Rabbit Anti-CCL3 Polyclonal Antibody – Cat# MBS6460706

Anti-CCL3 antibody, All lanes: Anti-CCL3 at 0.5ug/ml WB: Recombinant Rat CCL3 Protein 0.5ng Predicted band size: 33KD Observed band size: 33KD

CCL3 Antibody – Rabbit Polyclonal

Name: CCL3 Antibody; Polyclonal; Rabbit; Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6460706
Price: 1065 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6460706

MBS6460706 is an antibody targeting CCL3. Also known as CCL3 (C C Motif Chemokine 3, CCL 3, CCL3_HUMAN, Chemokine C C Motif Ligand 3, Chemokine CC Motif Ligand 3, G0/G1 Switch Regulatory Protein 19 1, G0/G1 Switch Regulatory Protein 19-1, G0S19 1, G0S19 1… More details

$1065 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CCL3, Polyclonal Antibody

Full Product Name

CCL3 (C C Motif Chemokine 3, CCL 3, CCL3_HUMAN, Chemokine C C Motif Ligand 3, Chemokine CC Motif Ligand 3, G0/G1 Switch Regulatory Protein 19 1, G0/G1 Switch Regulatory Protein 19-1, G0S19 1, G0S19 1 Protein, Heparin Binding Chemotaxis Protein, L2G25B, LD

Product Gene Name

anti-CCL3 antibody

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Rat

Form/Format

Supplied as a liquid in PBS, pH 7.2. Labeled with Allophycocyanin (APC).

Purity/Purification

Purified by Immunoaffinity chromatography.

Specificity

Recognizes rat CCL3.

Preparation and Storage

Lyophilized powder may be stored at -20 degree C. Stable for 12 months after receipt at -20 degree C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

10,335 Da

3D Structure

ModBase 3D Structure for P50229

Immunogen

Recombinant protein corresponding to rat CCL3 expressed in E. coli. (Position: A24-A92). Species sequence homology: human (74%) and mouse (91%)

Conjugate

APC

Note

Preservative Free

Product Categories/Family for anti-CCL3 antibody

Antibodies; Growth Factors; Cytokines

Applications Tested/Suitable for anti-CCL3 antibody

Western Blot (WB), ELISA (EIA)

Application Notes for anti-CCL3 antibody

WB: 0.1-0.5ug/ml, the detection limit is ~1ng/lane under reducing conditions.
ELISA: 0.1-0.5ug/ml
Applications are based on unconjugated antibody.

Product References and Citations for anti-CCL3 antibody

1. Wolpe, S. D.; Cerami, A. Macrophage inflammatory proteins 1 and 2: members of a novel superfamily of cytokines. FASEB J. 3: 2565-2573, 1989. 2. Nakao, M.; Nomiyama, H.; Shimada, K. Structures of human genes coding for cytokine LD78 and their expression. Molec. Cell. Biol. 10: 3646-3658, 1990. 3. Cook, D. N.; Beck, M. A.; Coffman, T. M.; Kirby, S. L.; Sheridan, J. F.; Pragnell, I. B.; Smithies, O. Requirement of MIP-1-alpha for an inflammatory response to viral infection. Science 269: 1583-1585, 1995. 4. Miyazaki, D.; Nakamura, T.; Toda, M.; Cheung-Chau, K.-W.; Richardson, R. M.; Ono, S. J. Macrophage inflammatory protein-1-alpha as a costimulatory signal for mast cell-mediated immediate hypersensitivity reactions. J. Clin. Invest. 115: 434-442, 2005.

Other Notes

Small volumes of anti-CCL3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CCL3. It may not necessarily be applicable to this product.

NCBI GI #

40254794

NCBI GeneID

25542

NCBI Accession #

NP_037157.2

UniProt Primary Accession #

P50229

UniProt Secondary Accession #

A1EC87

UniProt Related Accession #

P50229

GenBank Nucleotide #

NM_013025.2

NCBI Official Full Name

C-C motif chemokine 3

NCBI Official Synonym Full Names

chemokine (C-C motif) ligand 3

NCBI Official Symbol

Ccl3

NCBI Official Synonym Symbols

Scya3; MIP-1a

UniProt Protein Name

C-C motif chemokine 3

UniProt Synonym Protein Names

Macrophage inflammatory protein 1-alpha; MIP-1-alpha; Small-inducible cytokine A3

Protein Family

C-C motif chemokine

UniProt Gene Name

Ccl3

UniProt Synonym Gene Names

Mip1a; Scya3; MIP-1-alpha

UniProt Entry Name

CCL3_RAT

NCBI Protein Information

C-C motif chemokine 3; MIP-1-alpha; Macrophage inflammatory protein 1 alpha (Small inducible cytokine A3); macrophage inflammatory protein 1-alpha; small inducible cytokine A3; small-inducible cytokine A3

NCBI Summary for CCL3

mediates monocyte and neutrophil chemotaxis; may play a role in the pathogenesis of acute lung injury [RGD, Feb 2006]

UniProt Comments for CCL3

Monokine with inflammatory and chemokinetic properties. Has chemotactic activity for monocytes, neutrophils, eosinophils, basophils, and lymphocytes. Required for lung TNF-alpha production, neutrophil recruitment and subsequent lung injury and may function as an autocrine mediator for the macrophage production of TNF-alpha which in turn up-regulates vascular adhesion molecules required for neutrophil influx. This protein binds heparin.

Research Articles on CCL3

1. Expression levels of CCL3 in the spinal cord are up-regulated following nerve injury.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CCL3 antibody

Products by Pathway	Pathway Diagram
Chagas Disease (American Trypanosomiasis) Pathway antibodies	Chagas Disease (American Trypanosomiasis) Pathway Diagram
Chagas Disease (American Trypanosomiasis) Pathway antibodies	Chagas Disease (American Trypanosomiasis) Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies	Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram

Diseases associated with anti-CCL3 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>893 publications with CCL3 and Inflammation
Necrosis Antibodies	>506 publications with CCL3 and Necrosis
Disease Models, Animal Antibodies	>314 publications with CCL3 and Disease Models, Animal
Lung Diseases Antibodies	>238 publications with CCL3 and Lung Diseases
HIV Infections Antibodies	>188 publications with CCL3 and HIV Infections
Cardiovascular Diseases Antibodies	>173 publications with CCL3 and Cardiovascular Diseases
Hypersensitivity Antibodies	>105 publications with CCL3 and Hypersensitivity
Liver Diseases Antibodies	>95 publications with CCL3 and Liver Diseases
Fibrosis Antibodies	>79 publications with CCL3 and Fibrosis
Pneumonia Antibodies	>72 publications with CCL3 and Pneumonia

Organs/Tissues associated with anti-CCL3 antibody

Organ/Tissue Name	Pubmed Publications
Connective Tissue Antibodies	>41 publications with CCL3 and Connective Tissue
Adipose Tissue Antibodies	>22 publications with CCL3 and Adipose Tissue
Inner Ear Antibodies	>1 publications with CCL3 and Inner Ear