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CD3G Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS646092

CD3G is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CD3G, Polyclonal Antibody
Full Product Name
CD3G, NT (CD3G, T3G, T-cell surface glycoprotein CD3 gamma chain, T-cell receptor T3 gamma chain, CD3g)
Product Gene Name
anti-CD3G antibody
Product Synonym Names
Anti -CD3G, NT (CD3G, T3G, T-cell surface glycoprotein CD3 gamma chain, T-cell receptor T3 gamma chain, CD3g)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by peptide immunoaffinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
20,469 Da
Chromosome Location
Chromosome: 11; NC_000011.9 (118215032..118224497). Location: 11q23
OMIM
186740
3D Structure
ModBase 3D Structure for P09693
Immunogen
CD3G antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55~84 amino acids from the N-terminal region of human CD3G.

Product Categories/Family for anti-CD3G antibody

Antibodies; Abs to CD Markers
Applications Tested/Suitable for anti-CD3G antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
Application Notes for anti-CD3G antibody
Suitable for use in Western Blot, Immunohistochemistry, Flow Cytometry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:50-100
Immunohistochemistry: 1:10-50
Flow Cytometry: 1:10-50

Western Blot (WB) of anti-CD3G antibody

Western blot analysis of HL60 cell line lysates (35ug/lane) using MBS646092. CD3G (arrow) was detected using MBS646092.
Rabbit Anti-CD3G Polyclonal Antibody – Cat# MBS646092

Immunohistochemistry (IHC) of anti-CD3G antibody

Formalin-fixed and paraffin-embedded human brain tissue reacted with MBS646092, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry.
Rabbit Anti-CD3G Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS646092

Flow Cytometry (FC/FACS) of anti-CD3G antibody

Flow cytometric analysis of HL-60 cells using MBS646092 (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-CD3G Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS646092

Other Notes

Small volumes of anti-CD3G antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD3G purchase

MBS646092 is an antibody targeting CD3G. Also known as CD3G, NT (CD3G, T3G, T-cell surface glycoprotein CD3 gamma chain, T-cell receptor T3 gamma chain, CD3g). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CD3G. It may not necessarily be applicable to this product.

NCBI GI #
119587772
NCBI GeneID
917
NCBI Accession #
EAW67368.1
UniProt Primary Accession #
P09693
UniProt Secondary Accession #
Q2HIZ6
UniProt Related Accession #
P09693
NCBI Official Full Name
CD3g antigen, gamma polypeptide (TiT3 complex)
NCBI Official Synonym Full Names
CD3g molecule, gamma (CD3-TCR complex)
NCBI Official Symbol
CD3G
NCBI Official Synonym Symbols
T3G; CD3-GAMMA
UniProt Protein Name
T-cell surface glycoprotein CD3 gamma chain
UniProt Synonym Protein Names
T-cell receptor T3 gamma chain
Protein Family
T-cell surface glycoprotein
UniProt Gene Name
CD3G
UniProt Synonym Gene Names
T3G
UniProt Entry Name
CD3G_HUMAN
NCBI Protein Information
T-cell surface glycoprotein CD3 gamma chain; T-cell receptor T3 gamma chain; CD3g molecule, epsilon (CD3-TCR complex); CD3g antigen, gamma polypeptide (TiT3 complex); T-cell antigen receptor complex, gamma subunit of T3

NCBI Summary for CD3G

The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. [provided by RefSeq, Jul 2008]
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UniProt Comments for CD3G

Function: The CD3 complex mediates signal transduction.

Subunit structure: The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta. Ref.8

Subcellular location: Membrane; Single-pass type I membrane protein.

Domain: A di-leucine motif and a tyrosine-based motif are individually sufficient to induce both endocytosis and delivery to lysosomes.

Sequence similarities: Contains 1 Ig-like (immunoglobulin-like) domain.Contains 1 ITAM domain.
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Research Articles on CD3G

1. The surface TCR expression of primary alphabeta and gammadelta T cells from healthy donors carrying a single null or leaky mutation in CD3G (gamma+/-) or CD3D (delta+/-, delta+/leaky) with that of normal controls, were compared.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD3G antibody

 Reference Product  PubMed Publications
 CD3D antibody  >12 publications with CD3G and CD3D
 CD3E antibody  >6 publications with CD3G and CD3E
 CD8A antibody  >2 publications with CD3G and CD8A
 LCK antibody  >2 publications with CD3G and LCK
 TRAT1 antibody  >1 publications with CD3G and TRAT1
 LCP2 antibody  >1 publications with CD3G and LCP2
 ITK antibody  >1 publications with CD3G and ITK
 FYN antibody  >1 publications with CD3G and FYN
 CD247 antibody  >1 publications with CD3G and CD247

Pathways associated with anti-CD3G antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Costimulation By The CD28 Family Pathway antibodies  Costimulation By The CD28 Family Pathway Diagram
 Downstream TCR Signaling Pathway antibodies  Downstream TCR Signaling Pathway Diagram
 Downstream Signaling In Naive CD8+ T Cells Pathway antibodies  Downstream Signaling In Naive CD8+ T Cells Pathway Diagram
 FCGR Activation Pathway antibodies  FCGR Activation Pathway Diagram
 Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway antibodies  Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway Diagram
 Generation Of Second Messenger Molecules Pathway antibodies  Generation Of Second Messenger Molecules Pathway Diagram

Diseases associated with anti-CD3G antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >8 publications with CD3G and Neoplasms
 Lymphoma Antibodies  >5 publications with CD3G and Lymphoma
 Inflammation Antibodies  >1 publications with CD3G and Inflammation
 Liver Diseases Antibodies  >1 publications with CD3G and Liver Diseases
 Liver Neoplasms Antibodies  >1 publications with CD3G and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >1 publications with CD3G and Carcinoma, Hepatocellular

Organs/Tissues associated with anti-CD3G antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >12 publications with CD3G and Blood
 Thymus Antibodies  >2 publications with CD3G and Thymus
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