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CHN1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS646015

This gene encodes GTPase-activating protein for p21-rac and a phorbol ester receptor. It plays an important role in ocular motor axon pathfinding. Heterozygous missense mutations in this gene cause Duane's retraction syndrome 2 (DURS2). Multiple transcript… More details

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Product Overview

Online Datasheet in PDF
Product Name
CHN1, Polyclonal Antibody
Full Product Name
CHN1, NT (CHN1, ARHGAP2, CHN, N-chimaerin, A-chimaerin, Alpha-chimerin, N-chimerin, Rho GTPase-activating protein 2)
Product Gene Name
anti-CHN1 antibody
Product Synonym Names
Anti -CHN1, NT (CHN1, ARHGAP2, CHN, N-chimaerin, A-chimaerin, Alpha-chimerin, N-chimerin, Rho GTPase-activating protein 2)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
34,335 Da
Chromosome Location
Chromosome: 2; NC_000002.11 (175664042..175870671, complement). Location: 2q31.1
3D Structure
ModBase 3D Structure for Q6IBE0
Immunogen
CHN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CHN1.

Product Categories/Family for anti-CHN1 antibody

Antibodies; Abs to GTPase; Rab; Ras; Rho Proteins
Applications Tested/Suitable for anti-CHN1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-CHN1 antibody
Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Western Blot (WB) of anti-CHN1 antibody

CHN1 Antibody (N-term) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the CHN1 antibody detected the CHN1 protein (arrow).
Rabbit Anti-CHN1 Polyclonal Antibody – Cat# MBS646015

Other Notes

Small volumes of anti-CHN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CHN1 purchase

MBS646015 is an antibody targeting CHN1. Also known as CHN1, NT (CHN1, ARHGAP2, CHN, N-chimaerin, A-chimaerin, Alpha-chimerin, N-chimerin, Rho GTPase-activating protein 2). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CHN1. It may not necessarily be applicable to this product.

NCBI GI #
48145845
NCBI GeneID
1123
NCBI Accession #
CAG33145.1
UniProt Primary Accession #
Q6IBE0
UniProt Related Accession #
P15882
NCBI Official Full Name
CHN1
NCBI Official Synonym Full Names
chimerin 1
NCBI Official Symbol
CHN1
NCBI Official Synonym Symbols
NC; CHN; DURS2; ARHGAP2; RHOGAP2
UniProt Protein Name
CHN1 protein
Protein Family
N-chimaerin
UniProt Gene Name
CHN1
UniProt Entry Name
Q6IBE0_HUMAN
NCBI Protein Information
N-chimaerin; n-chimerin; A-chimaerin; chimaerin 1; a2-chimaerin; alpha-chimerin; chimerin (chimaerin) 1; Rho GTPase-activating protein 2

NCBI Summary for CHN1

This gene encodes GTPase-activating protein for ras-related p21-rac and a phorbol ester receptor. It is predominantly expressed in neurons, and plays an important role in neuronal signal-transduction mechanisms. Mutations in this gene are associated with Duane's retraction syndrome 2 (DURS2). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]
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UniProt Comments for CHN1

ARHGAP2: GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance. Interacts with EPHA4; effector of EPHA4 in axon guidance linking EPHA4 activation to RAC1 regulation. In neurons in brain regions that are involved in learning and memory processes. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; GAPs; GAPs, Rac/Rho

Chromosomal Location of Human Ortholog: 2q31.1

Cellular Component: cytosol

Molecular Function: SH3/SH2 adaptor activity; ephrin receptor binding; metal ion binding; GTPase activator activity

Biological Process: regulation of small GTPase mediated signal transduction; positive regulation of signal transduction; small GTPase mediated signal transduction; ephrin receptor signaling pathway; motor axon guidance; regulation of axonogenesis; positive regulation of GTPase activity

Disease: Duane Retraction Syndrome 2
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Research Articles on CHN1

1. Cathepsin L- and K-cleaved chemerin trigger robust migration of human blood-derived plasmacytoid dendritic cells ex vivo

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CHN1 antibody

 Products by Pathway  Pathway Diagram
 Regulation Of RAC1 Activity Pathway antibodies  Regulation Of RAC1 Activity Pathway Diagram
 Rho GTPase Cycle Pathway antibodies  Rho GTPase Cycle Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Rho GTPases Pathway antibodies  Signaling By Rho GTPases Pathway Diagram

Organs/Tissues associated with anti-CHN1 antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >30 publications with CHN1 and Nerve
 Brain Antibodies  >30 publications with CHN1 and Brain
 Eye Antibodies  >8 publications with CHN1 and Eye
 Muscle Antibodies  >7 publications with CHN1 and Muscle
 Blood Antibodies  >4 publications with CHN1 and Blood
 Embryonic Tissue Antibodies  >2 publications with CHN1 and Embryonic Tissue
 Kidney Antibodies  >2 publications with CHN1 and Kidney
 Liver Antibodies  >2 publications with CHN1 and Liver
 Intestine Antibodies  >1 publications with CHN1 and Intestine
 Heart Antibodies  >1 publications with CHN1 and Heart
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