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SNRPD3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS646089

The protein belongs to the small nuclear ribonucleoprotein core protein family. It is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
SNRPD3, Polyclonal Antibody
Full Product Name
SNRPD3, CT (SNRPD3, Small nuclear ribonucleoprotein Sm D3, snRNP core protein D3)
Product Gene Name
anti-SNRPD3 antibody
Product Synonym Names
Anti -SNRPD3, CT (SNRPD3, Small nuclear ribonucleoprotein Sm D3, snRNP core protein D3)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
13,916 Da
Chromosome Location
Chromosome: 22; NC_000022.10 (24951618..24970932). Location: 22q11.23
OMIM
601062
3D Structure
ModBase 3D Structure for P62318
Immunogen
SNRPD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 97~126 amino acids from the C-terminal region of human SNRPD3.

Product Categories/Family for anti-SNRPD3 antibody

Antibodies; Abs to Nuclear Proteins
Applications Tested/Suitable for anti-SNRPD3 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
Application Notes for anti-SNRPD3 antibody
Suitable for use in Western Blot, Immunohistochemistry, Flow Cytometry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:50-100
Flow Cytometry: 1:10-50

Western Blot (WB) of anti-SNRPD3 antibody

Western blot analysis of SNRPD3 Antibody (C-term) in MCF-7, Jurkat cell line lysates (35ug/lane). SNRPD3 (arrow) was detected using the purified Pab.
Rabbit Anti-SNRPD3 Polyclonal Antibody – Cat# MBS646089

Immunohistochemistry (IHC) of anti-SNRPD3 antibody

SNRPD3 Antibody (C-term) IHC analysis in formalin fixed and paraffin embedded human lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the SNRPD3 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-SNRPD3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS646089

Flow Cytometry (FC/FACS) of anti-SNRPD3 antibody

SNRPD3 Antibody (C-term) flow cytometric analysis of MCF-7 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-SNRPD3 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS646089

Other Notes

Small volumes of anti-SNRPD3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SNRPD3 purchase

MBS646089 is an antibody targeting SNRPD3. Also known as SNRPD3, CT (SNRPD3, Small nuclear ribonucleoprotein Sm D3, snRNP core protein D3). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SNRPD3. It may not necessarily be applicable to this product.

NCBI GI #
521258690
NCBI GeneID
6634
NCBI Accession #
NP_001265585.1
UniProt Primary Accession #
P62318
UniProt Secondary Accession #
P43331; B5BU13
UniProt Related Accession #
P62318
GenBank Nucleotide #
NM_001278656.1
NCBI Official Full Name
small nuclear ribonucleoprotein Sm D3
NCBI Official Synonym Full Names
small nuclear ribonucleoprotein D3 polypeptide 18kDa
NCBI Official Symbol
SNRPD3
NCBI Official Synonym Symbols
SMD3; Sm-D3
UniProt Protein Name
Small nuclear ribonucleoprotein Sm D3
UniProt Synonym Protein Names
snRNP core protein D3
UniProt Gene Name
SNRPD3
UniProt Synonym Gene Names
Sm-D3
UniProt Entry Name
SMD3_HUMAN
NCBI Protein Information
small nuclear ribonucleoprotein Sm D3; snRNP core protein D3

NCBI Summary for SNRPD3

This gene encodes a core component of the spliceosome, which is a nuclear ribonucleoprotein complex that functions in pre-mRNA splicing. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

UniProt Comments for SNRPD3

Function: Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner. Ref.7

Subunit structure: Component of the heptameric ring U7 snRNP complex, or U7 Sm protein core complex, at least composed of LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA. Formation of the U7 snRNP is an ATP-dependent process mediated by a specialized SMN complex containing at least the Sm protein core complex and additionally, the U7-specific LSM10 and LSM11 proteins. Identified in the spliceosome C complex. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Ref.7 Ref.8 Ref.9

Subcellular location: Nucleus.

Post-translational modification: Methylated on arginine residues by PRMT5 and PRMT7; methylation is required for assembly and biogenesis of snRNPs. Ref.6 Ref.10Arg-97 is dimethylated, probably to asymmetric dimethylarginine. Ref.6 Ref.10

Miscellaneous: In the autoimmune disease systemic lupus erythematosus, antinuclear antibodies are developed with Sm specificity.

Sequence similarities: Belongs to the snRNP core protein family.
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Research Articles on SNRPD3

1. The dimethylated arginine residues play an essential role in the formation of major SmD3 autoepitopes. 1 particular peptide of SmD3 represents a more sensitive and more reliable substrate for the detection of a subclass of anti-Sm antibodies.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SNRPD3 antibody

 Reference Product  PubMed Publications
 SNRPE antibody  >14 publications with SNRPD3 and SNRPE
 SNRPF antibody  >14 publications with SNRPD3 and SNRPF
 SNRPN antibody  >14 publications with SNRPD3 and SNRPN

Pathways associated with anti-SNRPD3 antibody

 Products by Pathway  Pathway Diagram
 Cleavage Of Growing Transcript In The Termination Region Pathway antibodies  Cleavage Of Growing Transcript In The Termination Region Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Metabolism Of Non-coding RNA Pathway antibodies  Metabolism Of Non-coding RNA Pathway Diagram
 Processing Of Capped Intron-Containing Pre-mRNA Pathway antibodies  Processing Of Capped Intron-Containing Pre-mRNA Pathway Diagram
 Processing Of Capped Intronless Pre-mRNA Pathway antibodies  Processing Of Capped Intronless Pre-mRNA Pathway Diagram
 RNA Polymerase II Transcription Pathway antibodies  RNA Polymerase II Transcription Pathway Diagram
 RNA Polymerase II Transcription Termination Pathway antibodies  RNA Polymerase II Transcription Termination Pathway Diagram
 SLBP Dependent Processing Of Replication-Dependent Histone Pre-mRNAs Pathway antibodies  SLBP Dependent Processing Of Replication-Dependent Histone Pre-mRNAs Pathway Diagram
 SLBP Independent Processing Of Histone Pre-mRNAs Pathway antibodies  SLBP Independent Processing Of Histone Pre-mRNAs Pathway Diagram
 Sm Core Complex Pathway antibodies  Sm Core Complex Pathway Diagram

Diseases associated with anti-SNRPD3 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >3 publications with SNRPD3 and Nervous System Diseases
 Neoplasms Antibodies  >3 publications with SNRPD3 and Neoplasms
 Breast Neoplasms Antibodies  >1 publications with SNRPD3 and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >1 publications with SNRPD3 and Neoplasm Metastasis

Organs/Tissues associated with anti-SNRPD3 antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >4 publications with SNRPD3 and Nerve
 Blood Antibodies  >4 publications with SNRPD3 and Blood
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