA damage stimulus. Ref.7

Subunit structure: Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NDNL2. NSMCE1, NSMCE4A or EID3 and NDNL2 probably form a subcomplex that bridges the head domains of the SMC5:SMC6 heterodimer. Ref.7

Subcellular location: Nucleus. Chromosome › telomere

Probable Ref.7.

Sequence similarities: Belongs to the NSE4 family.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.