Rabbit Anti-VGLL2 Polyclonal Antibody – Cat# MBS646084

VGLL2 Antibody (N-term) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the VGLL2 antibody detected the VGLL2 protein (arrow).

VGLL2 Antibody – Rabbit Polyclonal

Name: VGLL2 Antibody; Polyclonal; Rabbit; Human/Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS646084
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS646084

May act as a specific coactivator for the mammalian TEFs. May play a role in the development of skeletal muscles. More details

$895 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

VGLL2, Polyclonal Antibody

Full Product Name

VGLL2, NT (VGLL2, VITO1, Transcription cofactor vestigial-like protein 2, Protein VITO1)

Product Gene Name

anti-Vgll2 antibody

Product Synonym Names

Anti -VGLL2, NT (VGLL2, VITO1, Transcription cofactor vestigial-like protein 2, Protein VITO1)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse

Form/Format

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Human, mouse

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

34,064 Da

Chromosome Location

Chromosome: 10; NC_000076.6 (52022686..52028471). Location: 10 B3; 10

3D Structure

ModBase 3D Structure for Q8BGW8

Immunogen

VGLL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 52-81 amino acids from the N-terminal region of human VGLL2.

Product Categories/Family for anti-Vgll2 antibody

Antibodies; Abs to Transcription Factors

Applications Tested/Suitable for anti-Vgll2 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-Vgll2 antibody

Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Other Notes

Small volumes of anti-Vgll2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Vgll2 purchase

MBS646084 is an antibody targeting Vgll2. Also known as VGLL2, NT (VGLL2, VITO1, Transcription cofactor vestigial-like protein 2, Protein VITO1). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Vgll2. It may not necessarily be applicable to this product.

NCBI GI #

126632179

NCBI GeneID

215031

NCBI Accession #

AAI33697.1

UniProt Primary Accession #

Q8BGW8

UniProt Secondary Accession #

Q8BWB4

UniProt Related Accession #

Q8BGW8

NCBI Official Full Name

Vgll2 protein

NCBI Official Synonym Full Names

vestigial like 2 homolog (Drosophila)

NCBI Official Symbol

Vgll2

NCBI Official Synonym Symbols

Vito1; VITO-1; C130057C21Rik

UniProt Protein Name

Transcription cofactor vestigial-like protein 2

UniProt Synonym Protein Names

Protein VITO1

Protein Family

Transcription cofactor vestigial-like protein

UniProt Gene Name

Vgll2

UniProt Synonym Gene Names

Vgl2; Vito1; Vgl-2

UniProt Entry Name

VGLL2_MOUSE

NCBI Protein Information

transcription cofactor vestigial-like protein 2; vgl-2

NCBI Summary for Vgll2

This gene is a member of the Vestigial-like (Vgl) gene family and is upregulated during muscle differentiation. The product of this gene interacts with and modifies the DNA-binding properties of the transcription factor, TEF-1, and is important for muscle tissue development. Reduced expression of this gene leads to a reduction in the terminal differentiation of muscle cells. Alternate splicing results in multiple protein isoforms. [provided by RefSeq, Jul 2014]

UniProt Comments for Vgll2

Function: May act as a specific coactivator for the mammalian TEFs. May play a role in the development of skeletal muscles. Ref.1

Subunit structure: Interacts with TEFs. Binds to TEAD1/TEF1. Ref.1

Subcellular location: Nucleus Ref.1.

Tissue specificity: Skeletal muscle specific. Ref.2

Developmental stage: Expressed in the somitic myotome from E8.75 mouse embryos onwards and later on in skeletal muscle but not in the heart. Additional expression domains during development are detected in the pharyngeal pouches and clefts starting at E8.0 as well as in the cranial pharynx and in Rathkes pouch. Ref.2

Sequence similarities: Belongs to the vestigial family.

Research Articles on Vgll2

1. VITO-1 is a crucial new cofactor of the muscle regulatory programme; VITO-1, a new scalloped interaction domain-containing protein, binds to TEF1 in vitro and strongly stimulates transcription of a reporter plasmid together with TEF-1

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-Vgll2 antibody

Disease Name	Pubmed Publications
Congenital Abnormalities Antibodies	>1 publications with Vgll2 and Congenital Abnormalities
Inflammation Antibodies	>1 publications with Vgll2 and Inflammation

Organs/Tissues associated with anti-Vgll2 antibody

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>9 publications with Vgll2 and Muscle
Embryonic Tissue Antibodies	>3 publications with Vgll2 and Embryonic Tissue