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Renalase (RNLS) Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS646055

MBS646055 is an antibody targeting RNLS. Also known as Renalase (FAD-dependent amine oxidase, RNLS, Hypothetical protein LOC55328, FLJ11218, HGNC:25641, Chromosome 10 open reading frame 59, C10orf59). Reactive in Human, Mouse. Host: Goat. More details

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Product Overview

Online Datasheet in PDF
Product Name
Renalase (RNLS), Polyclonal Antibody
Full Product Name
Renalase (FAD-dependent amine oxidase, RNLS, Hypothetical protein LOC55328, FLJ11218, HGNC:25641, Chromosome 10 open reading frame 59, C10orf59)
Product Gene Name
anti-RNLS antibody
Product Synonym Names
Anti -Renalase (FAD-dependent amine oxidase, RNLS, Hypothetical protein LOC55328, FLJ11218, HGNC:25641, Chromosome 10 open reading frame 59, C10orf59)
Clonality
Polyclonal
Host
Goat
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human Renalase. Species Crossreactivity
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
37,847 Da
Chromosome Location
Chromosome: 10; NC_000010.10 (90033621..90343611, complement). Location: 10q23.31
OMIM
609360
3D Structure
ModBase 3D Structure for Q5VYX0
Immunogen
Synthetic peptide corresponding to C-VSIDNKKRNI, aa224-233 of human Renalase.

Product Categories/Family for anti-RNLS antibody

Antibodies; Abs to Enzymes; Oxidase
Applications Tested/Suitable for anti-RNLS antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-RNLS antibody
Suitable for use in ELISA, Immunohistochemistry and Western Blot.
Dilution: ELISA: 1:64000
Western Blot: 0.1-0.3ug/ml
Immunohistochemistry: 3ug/ml

Chemiluminescence of anti-RNLS antibody

R1450-40C (0.5ug/ml) staining of Mouse Heart (A) and Rat Heart (B) lysates (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-RNLS Polyclonal Antibody – Cat# MBS646055

Immunohistochemistry (IHC) of anti-RNLS antibody

R1450-40C (2ug/ml) staining of paraffin embedded Human Kidney. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining.
Goat Anti-RNLS Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS646055

Other Notes

Small volumes of anti-RNLS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for RNLS. It may not necessarily be applicable to this product.

NCBI GI #
237649117
NCBI GeneID
55328
NCBI Accession #
NP_001026879.2
UniProt Primary Accession #
Q5VYX0
UniProt Secondary Accession #
Q9BS33; Q9NUP8
UniProt Related Accession #
Q5VYX0
GenBank Nucleotide #
NM_001031709.2
NCBI Official Full Name
renalase isoform 1
NCBI Official Synonym Full Names
renalase, FAD-dependent amine oxidase
NCBI Official Symbol
RNLS
NCBI Official Synonym Symbols
C10orf59; RENALASE
UniProt Protein Name
Renalase
UniProt Synonym Protein Names
Monoamine oxidase-C
Protein Family
Renalase
UniProt Gene Name
RNLS
UniProt Synonym Gene Names
C10orf59; MAO-C
UniProt Entry Name
RNLS_HUMAN
NCBI Protein Information
renalase; MAO-C; monoamine oxidase-C

NCBI Summary for RNLS

Renalase is a flavin adenine dinucleotide-dependent amine oxidase that is secreted into the blood from the kidney (Xu et al., 2005 [PubMed 15841207]).[supplied by OMIM, Mar 2008]

UniProt Comments for RNLS

Function: Probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. Degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis

By similarity. According to Ref.5, is unlikely that renalase has physiologically relevant catecholamine-oxidizing activity. Ref.4 Ref.5

Cofactor: FAD. Ref.6

Subcellular location: Secreted Ref.4.

Tissue specificity: Secreted into the blood by the kidney. Highly expressed in the kidney, expressed at lower level in heart, skeletal muscle and small intestine. Its plasma concentration is markedly reduced in patients with end-stage renal disease, as compared with healthy subjects. Ref.4

Sequence similarities: Belongs to the renalase family.
Show more

Research Articles on RNLS

1. Renalase is elevated among heart transplant recipients and is predominantly dependent on renal function

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-RNLS antibody

 Products by Pathway  Pathway Diagram
 Noradrenaline And Adrenaline Degradation Pathway antibodies  Noradrenaline And Adrenaline Degradation Pathway Diagram

Diseases associated with anti-RNLS antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >3 publications with RNLS and Neoplasms
 Neoplasm Metastasis Antibodies  >2 publications with RNLS and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >2 publications with RNLS and Breast Neoplasms
 Inflammation Antibodies  >2 publications with RNLS and Inflammation
 Hypertension Antibodies  >1 publications with RNLS and Hypertension
 Cardiovascular Diseases Antibodies  >1 publications with RNLS and Cardiovascular Diseases

Organs/Tissues associated with anti-RNLS antibody

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >1 publications with RNLS and Eye
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