Rabbit Anti-HLA-DMB Polyclonal Antibody – Cat# MBS646003

HLA-DMB Antibody (Center) western blot analysis in Ramos cell line lysates (35ug/lane).This demonstrates the HLA-DMB antibody detected the HLA-DMB protein (arrow).

HLA-DMB Antibody – Rabbit Polyclonal

Name: HLA-DMB Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS646003
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS646003

HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the… More details

$895 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

HLA-DMB, Polyclonal Antibody

Full Product Name

HLA-DMB, ID (HLA-DMB, DMB, RING7, HLA class II histocompatibility antigen, DM beta chain, MHC class II antigen DMB, Really interesting new gene 7 protein)

Product Gene Name

anti-HLA-DMB antibody

Product Synonym Names

Anti -HLA-DMB, ID (HLA-DMB, DMB, RING7, HLA class II histocompatibility antigen, DM beta chain, MHC class II antigen DMB, Really interesting new gene 7 protein)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Human

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

28,943 Da

Chromosome Location

Chromosome: 6; NC_000006.11 (32902406..32908847, complement). Location: 6p21.3

OMIM

142856

3D Structure

ModBase 3D Structure for P28068

Immunogen

HLA-DMB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 103-133 amino acids from the Central region of human HLA-DMB.

Product Categories/Family for anti-HLA-DMB antibody

Antibodies; Abs to HLA

Applications Tested/Suitable for anti-HLA-DMB antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-HLA-DMB antibody

Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Other Notes

Small volumes of anti-HLA-DMB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HLA-DMB purchase

MBS646003 is an antibody targeting HLA-DMB. Also known as HLA-DMB, ID (HLA-DMB, DMB, RING7, HLA class II histocompatibility antigen, DM beta chain, MHC class II antigen DMB, Really interesting new gene 7 protein). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for HLA-DMB. It may not necessarily be applicable to this product.

NCBI GI #

301129275

NCBI GeneID

3109

NCBI Accession #

NP_002109.2

UniProt Primary Accession #

P28068

UniProt Secondary Accession #

O77936; Q13012; Q29751; Q58ZE2; Q5SNZ8; Q5STC4; Q9XRX2

UniProt Related Accession #

P28068

GenBank Nucleotide #

NM_002118.4

NCBI Official Full Name

HLA class II histocompatibility antigen, DM beta chain

NCBI Official Synonym Full Names

major histocompatibility complex, class II, DM beta

NCBI Official Symbol

HLA-DMB

NCBI Official Synonym Symbols

RING7; D6S221E

UniProt Protein Name

HLA class II histocompatibility antigen, DM beta chain

UniProt Synonym Protein Names

MHC class II antigen DMB; Really interesting new gene 7 protein

Protein Family

HLA class II histocompatibility antigen

UniProt Gene Name

HLA-DMB

UniProt Synonym Gene Names

DMB; RING7

UniProt Entry Name

DMB_HUMAN

NCBI Protein Information

HLA class II histocompatibility antigen, DM beta chain; MHC class II HLA-DMB; MHC class II antigen DMB; really interesting new gene 7 protein; MHC class II antigen HLA-DM beta chain; class II histocompatibility antigen, M beta chain

UniProt Comments for HLA-DMB

Function: Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Ref.12 Ref.15 Ref.16

Subunit structure: Heterodimer of an alpha chain (DMA) and a beta chain (DMB). Ref.15 Ref.16

Subcellular location: Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note: Localizes to late endocytic compartment. Associates with lysosome membranes. Ref.13

Domain: The YXXZ (Tyr-Xaa-Xaa-Zaa, where Zaa is a hydrophobic residue) motif mediates the targeting to the lysosomal compartments.

Polymorphism: The following alleles of DMB are known: DMB*01:01, DMB*01:02, DMB*01:03, DMB*01:04 (DMB3.4), DMB*01:05, DMB*01:06, and DMB*01:07. The sequence shown is that of DMB*01:01.

Sequence similarities: Belongs to the MHC class II family.Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Research Articles on HLA-DMB

1. The structure of the HLA-DM-HLA-DR complex shows major rearrangements of the HLA-DR peptide-binding groove.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-HLA-DMB antibody

Reference Product	PubMed Publications
HLA-DMA antibody	>328 publications with HLA-DMB and HLA-DMA
HLA-DRA antibody	>12 publications with HLA-DMB and HLA-DRA
CD74 antibody	>3 publications with HLA-DMB and CD74
HLA-DOA antibody	>2 publications with HLA-DMB and HLA-DOA
HLA-DPB1 antibody	>2 publications with HLA-DMB and HLA-DPB1
HLA-DRB5 antibody	>1 publications with HLA-DMB and HLA-DRB5

Pathways associated with anti-HLA-DMB antibody

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Diseases associated with anti-HLA-DMB antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>19 publications with HLA-DMB and Neoplasms
Nervous System Diseases Antibodies	>7 publications with HLA-DMB and Nervous System Diseases
Inflammation Antibodies	>5 publications with HLA-DMB and Inflammation
Dermatitis Antibodies	>3 publications with HLA-DMB and Dermatitis
Chromosome Aberrations Antibodies	>2 publications with HLA-DMB and Chromosome Aberrations
Liver Diseases Antibodies	>2 publications with HLA-DMB and Liver Diseases
Occupational Diseases Antibodies	>2 publications with HLA-DMB and Occupational Diseases
Necrosis Antibodies	>2 publications with HLA-DMB and Necrosis
Glioblastoma Antibodies	>1 publications with HLA-DMB and Glioblastoma
Carcinoma, Hepatocellular Antibodies	>1 publications with HLA-DMB and Carcinoma, Hepatocellular

Organs/Tissues associated with anti-HLA-DMB antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>125 publications with HLA-DMB and Blood
Kidney Antibodies	>9 publications with HLA-DMB and Kidney
Bone Antibodies	>9 publications with HLA-DMB and Bone
Bone Marrow Antibodies	>8 publications with HLA-DMB and Bone Marrow
Thymus Antibodies	>7 publications with HLA-DMB and Thymus
Lymph Node Antibodies	>6 publications with HLA-DMB and Lymph Node
Spleen Antibodies	>5 publications with HLA-DMB and Spleen
Skin Antibodies	>4 publications with HLA-DMB and Skin
Thyroid Antibodies	>3 publications with HLA-DMB and Thyroid
Brain Antibodies	>3 publications with HLA-DMB and Brain